公开(公告)号：US07482358B2

公开(公告)日：2009-01-27

申请号：US11348459

申请日：2006-02-07

申请人： Nagaaki Sato ,  Osamu Okamoto ,  Makoto Jitsuoka ,  Keita Nagai ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Takehiro Fukami

发明人： Nagaaki Sato ,  Osamu Okamoto ,  Makoto Jitsuoka ,  Keita Nagai ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Takehiro Fukami

IPC分类号： A61K31/435 ,  C07D401/00

CPC分类号： C07D401/04 ,  C07D233/26 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

摘要： Compounds represented by the general formula (I): wherein Ar1 and Ar2 are each aryl or heteroaryl; R1 is lower cycloalkyl, —Ar3, or a group of the general formula (a), (b) or (c): and R2 and R3are each hydrogen, lower cycloalkyl, lower alkenyl, or optionally substituted lower alkyl (with the proviso that when R2 and R3 are simultaneously hydrogen, Ar1, Ar2 and R1 do not simultaneously represent unsubstituted phenyl). The compounds are useful as treating agents for various NPY-related diseases, for example, circulatory diseases including hypertension, kidney diseases, cardiac diseases, vasospasm and arteriosclerosis; central nervous system diseases including hyperphagia, depression, anxiety, convulsion, epilepsy, dementia, pain, alcohol dependence, and withdrawal symptoms due to abstinence from drugs; metabolic diseases including obesity, diabetes, hormonal disorders, hypercholesterolemia, and hyperlipidemia; sexual dysfunction and reproductive function disorders; digestive diseases including enterokinetic disorders; respiratory diseases; inflammation; or glaucoma.

摘要翻译： 由通式（I）表示的化合物：其中Ar1和Ar2各自为芳基或杂芳基; R 1是低级环烷基，-Ar 3或通式（a），（b）或（c）的基团：R 2和R 3各自为氢，低级环烷基，低级烯基或任选取代的低级烷基（条件是 当R2和R3同时为氢时，Ar1，Ar2和R1不同时表示未取代的苯基）。 这些化合物可用作各种NPY相关疾病的治疗剂，例如包括高血压，肾脏疾病，心脏病，血管痉挛和动脉硬化的循环系统疾病; 中枢神经系统疾病，包括食欲过多，抑郁，焦虑，惊厥，癫痫，痴呆，疼痛，酒精依赖以及戒毒症状; 代谢疾病包括肥胖，糖尿病，激素失调，高胆固醇血症和高脂血症; 性功能障碍和生殖功能障碍; 消化疾病包括肠动力障碍; 呼吸疾病; 炎; 或青光眼。

公开(公告)号：US20060135559A1

公开(公告)日：2006-06-22

申请号：US11348459

申请日：2006-02-07

申请人： Nagaaki Sato ,  Osamu Okamoto ,  Makoto Jitsuoka ,  Keita Nagai ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Takehiro Fukami

发明人： Nagaaki Sato ,  Osamu Okamoto ,  Makoto Jitsuoka ,  Keita Nagai ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Takehiro Fukami

IPC分类号： A61K31/4709 ,  A61K31/4439 ,  A61K31/4178 ,  C07D409/02 ,  C07D403/02

CPC分类号： C07D401/04 ,  C07D233/26 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

摘要： Compounds represented by the general formula (I): wherein Ar1 and Ar2 are each aryl or heteroaryl; R1 is lower cycloalkyl, —Ar3, or a group of the general formula (a), (b) or (c): and R2 and R3are each hydrogen, lower cycloalkyl, lower alkenyl, or optionally substituted lower alkyl (with the proviso that when R2 and R3 are simultaneously hydrogen, Ar1, Ar2 and R1 do not simultaneously represent unsubstituted phenyl). The compounds are useful as treating agents for various NPY-related diseases, for example, circulatory diseases including hypertension, kidney diseases, cardiac diseases, vasospasm and arteriosclerosis; central nervous system diseases including hyperphagia, depression, anxiety, convulsion, epilepsy, dementia, pain, alcohol dependence, and withdrawal symptoms due to abstinence from drugs; metabolic diseases including obesity, diabetes, hormonal disorders, hypercholesterolemia, and hyperlipidemia; sexual dysfunction and reproductive function disorders; digestive diseases including enterokinetic disorders; respiratory diseases; inflammation; or glaucoma.

