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公开(公告)号：US5480565A
公开(公告)日：1996-01-02
申请号：US134098
申请日：1993-10-08
CPC分类号： B01D65/022 , A61M1/1686 , A61M1/169 , B01D2321/16 , B01D2321/162
摘要： A method for reprocessing dialyzer cartridges used with kidney dialysis machines is provided. The method involves filling the blood and dialysate compartments of the dialyzer with an aqueous solution containing citric acid at a concentration of 1.0-5.0 wt. %, e.g., 1.5 wt. %, and then subjecting the dialyzer to an elevated temperature above 90.degree. C. and below 100.degree. C., e.g., 95.degree. C., for a period of at least 15 hours, e.g., 20 hours. Although citric acid is non-toxic and the temperature used is below the boiling point of water, the process has been found to produce a fully sterilized dialyzer. After reprocessing, the aqueous citric acid solution is preferably left in the dialyzer where it acts as a bacteriostatic agent during storage. Essentially no damage to the dialyzer and, in particular, to its semipermeable membrane results from either the reprocessing or storage procedures.
摘要翻译： 提供了一种用于肾脏透析机使用的再利用透析器盒的方法。 该方法包括用浓度为1.0-5.0wt。柠檬酸的水溶液填充透析器的血液和透析液室。 ％，例如1.5wt。 ％，然后使透析器在高于90℃和低于100℃，例如95℃的升高温度下进行至少15小时，例如20小时的时间。 虽然柠檬酸是无毒的，使用的温度低于水的沸点，但已发现该方法生产完全灭菌的透析器。 再处理后，优选将柠檬酸水溶液置于透析器中，在储存期间用作抑菌剂。 透析器基本上没有损害，特别是对其半透膜造成的后果是再次处理或储存。
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公开(公告)号：US5698100A
公开(公告)日：1997-12-16
申请号：US794293
申请日：1997-02-03
CPC分类号： B01D65/022 , A61M1/1686 , A61M1/169 , B01D2321/16 , B01D2321/162
摘要： A method for reprocessing dialyzer cartridges used with kidney dialysis machines is provided. The method involves filling the blood and dialysate compartments of the dialyzer with an aqueous solution containing citric acid at a concentration of 1.0-5.0 wt. %, e.g., 1.5 wt. %, and then subjecting the dialyzer to an elevated temperature above 90.degree. C. and below 100.degree. C., e.g., 95.degree. C., for a period of at least 15 hours, e.g., 20 hours. Although citric acid is non-toxic and the temperature used is below the boiling point of water, the process has been found to produce a fully sterilized dialyzer. After reprocessing, the aqueous citric acid solution is preferably left in the dialyzer where it acts as a bacteriostatic agent during storage. Essentially no damage to the dialyzer and, in particular, to its semipermeable membrane results from either the reprocessing or storage procedures.
摘要翻译： 提供了一种用于肾脏透析机使用的再利用透析器盒的方法。 该方法包括用浓度为1.0-5.0wt。柠檬酸的水溶液填充透析器的血液和透析液室。 ％，例如1.5wt。 ％，然后使透析器在高于90℃和低于100℃，例如95℃的升高温度下进行至少15小时，例如20小时的时间。 虽然柠檬酸是无毒的，使用的温度低于水的沸点，但已发现该方法生产完全灭菌的透析器。 再处理后，优选将柠檬酸水溶液置于透析器中，在储存期间用作抑菌剂。 透析器基本上没有损害，特别是对其半透膜造成的后果是再次处理或储存。
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公开(公告)号：US09295773B2
公开(公告)日：2016-03-29
申请号：US13884115
申请日：2011-11-09
CPC分类号： A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M39/02 , A61M2039/0258 , A61M2039/027 , A61M2039/0285 , A61M2039/0288 , A61M2039/0291 , A61M2039/0294 , A61M2205/582 , A61M2207/00
摘要： A medical blood access system used for hemodialysis treatment to enable blood withdrawal for processing of blood by an external apparatus and return the same blood to a patient, comprising an interfacial fluid conduit between the machine and patient's blood supply which is repeatedly connectable along a guided pathway passing through epidermis and subcutaneous tissue via a naturally formed tissue tract to enter blood space, providing improved patient safely, convenience, effective prophylaxis, without bleeding or tissue trauma or pain, and is executable by the patient to precisely connect and disconnect with minimal disfigurement or life restrictions, and is useable on virtually all patients soon after placement and is robust and safe to high blood flow.
摘要翻译： 一种用于血液透析治疗的医用血液存取系统，用于通过外部设备进行血液处理以取出血液，并将相同的血液返回给患者，其包括在机器和患者的血液供应之间的界面流体导管，其可沿导向路径反复连接 通过表皮和皮下组织经由天然形成的组织管道进入血液空间，提供改善的患者安全，方便，有效的预防，没有出血或组织创伤或疼痛，并且可由患者执行以最小化的形态精确连接和断开， 寿命限制，并且几乎所有患者在放置后不久可以使用，并且对于高血流量是稳健和安全的。
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4.发明申请公开(公告)号：US20100145252A1
公开(公告)日：2010-06-10
申请号：US12460787
申请日：2009-07-24
CPC分类号： A61M25/0017 , A01N43/88 , A61K31/549 , A61K38/38 , A61K47/32 , A61L2/16 , A61L29/126 , A61M1/3661 , A61M2025/0056
摘要： Catheters used for medical treatment, e.g., hemodialysis are filled with a locking solution, usually heparin between treatments. To prevent infections, antimicrobial or antibiotic substances have been used as locking solution alone or in combination with antithrombotic substances. It has been found that these locking solutions are rapidly washed out from the catheter tip. The invention describes a thixotropic gel that can be used as locking solution. Beneficial substances, e.g., antimicrobial or antibiotic substances can be added to the gel. A preferred antimicrobial substance is taurolidin alone or in combination with salicylic acid or one of its salts.
