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1.发明授权Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 有权编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列公开(公告)号：US06822085B2
公开(公告)日：2004-11-23
申请号：US09962357
申请日：2001-09-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： C07H2104
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译： 来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法 使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针 以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。
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2.发明申请Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 审中-公开编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列公开(公告)号：US20050233424A1
公开(公告)日：2005-10-20
申请号：US10898345
申请日：2004-07-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： A23K1/00 , A23K1/16 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/88 , C12P13/08 , C12P13/12 , C07H21/04 , C12N15/74
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译： 来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法 使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针 以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。
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公开(公告)号：US07252977B2
公开(公告)日：2007-08-07
申请号：US09962618
申请日：2001-09-26
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sugar import protein K (msiK) gene, and a host-vector system having a coryneform host bacterium in which the msiK gene is present in enhanced form and a vector which carries at least the msiK gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译： 本发明涉及具有编码糖进入蛋白K（msiK）基因的多核苷酸序列的谷氨酸棒杆菌的分离的多核苷酸，以及具有其中以增强形式存在msiK基因的棒状细胞宿主细菌的宿主 - 载体系统和载体 其至少携带根据SEQ ID No 1的msiK基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。
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公开(公告)号：US06916636B2
公开(公告)日：2005-07-12
申请号：US09938641
申请日：2001-08-27
申请人： Achim Marx , Mike Farwick , Thomas Hermann , Natalie Schischka , Brigitte Bathe
发明人： Achim Marx , Mike Farwick , Thomas Hermann , Natalie Schischka , Brigitte Bathe
CPC分类号： C07K14/34
摘要： The invention relates to polynucleotides corresponding to the oxyR gene from Corynebacterium glutamicum and which encode a OxyR transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having OxyR transcriptional regulator activity.
摘要翻译： 本发明涉及对应于谷氨酸棒杆菌的oxyR基因的多核苷酸，其编码OxyR转录调节子，产生L-氨基酸的方法，以及筛选编码具有OxyR转录调节活性的蛋白质的多核苷酸的方法。
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公开(公告)号：US20100196959A1
公开(公告)日：2010-08-05
申请号：US12696449
申请日：2010-01-29
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的OpcA亚基变体的棒状杆菌细菌的opcA基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US07700313B2
公开(公告)日：2010-04-20
申请号：US11383253
申请日：2006-05-15
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的OpcA亚基变体的棒状杆菌细菌的opcA基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US08153404B2
公开(公告)日：2012-04-10
申请号：US12458966
申请日：2009-07-28
CPC分类号： C12P13/08 , C07K14/34 , C12P13/227
摘要： The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的Zwf亚基的变体的棒状细菌的zwf基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US07563602B2
公开(公告)日：2009-07-21
申请号：US12016728
申请日：2008-01-18
CPC分类号： C12P13/22 , C12N9/0006 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
摘要翻译： 本发明涉及编码6-磷酸葡萄糖酸脱氢酶的棒状细菌的gnd基因的突变体和等位基因，其含有第329位或氨基酸序列与L-缬氨酸以外的任何氨基酸的可比较位置，以及用于生产 氨基酸，优选L-赖氨酸和L-色氨酸，通过使用含有这些等位基因的细菌进行发酵。
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公开(公告)号：US20070224666A1
公开(公告)日：2007-09-27
申请号：US11790063
申请日：2007-04-23
CPC分类号： C12P13/08 , C07K14/34 , C12P13/227
摘要： The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的Zwf亚基变体的棒状细菌的zwf基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US20060246554A1
公开(公告)日：2006-11-02
申请号：US11227138
申请日：2005-09-16
CPC分类号： C12P13/22 , C12N9/0006 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
摘要翻译： 本发明涉及编码6-磷酸葡萄糖酸脱氢酶的棒状细菌的gnd基因的突变体和等位基因，其含有第329位或氨基酸序列与L-缬氨酸以外的任何氨基酸的可比较位置，以及用于生产 氨基酸，优选L-赖氨酸和L-色氨酸，通过使用含有这些等位基因的细菌进行发酵。
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