摘要翻译： 由通式（I）表示的化合物：其中Ar 1和Ar 2各自为芳基或杂芳基; R 1是低级环烷基，-Ar 3或通式（a），（b）或（c）的基团：R 2， R 3和R 3各自为氢，低级环烷基，低级烯基或任选取代的低级烷基（条件是当R 2和R 3' / SUP>同时为氢，Ar 1，Ar 2和R 1不同时表示未取代的苯基）。 这些化合物可用作各种NPY相关疾病的治疗剂，例如包括高血压，肾脏疾病，心脏病，血管痉挛和动脉硬化的循环系统疾病; 中枢神经系统疾病，包括食欲过多，抑郁，焦虑，惊厥，癫痫，痴呆，疼痛，酒精依赖以及戒毒症状; 代谢疾病包括肥胖，糖尿病，激素失调，高胆固醇血症和高脂血症; 性功能障碍和生殖功能障碍; 消化疾病包括肠动力障碍; 呼吸疾病; 炎; 或青光眼。

公开(公告)号：US07064142B2

公开(公告)日：2006-06-20

申请号：US10204267

申请日：2001-02-22

申请人： Nagaaki Sato ,  Osamu Okamoto ,  Makoto Jitsuoka ,  Keita Nagai ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Takehiro Fukami

发明人： Nagaaki Sato ,  Osamu Okamoto ,  Makoto Jitsuoka ,  Keita Nagai ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Takehiro Fukami

IPC分类号： A61K31/415 ,  C07D233/26

CPC分类号： C07D401/04 ,  C07D233/26 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

摘要： Compounds represented by the general formula (I): wherein Ar1 and Ar2 are each aryl or heteroaryl; R1 is lower cycloalkyl, —Ar3, or a group of the general formula (a), (b) or (c): and R2 and R3 are each hydrogen, lower cycloalkyl, lower alkenyl, or optionally substituted lower alkyl (with the proviso that when R2 and R3 are simultaneously hydrogen, Ar1, Ar2 and R1 do not simultaneously represent unsubstituted phenyl). The compounds are useful as treating agents for various NPY-related diseases, for example, circulatory diseases including hypertension, kidney diseases, cardiac diseases, vasospasm and arteriosclerosis; central nervous system diseases including hyperphagia, depression, anxiety, convulsion, epilepsy, dementia, pain, alcohol dependence, and withdrawal symptoms due to abstinence from drugs; metabolic diseases including obesity, diabetes, hormonal disorders, hypercholesterolemia, and hyperlipidemia; sexual dysfunction and reproductive function disorders; digestive diseases including enterokinetic disorders; respiratory diseases; inflammation; or glaucoma.

摘要翻译： 由通式（I）表示的化合物：其中Ar 1和Ar 2各自为芳基或杂芳基; R 1是低级环烷基，-Ar 3或通式（a），（b）或（c）的基团：R 2， R 3和R 3各自为氢，低级环烷基，低级烯基或任选取代的低级烷基（条件是当R 2和R 3' / SUP>同时为氢，Ar 1，Ar 2和R 1不同时表示未取代的苯基）。 这些化合物可用作各种NPY相关疾病的治疗剂，例如包括高血压，肾脏疾病，心脏病，血管痉挛和动脉硬化的循环系统疾病; 中枢神经系统疾病，包括食欲过多，抑郁，焦虑，惊厥，癫痫，痴呆，疼痛，酒精依赖以及戒毒症状; 代谢疾病包括肥胖，糖尿病，激素失调，高胆固醇血症和高脂血症; 性功能障碍和生殖功能障碍; 消化疾病包括肠动力障碍; 呼吸疾病; 炎; 或青光眼。

公开(公告)号：US08311470B2

公开(公告)日：2012-11-13

申请号：US12844008

申请日：2010-07-27

申请人： Osamu Okamoto

发明人： Osamu Okamoto

IPC分类号： G03G15/20

CPC分类号： G03G15/206

摘要： An image heating apparatus includes: a belt member; an inclinable steering roller configured to support the belt member; a heating member configured to contact the belt member and heat an image on a recording material; a detecting member configured to detect a position of a belt end in a widthwise direction of the belt member; a correcting device configured to correct a position of the belt member in the widthwise direction by inclining the steering roller in accordance with a detected position of the belt end by the detecting member; and a supporting device configured to support the detecting member. The supporting device is provided with a contact portion for press-contacting an end surface of one end portion of a pressing roller configured to press the belt member against the heating member.