摘要翻译： 用于医疗，例如血液透析的导管填充有锁定溶液，通常在治疗之间是肝素。 为了防止感染，抗微生物剂或抗生素物质已被用作单独的锁定溶液或与抗血栓形成物质组合使用。 已经发现这些锁定溶液从导管末端快速洗出。 本发明描述了可用作锁定溶液的触变凝胶。 可以将有益物质，例如抗微生物剂或抗生素物质加入到凝胶中。 优选的抗微生物物质是单独的taurolidin或与水杨酸或其盐之一组合。
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5.发明授权公开(公告)号：US07311689B2
公开(公告)日：2007-12-25
申请号：US10642638
申请日：2003-08-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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公开(公告)号：US06803363B2
公开(公告)日：2004-10-12
申请号：US10160529
申请日：2002-05-31
IPC分类号： A61K3154
CPC分类号： A61K31/19 , A61K31/549 , A61M1/287
摘要： The present invention contemplates the addition of 0.5% to 4% taurolidine into solutions used peritoneal dialysis. The taurolidine is intended to prevent or reduce the incidence of infection within the abdomen and/or in the vicinity of an implanted dialysis port. The invention also includes methods using solutions of taurolidine in the flushing and locking of catheters and fluid lines used in peritoneal dialysis.
摘要翻译： 本发明考虑将0.5％至4％的taurolidine加入到腹膜透析溶液中。 该taurolidine旨在防止或减少在腹部和/或植入的透析口附近的感染的发生率。 本发明还包括使用taurolidine的溶液在用于腹膜透析的导管和流体管线的冲洗和锁定中的方法。
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7.发明授权公开(公告)号：US06575945B2
公开(公告)日：2003-06-10
申请号：US10140630
申请日：2002-05-08
IPC分类号： A61M3100
CPC分类号： A61L29/16 , A61L27/54 , A61L2300/104 , A61L2300/204 , A61L2300/404 , A61M39/0208
摘要： An improvement in an implantable port of the type including a housing that is implanted within a subcutaneous tissue pocket is disclosed, wherein the improvement comprises the presence of metallic silver, an inorganic silver compound, a silver salt of an organic acid, or other antimicrobial substances such as taurolidine on the surfaces of the port in contact with, or proximate to, the tissue of said pocket.
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公开(公告)号：US4997570A
公开(公告)日：1991-03-05
申请号：US431555
申请日：1989-11-03
CPC分类号： A61M1/16 , A61M1/1639 , Y10S210/929
摘要： A method and a device for ultrafiltration during hemodialysis are described in which ultrafiltrate fluid, before removal from the dialysis circuit, is passed through a balancing device, which is also used as ultrafiltrate pump. For this purpose, a controller controls and actuates inlet, outlet, and dialyzer valves, in such a way that a desired amount of ultrafiltrate, corresponding to the filling volume of a balancing chamber or a multiple thereof, is introduced to the discharge through the balancing chamber. In order to carry out continuous ultrafiltration during hemodialysis, a predetermined amount of air is introduced to the dialysis fluid flow circuit through an air separator and is then pumped off during hemodialysis so that a corresponding amount of ultrafiltrate is obtained.
摘要翻译： 描述了在血液透析期间用于超滤的方法和装置，其中在从透析回路移除之前的超滤液通过平衡装置，该平衡装置也用作超滤泵。 为此，控制器控制和致动入口，出口和透析器阀，使得对应于平衡室的填充体积或其倍数的期望量的超滤液通过平衡被引入到排出口 房间。 为了在血液透析期间进行连续超滤，通过空气分离器将预定量的空气引入透析流体回路中，然后在血液透析期间被泵送，从而获得相应量的超滤液。
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9.发明授权
公开(公告)号：US4844871A
公开(公告)日：1989-07-04
申请号：US047648
申请日：1987-05-08
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1495 , G01N33/49 , G01N33/497
CPC分类号： A61B5/14542 , A61B5/14539 , A61B5/14557 , G01N33/491 , Y10T436/11 , Y10T436/117497 , Y10T436/255
摘要： A method and an apparatus are described for determining the partial pressures of gases in blood, in which a membrane filter is used to separate plasma which passes to a blood gas analyzer.
摘要翻译： 描述了一种用于确定血液中气体分压的方法和装置，其中使用膜过滤器来分离通过血液分析仪的血浆。
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公开(公告)号：US4702829A
公开(公告)日：1987-10-27
申请号：US806073
申请日：1985-12-06
CPC分类号： B01D65/102 , A61M1/1635 , A61M1/1672 , A61M1/3413 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3465 , B01D61/142 , C02F1/444 , A61M2205/17 , A61M2205/705
摘要： Hemodiafiltration apparatus (10) comprising a closed dialysis solution cycle which has a balancing system (28), wherein into the closed cycle a first sterile filter (44) is connected from which a connecting line (74, 90, 94) leads to the venous drip chamber (114) of the blood path (102). Connected into said connecting line downstream of the first sterile filter (44) is a substituate pump (76) which is followed downstream by a second sterile filter (78).
摘要翻译： 包括具有平衡系统（28）的封闭式透析溶液循环的血液透析滤过装置（10），其中连接第一无菌过滤器（44）进入闭合循环，连接管线（74,90,94）从所述静脉 血液路径（102）的滴液室（114）。 连接到第一无菌过滤器（44）下游的所述连接管线的是代替泵（76），其随后由第二无菌过滤器（78）下游。
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