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公开(公告)号：US08642583B2
公开(公告)日：2014-02-04
申请号：US13126223
申请日：2009-10-29
申请人： Nicholas I. Carruthers , Wenying Chai , Jill A. Jablonowski , Chandravadan R. Shah , Brock T. Shireman , Devin M. Swanson , Vi T. Tran , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Jill A. Jablonowski , Chandravadan R. Shah , Brock T. Shireman , Devin M. Swanson , Vi T. Tran , Victoria D. Wong
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： C07D207/12 , A61K31/397 , A61K31/40 , A61K31/423 , A61K31/428 , A61K31/4375 , A61K31/4465 , A61K31/4725 , A61K45/06 , C07D205/04 , C07D207/24 , C07D211/42 , C07D211/46 , C07D211/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 式（I）的联苯化合物是用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号：US20110207714A1
公开(公告)日：2011-08-25
申请号：US13126223
申请日：2009-10-29
申请人： Nicholas I. Carruthers , Brock T. Shireman , Vi T. Tran , Victoria D. Wong , Jill A. Jablonowski , Wenying Chai
发明人： Nicholas I. Carruthers , Brock T. Shireman , Vi T. Tran , Victoria D. Wong , Jill A. Jablonowski , Wenying Chai
IPC分类号： A61K31/397 , C07D205/04 , C07D405/12 , C07D417/14 , A61K31/427 , C07D417/12 , A61K31/422 , C07D413/12 , A61K31/4245 , C07D401/12 , A61K31/4427 , C07D207/12 , A61K31/40 , C07D211/46 , A61K31/4465 , A61K31/4525 , A61K31/445 , A61K31/4462 , C07D471/04 , A61K31/4375 , A61K31/4725 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/00 , A61P29/00 , A61P3/04 , A61P15/00 , A61P3/00 , A61P9/10 , A61P9/00 , A61P27/02 , A61P27/06
CPC分类号： C07D207/12 , A61K31/397 , A61K31/40 , A61K31/423 , A61K31/428 , A61K31/4375 , A61K31/4465 , A61K31/4725 , A61K45/06 , C07D205/04 , C07D207/24 , C07D211/42 , C07D211/46 , C07D211/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 式（I）的联苯化合物是用于治疗5-羟色胺介导的疾病的血清素调节剂。
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3.发明授权Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor 有权取代的哌嗪和哌啶作为神经肽Y2受体的调节剂公开(公告)号：US08183239B2
公开(公告)日：2012-05-22
申请号：US11553556
申请日：2006-10-27
申请人： Pascal Bonaventure , Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , Jill A. Jablonowski , Dale A. Rudolph , Mark Seierstad , Chandravadan R. Shah , Devin M. Swanson , Victoria D. Wong
发明人： Pascal Bonaventure , Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , Jill A. Jablonowski , Dale A. Rudolph , Mark Seierstad , Chandravadan R. Shah , Devin M. Swanson , Victoria D. Wong
IPC分类号： A61K31/495 , A61K31/496 , A61K31/5377 , C07D211/34 , C07D211/58 , C07D213/56 , C07D295/15 , C07D401/04 , A61K31/451 , A61K31/454 , C07D401/12 , C07D417/12
CPC分类号： C07D295/15 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D207/34 , C07D211/14 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/58 , C07D211/70 , C07D213/55 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/14 , C07D237/20 , C07D239/28 , C07D239/48 , C07D241/04 , C07D261/08 , C07D261/14 , C07D285/01 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/24 , C07D307/52 , C07D307/68 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/08
摘要： The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility. The compounds of the present invention are of the formula where Ring T is a heterocycloalkyl ring selected from the group consisting of:
摘要翻译： 本发明提供了用于治疗或预防：抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 睡眠/觉醒障碍 心血管疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能，特别是由垂体和下丘脑腺体控制的内分泌功能，因此可用于治疗或预防排卵和不育症。 本发明的化合物具有下式：其中环T是选自以下的杂环烷基环：
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4.发明申请PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 审中-公开作为神经元Y2受体的调节剂有用的哌嗪衍生物公开(公告)号：US20120129870A1
公开(公告)日：2012-05-24
申请号：US12809023