摘要翻译： 图像加热装置包括：带构件; 构造成支撑所述带构件的倾斜转向辊; 加热构件，其构造成接触所述带构件并加热记录材料上的图像; 检测构件，其构造成检测所述带构件的宽度方向上的带端部的位置; 校正装置，被配置为通过根据所述检测构件的所述带端的检测位置使所述转向辊倾斜来校正所述带构件在宽度方向上的位置; 以及配置为支撑所述检测部件的支撑装置。 支撑装置设置有用于将构造成将带构件压靠加热构件的加压辊的一个端部的端面压接的接触部。

公开(公告)号：US07907383B2

公开(公告)日：2011-03-15

申请号：US12086967

申请日：2007-02-08

申请人： Masami Ando ,  Jun Miyaji ,  Osamu Okamoto

发明人： Masami Ando ,  Jun Miyaji ,  Osamu Okamoto

IPC分类号： H01T23/00 ,  C04B35/00

CPC分类号： H02N13/00 ,  C04B35/111 ,  C04B35/6455 ,  C04B2235/3232 ,  C04B2235/5445 ,  C04B2235/656 ,  C04B2235/6582 ,  C04B2235/661 ,  C04B2235/72 ,  C04B2235/77 ,  C04B2235/785 ,  C04B2235/786 ,  C04B2235/85 ,  H01L21/6833

摘要： The present invention provides an electrostatic chuck in which the surface can be kept smooth after being exposed to plasma, so as to protect a material to be clamped such as a silicon wafer from being contaminated with particles, and which is excellent in clamping and releasing a material to be clamped and easy to manufacture by low-temperature firing. The electrostatic chuck includes a dielectric material in which alumina is 99.4 wt % or more, and titanium oxide is more than 0.2 wt % and equal to or less than 0.6 wt %, wherein the electrostatic chuck's volume resistivity is 108-1011 Ωcm in room temperature, and wherein the titanium oxide segregates in boundaries of particles of the alumina.

摘要翻译： 本发明提供了一种静电卡盘，其中表面可以在暴露于等离子体之后保持光滑，以保护待被夹持的材料如硅晶片免受颗粒污染，并且夹紧和释放 待夹紧的材料并通过低温烧制容易制造。 静电卡盘包括氧化铝为99.4重量％以上，氧化钛大于0.2重量％且为0.6重量％以下的电介质材料，其中静电卡盘的体积电阻率为108-1011质量％ 室温，其中氧化钛在氧化铝颗粒的边界分离。

公开(公告)号：US20110008084A1

公开(公告)日：2011-01-13

申请号：US12827058

申请日：2010-06-30

申请人： Osamu Okamoto

发明人： Osamu Okamoto

IPC分类号： G03G15/20

CPC分类号： G03G15/2025 ,  G03G2215/2009

摘要： An image heating apparatus includes an endless belt; a rotatable member, contactable to an outer surface of the endless belt, for forming a nip in which a recording material is nipped and conveyed; a stretching member for stretching the endless belt; an urging member, contacting an inner surface of the endless belt, for urging the stretching member by movement of the endless belt so as to include a contact portion at which the urging member contacts the stretching member; a lubricant application member for applying a lubricant onto the inner surface of the endless belt; and a collecting member, contacting the stretching member at a position downstream of an area in which the stretching member contacts the endless belt and upstream of the contact portion with respect to a rotational direction of the stretching member, for collecting the lubricant from the stretching member. The collecting member includes a guiding portion for guiding the lubricant, collected from the stretching member, onto the inner surface of the endless belt.

