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公开(公告)号：US06849726B2
公开(公告)日：2005-02-01
申请号：US10390206
申请日：2003-03-17
IPC分类号： C12N15/09 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12N9/00 , C12N9/22 , C12N15/113 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/121 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346 , C12N2330/30 , C12Y304/24017 , C12N2310/3521
摘要： The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.
摘要翻译： 本发明涉及含有一种或多种非核苷酸模拟物的RNA分子。
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公开(公告)号：US5891683A
公开(公告)日：1999-04-06
申请号：US363253
申请日：1994-12-23
IPC分类号： C12N15/09 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12N9/00 , C12N9/22 , C12N15/113 , C12P19/34 , A01N43/04 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12Y304/24017 , C12N2310/121 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346 , C12N2330/30
摘要： Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
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公开(公告)号：US06555668B2
公开(公告)日：2003-04-29
申请号：US10041614
申请日：2002-01-08
IPC分类号： C07H2100
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/121 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346 , C12N2330/30 , C12Y304/24017 , C12N2310/3521
摘要： Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
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公开(公告)号：US6117657A
公开(公告)日：2000-09-12
申请号：US182975
申请日：1998-10-29
IPC分类号： C12N15/09 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C12N9/00 , C12N9/22 , C12N15/113 , C12P19/34 , A01N43/04 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12Y304/24017 , C12N2310/121 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346 , C12N2330/30
摘要： Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
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公开(公告)号：US06362323B1
公开(公告)日：2002-03-26
申请号：US09628959
申请日：2000-07-31
IPC分类号： C07H2100
CPC分类号： C07H21/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/121 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346 , C12N2330/30 , C12Y304/24017 , C12N2310/3521
摘要： Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
摘要翻译： 含有一个或多个非核苷酸模拟物并具有切割RNA或DNA分子的活性的酶学核酸分子。
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公开(公告)号：US06586238B1
公开(公告)日：2003-07-01
申请号：US09419125
申请日：1999-10-15
申请人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
发明人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
IPC分类号： C07H2104
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00 , C12N2310/121
摘要： An enzymatic nucleic acid molecule comprising a 5′- and/or a 3′-cap structure, wherein said structure is not a 5′-5′-linked inverted nucleotide or a 3′-3′-linked inverted nucleotide.
摘要翻译： 包含5'和/或3'帽结构的酶核酸分子，其中所述结构不是5'-5'-连接的倒置核苷酸或3'-3'-连接的倒置核苷酸。
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公开(公告)号：US20050074760A1
公开(公告)日：2005-04-07
申请号：US10430562
申请日：2003-05-06
申请人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
发明人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
IPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/04 , C12N5/00
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00 , C12N2310/121
摘要： An enzymatic nucleic acid molecule comprising a 5′- and/or a 3′-cap structure, wherein said structure is not a 5′-5′-linked inverted nucleotide or a 3′-3′-linked inverted nucleotide.
摘要翻译： 包含5'和/或3'帽结构的酶核酸分子，其中所述结构不是5'-5'-连接的倒置核苷酸或3'-3'-连接的倒置核苷酸。
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公开(公告)号：US5998203A
公开(公告)日：1999-12-07
申请号：US632882
申请日：1996-04-16
申请人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
发明人： Jasenka Matulic-Adamic , Leonid Beigelman , Alexander Karpeisky , Thale Jarvis , Nassim Usman , Anthony DiRenzo , Francine Wincott
CPC分类号： C12N15/113 , C07H19/06 , C07H19/16 , C07H21/00 , C12N2310/121
摘要： An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide.
摘要翻译： 包含5'和/或3'帽结构的酶核酸分子，其中所述结构不是5'-5'-连接的倒置核苷酸或3'-3'-连接的倒置核苷酸。
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公开(公告)号：US5672501A
公开(公告)日：1997-09-30
申请号：US541365
申请日：1995-10-05
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N15/113 , C12N5/06 , C12N15/00 , C12P19/34
CPC分类号： C12N15/1137 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N15/1138 , C12Y304/24017 , C12N2310/121 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/332 , C12N2310/346
摘要： An enzymatic nucleic acid having a modification selected from pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, 6-methyl-uracil and aminophenyl.
摘要翻译： 具有选自吡啶-4-酮，吡啶-2-酮，苯基，假尿嘧啶，2,4,6-三甲氧基苯，3-甲基尿嘧啶，二氢尿嘧啶，萘基，6-甲基 - 尿嘧啶和氨基苯基的酶的核酸。
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公开(公告)号：US06395713B1
公开(公告)日：2002-05-28
申请号：US09120520
申请日：1998-07-21
申请人： Leonid Beigelman , Jasenka Matulic-Adamic , Alex Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
发明人： Leonid Beigelman , Jasenka Matulic-Adamic , Alex Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
IPC分类号： A01N4304
CPC分类号： C07D213/64 , A61K47/54 , A61K47/542 , A61K47/543 , C07C237/06 , C07C237/22 , C07C279/04 , C07C279/12 , C07C279/14 , C07H19/06 , C07J41/0005 , C07J43/003 , C07J51/00 , C12N15/88
摘要： This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.
摘要翻译： 本发明的特征在于渗透性增强剂分子和方法，以提高带负电荷的聚合物的膜渗透性，从而促进这些聚合物的细胞摄取。
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