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公开(公告)号：US09278931B2
公开(公告)日：2016-03-08
申请号：US14237440
申请日：2012-08-08
申请人： Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara , Yusuke Tominari
发明人： Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara , Yusuke Tominari
IPC分类号： A61K31/167 , A61K31/435 , A61K31/415 , A61K31/382 , C07D295/14 , C07D231/14 , C07D231/56 , C07D231/20 , C07D231/22 , C07C233/80 , C07C271/22 , C07C235/56 , C07C237/40 , C07D211/98 , A61K31/36 , A61K31/366 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/4035 , A61K31/404 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4468 , A61K31/451 , A61K31/495 , A61K31/55 , C07D309/14 , C07D317/58 , C07D223/16 , C07D333/20 , C07D233/61 , C07D233/64 , C07D405/04 , C07D239/36 , C07D409/04 , C07D471/04 , C07D261/08 , C07D261/10 , C07D263/32 , C07D263/34 , C07D207/06 , C07D495/04 , C07D207/337 , C07D277/20 , C07D277/28 , C07D277/30 , C07D209/08 , C07D277/62 , C07D209/42 , C07D513/04 , C07D209/46 , C07D209/48 , C07D285/06 , C07D211/56 , C07D211/58 , C07D211/76 , C07D213/04 , C07D213/38 , C07D213/56 , C07D335/02
CPC分类号： C07C233/80 , A61K31/167 , A61K31/36 , A61K31/366 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/4035 , A61K31/404 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4468 , A61K31/451 , A61K31/495 , A61K31/55 , C07C235/56 , C07C237/40 , C07C237/42 , C07C271/20 , C07C271/22 , C07C2601/02 , C07C2601/18 , C07C2602/08 , C07D207/06 , C07D207/337 , C07D209/08 , C07D209/42 , C07D209/46 , C07D209/48 , C07D211/40 , C07D211/56 , C07D211/58 , C07D211/76 , C07D211/98 , C07D213/04 , C07D213/38 , C07D213/56 , C07D223/16 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/26 , C07D231/56 , C07D233/61 , C07D233/64 , C07D239/36 , C07D261/08 , C07D261/10 , C07D263/32 , C07D263/34 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/62 , C07D285/06 , C07D295/135 , C07D295/14 , C07D295/155 , C07D309/14 , C07D317/58 , C07D333/20 , C07D335/02 , C07D405/04 , C07D409/04 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q1, Q2, Q3 and Q4 are each a hydrogen atom or a substituent; Q1 and Q2, and Q3 and Q4, are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y1, Y2 and Y3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y1, and Y1 and Y2, are each optionally bonded to each other to form a ring optionally having substituent(s); and Z1, Z2 and Z3 are each H or a substituent, or a salt thereof.
摘要翻译： 本发明提供具有赖氨酸特异性脱甲基酶1抑制作用的化合物，可用作癌症用预防或治疗剂等中药物等中药用药物。 本发明涉及由下式表示的化合物：其中A是任选具有取代基的烃基或杂环基; R是H，任选具有取代基的烃基或杂环基; A和R可以任选地彼此键合形成任选具有取代基的环; Q1，Q2，Q3和Q4各自为氢原子或取代基; Q1和Q2以及Q3和Q4各自任选地彼此结合形成任选具有取代基的环; X是H，任选具有取代基的无环烃基或饱和环基; Y 1，Y 2和Y 3各自为H，任选具有取代基的烃基或杂环基; X和Y1以及Y 1和Y 2各自任选地彼此键合以形成任选具有取代基的环; 并且Z 1，Z 2和Z 3各自为H或取代基，或其盐。
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公开(公告)号：US20140228405A1
公开(公告)日：2014-08-14
申请号：US14237440
申请日：2012-08-08
申请人： Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara
发明人： Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara
IPC分类号： C07C233/80 , C07D231/14 , C07D335/02 , C07D211/98
CPC分类号： C07C233/80 , A61K31/167 , A61K31/36 , A61K31/366 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/4035 , A61K31/404 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4468 , A61K31/451 , A61K31/495 , A61K31/55 , C07C235/56 , C07C237/40 , C07C237/42 , C07C271/20 , C07C271/22 , C07C2601/02 , C07C2601/18 , C07C2602/08 , C07D207/06 , C07D207/337 , C07D209/08 , C07D209/42 , C07D209/46 , C07D209/48 , C07D211/40 , C07D211/56 , C07D211/58 , C07D211/76 , C07D211/98 , C07D213/04 , C07D213/38 , C07D213/56 , C07D223/16 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/26 , C07D231/56 , C07D233/61 , C07D233/64 , C07D239/36 , C07D261/08 , C07D261/10 , C07D263/32 , C07D263/34 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/62 , C07D285/06 , C07D295/135 , C07D295/14 , C07D295/155 , C07D309/14 , C07D317/58 , C07D333/20 , C07D335/02 , C07D405/04 , C07D409/04 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q1, Q2, Q3 and Q4 are each a hydrogen atom or a substituent; Q1 and Q2, and Q3 and Q4, are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y1, Y2 and Y3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y1, and Y1 and Y2, are each optionally bonded to each other to form a ring optionally having substituent(s); and Z1, Z2 and Z3 are each H or a substituent, or a salt thereof.
摘要翻译： 本发明提供具有赖氨酸特异性脱甲基酶1抑制作用的化合物，可用作癌症用预防或治疗剂等中药物等中药用药物。 本发明涉及由下式表示的化合物：其中A是任选具有取代基的烃基或杂环基; R是H，任选具有取代基的烃基或杂环基; A和R可以任选地彼此键合形成任选具有取代基的环; Q1，Q2，Q3和Q4各自为氢原子或取代基; Q1和Q2以及Q3和Q4各自任选地彼此结合形成任选具有取代基的环; X是H，任选具有取代基的无环烃基或饱和环基; Y 1，Y 2和Y 3各自为H，任选具有取代基的烃基或杂环基; X和Y1以及Y 1和Y 2各自任选地彼此键合以形成任选具有取代基的环; 并且Z 1，Z 2和Z 3各自为H或取代基，或其盐。
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