摘要翻译： 图像加热装置包括环形带; 可旋转构件，其可接触到所述环形带的外表面，用于形成记录材料被夹持和传送的辊隙; 用于拉伸环形带的拉伸构件; 促动构件，其与所述环形带的内表面接触，用于通过所述环形带的移动来推动所述拉伸构件，以包括所述推动构件与所述拉伸构件接触的接触部; 用于将润滑剂施加到环形带的内表面上的润滑剂施加构件; 以及收集构件，其在所述拉伸构件与所述环形带接触的区域的下游位置和所述接触部分的上游侧相对于所述拉伸构件的旋转方向接触所述拉伸构件，用于从所述拉伸构件收集所述润滑剂 。 收集构件包括用于将从拉伸构件收集的润滑剂引导到环形带的内表面上的引导部分。

公开(公告)号：US20110008083A1

公开(公告)日：2011-01-13

申请号：US12821410

申请日：2010-06-23

申请人： Osamu Okamoto

发明人： Osamu Okamoto

IPC分类号： G03G15/20

CPC分类号： G03G15/206 ,  G03G2215/2009

摘要： An image heating apparatus includes a rotatable member; a belt member contactable to the rotatable member; a pressing member for pressing the belt member against the rotatable member to form a nip in which a recording material is nipped and conveyed; and a sheet member for covering a pressing surface of the pressing member at which the pressing member presses the belt member. The sheet member is mounted on the pressing member so as to have a first area in which an end portion thereof is located outside an end portion of the belt member with respect to a widthwise direction perpendicular to a conveying direction of the recording material and which includes a portion opposing the pressing surface, and so as to have a second area in which the end portion thereof is located inside the end portion of the belt member with respect to the widthwise direction.

摘要翻译： 图像加热装置包括可旋转构件; 可旋转构件可接触的带构件; 按压构件，用于将带构件压靠在可旋转构件上以形成记录材料被夹持和传送的辊隙; 以及片状部件，用于覆盖按压部件按压带部件的按压部件的按压面。 片状部件安装在按压部件上，以具有第一区域，其端部位于带部件的端部相对于与记录材料的传送方向垂直的宽度方向的外侧，并且包括 与所述按压面相对的部分，并且具有其端部相对于所述宽度方向位于所述带部件的端部内的第二区域。

公开(公告)号：US20090324933A1

公开(公告)日：2009-12-31

申请号：US12381225

申请日：2009-03-09

申请人： Hironori Hatono ,  Masahiro Mizukane ,  Osamu Okamoto

发明人： Hironori Hatono ,  Masahiro Mizukane ,  Osamu Okamoto

IPC分类号： B32B5/16 ,  B05D1/12 ,  B05C19/00

CPC分类号： B05B7/144 ,  B01J2/16 ,  B02C19/0043 ,  B02C19/065 ,  B02C19/066 ,  B05B7/1404 ,  B05B7/1445 ,  B05B12/085 ,  B05D1/12 ,  B28B19/00 ,  C23C24/04 ,  Y10T428/25 ,  Y10T428/2982

摘要： A composite structure formation method based on an aerosol deposition method by which an aerosol with brittle material fine particles dispersed in a gas is sprayed toward a substrate to form a structure made of the brittle material fine particles, the composite structure formation method includes: storing a plurality of controlled particles in a storage mechanism, the controlled particle being an assembly packed with a plurality of particles including the brittle material fine particles; supplying the controlled particles from the storage mechanism to an aerosolation mechanism; disaggregating the supplied controlled particles in the aerosolation mechanism to form an aerosol; and spraying the aerosol toward the substrate to form a composite structure having the structure and the substrate.

摘要翻译： 一种基于气溶胶沉积方法的复合结构形成方法，其中将分散在气体中的脆性材料微粒的气溶胶喷射到基板上以形成由脆性材料微粒构成的结构，所述复合结构形成方法包括： 多个受控颗粒在储存机构中，受控颗粒是装有多个包含脆性材料微粒的颗粒的组件; 将控制的颗粒从储存机构供应到气溶胶机构; 在气溶胶机构中分解供应的受控颗粒以形成气溶胶; 并将气溶胶喷射到基板上以形成具有该结构和基底的复合结构。