申请日：2008-12-17
申请人： Wenying Chai , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Devin M. Swanson , Victoria D. Wong
发明人： Wenying Chai , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Devin M. Swanson , Victoria D. Wong
IPC分类号： A61K31/496 , C07D295/135 , A61K31/495 , C07D405/12 , C07D401/06 , C07D417/06 , C07D403/06 , A61K31/506 , C07D413/14 , C07D405/06 , A61P25/22 , A61P25/24 , A61P9/00 , A61P19/10 , A61P5/00 , A61P25/32 , A61P3/04 , A61P15/08 , A61P25/00 , A61P29/00 , C07D409/06 , C07D401/14 , C07D295/15 , C07D413/06
CPC分类号： C07D271/06 , C07D213/38 , C07D233/64 , C07D239/26 , C07D263/16 , C07D263/32 , C07D263/56 , C07D271/10 , C07D277/28 , C07D277/64 , C07D295/073 , C07D295/135 , C07D295/15 , C07D295/155 , C07D307/14 , C07D307/54 , C07D333/20 , C07D413/04 , C07D413/12
摘要： The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
摘要翻译： 本发明涉及可用作NPY Y2受体的抑制剂的式（II）的哌啶基和哌嗪基衍生物，包含所述化合物的药物组合物，所述化合物的制备方法和所述化合物用于治疗和/或预防的用途 由NPY Y2受体介导的疾病，疾病和病症。
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5.发明申请PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 审中-公开作为神经元Y2受体的调节剂有用的哌嗪衍生物公开(公告)号：US20120015957A1
公开(公告)日：2012-01-19
申请号：US12809010
申请日：2008-12-17
申请人： Wenying Chai , Curt A. Dvorak , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Victoria D. Wong
发明人： Wenying Chai , Curt A. Dvorak , Jill A. Jablonowski , Dale A. Rudolph , Chandravadan R. Shah , Victoria D. Wong
IPC分类号： A61K31/496 , C07D403/10 , C07D413/14 , C07D295/15 , A61K31/495 , C07D401/10 , C07D417/10 , A61P25/22 , A61P25/24 , A61P25/00 , A61P19/08 , A61P9/00 , A61P25/30 , A61P3/04 , A61P5/00 , A61P15/08 , A61P25/32 , C07D413/10
CPC分类号： C07D271/06 , C07D207/335 , C07D213/38 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/16 , C07D263/32 , C07D263/34 , C07D271/07 , C07D271/10 , C07D275/02 , C07D285/08 , C07D295/15
摘要： The present invention is directed to piperidinyl and piperazinyl derivatives of formula (I) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
摘要翻译： 本发明涉及可用作NPY Y2受体的抑制剂的式（I）的哌啶基和哌嗪衍生物，包含所述化合物的药物组合物，所述化合物的制备方法和所述化合物用于治疗和/或预防的用途 由NPY Y2受体介导的疾病，疾病和病症。
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公开(公告)号：US20090270370A1
公开(公告)日：2009-10-29
申请号：US12496866
申请日：2009-07-02
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , A61K31/55 , A61K31/4162
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号：US20110040088A1
公开(公告)日：2011-02-17
申请号：US12911523
申请日：2010-10-25
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Ovorak , Annette K. Kwok , Jimmiy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Ovorak , Annette K. Kwok , Jimmiy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号：US07897771B2
公开(公告)日：2011-03-01
申请号：US12496866
申请日：2009-07-02
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： C07D417/02 , A01N43/42
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号：US07402680B2
公开(公告)日：2008-07-22
申请号：US10941664
申请日：2004-09-15
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： C07D471/02
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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10.发明申请PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 有权作为神经元Y2受体的调节剂有用的哌嗪衍生物公开(公告)号：US20110046151A1
公开(公告)日：2011-02-24
申请号：US12667578
申请日：2008-06-26
IPC分类号： A61K31/496 , C07D401/12 , A61P25/00 , A61P25/30 , A61P25/24 , A61P29/00 , A61P3/04 , A61P19/08 , A61P9/00 , A61P15/08
CPC分类号： C07D213/56 , C07D295/145
摘要： The present invention is directed to piperazinyl derivatives useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
摘要翻译： 本发明涉及可用作NPY Y2受体的抑制剂的哌嗪衍生物，包含所述化合物的药物组合物，所述化合物的制备方法和所述化合物用于治疗和/或预防疾病，疾病和病症介导的用途 由NPY Y2受体。
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