公开(公告)号：US07557117B2

公开(公告)日：2009-07-07

申请号：US11603147

申请日：2006-11-22

申请人： Masaya Hashimoto ,  Osamu Okamoto ,  Satoshi Ozaki ,  Hisashi Ohta

发明人： Masaya Hashimoto ,  Osamu Okamoto ,  Satoshi Ozaki ,  Hisashi Ohta

IPC分类号： A61K31/438 ,  C07D401/04

CPC分类号： C07D471/10

摘要： The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A1, A2, A3, A4 and A5 stand for optionally halogen-substituted methine, or nitrogen atom; R1 and R2 stand for lower alkyl or the like; R3 stands for hydrogen or lower alkyl; R4 and R5 stand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like]or salts thereof. These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.

摘要翻译： 本发明涉及由通式[I]表示的4-氧代咪唑烷-2-螺哌啶衍生物[其中A1，A2，A3，A4和A5代表任选卤素取代的次甲基或氮原子; R1和R2代表低级烷基等; R3代表氢或低级烷基; R4和R5代表氢，或任选被羟基取代的低级烷基，或其盐。 这些化合物作为伤害感受肽受体激动剂起作用，可用作镇痛药，缓解麻醉止痛药耐受性，缓解依赖麻醉止痛药，镇痛增强剂，抗胆固醇药，改善脑功能药物，精神分裂症药物治疗，治疗退行性神经退行性疾病药物， 抗焦虑药或抗抑郁药及其治疗尿崩症及多尿症; 等等。

公开(公告)号：US06408224B1

公开(公告)日：2002-06-18

申请号：US09708667

申请日：2000-11-09

申请人： Osamu Okamoto ,  Teruomi Nakaya ,  Heihachiro Kamimura ,  Isao Yamaguchi

发明人： Osamu Okamoto ,  Teruomi Nakaya ,  Heihachiro Kamimura ,  Isao Yamaguchi

IPC分类号： G06F1900

CPC分类号： B25J9/1661 ,  B25J9/1664 ,  B25J17/025 ,  G05B2219/33219 ,  G05B2219/34015 ,  G05B2219/36417 ,  G05B2219/39078 ,  G05B2219/40114 ,  G05B2219/40299 ,  G05B2219/40442 ,  G05B2219/40543 ,  G05B2219/40584 ,  Y10T29/53091 ,  Y10T29/53178 ,  Y10T29/53191 ,  Y10T74/19126 ,  Y10T74/20317 ,  Y10T74/20323 ,  Y10T74/20329

摘要： In a rotary articulated robot having at least a plurality of offset rotary joints in which a drive arm and driven arm are driven in rotation about an offset rotary axis inclined with respect to the arm axis, a hollow rotary shaft that is driven in rotation by a motor is arranged rotatably, being inclined, at the leading end of the arm of either the drive arm or driven arm while a rotor member to which turning effort from the hollow shaft is transmitted is fixed at the base of the other arm, said hollow rotary shaft and said rotor member constituting a high reduction ratio transmission/torque increasing mechanism. The method of control is that the operation of the joints is determined by dividing the operating region of the end effector into a plurality of blocks, the operating conditions of each joint necessary for movement to a prescribed block are converted to database form for each block, the teaching of operating points in the prescribed block region is converted to database form and a track is generated to the block of the operating region on the basis of the block region data; and when a reference point of the block is reached, the in-block operating point data is fetched.

摘要翻译： 在具有至少多个偏移旋转接头的旋转关节式机器人中，驱动臂和从动臂围绕相对于臂轴线倾斜的偏移旋转轴线旋转驱动，空心旋转轴由旋转轴旋转驱动 电动机可旋转地布置在驱动臂或从动臂的臂的前端处，同时来自中空轴的转向力的转子构件被固定在另一个臂的底部，所述中空旋转体 轴和所述转子构件构成高减速比的变速/转矩增加机构。 控制方法是通过将末端执行器的操作区域划​​分为多个块来确定关节的操作，将移动到规定块所需的每个关节的操作条件转换为每个块的数据库形式， 将规定块区域中的操作点的教导转换为数据库形式，并且基于块区域数据将轨道生成到操作区域的块; 并且当达到块的参考点时，获取块内工作点数据。