公开(公告)号：US5454971A

公开(公告)日：1995-10-03

申请号：US67075

申请日：1993-05-26

申请人： Nobuaki Sakai ,  Masahiro Suzuki ,  Tatsuya Mizukoshi ,  Yukie Goto ,  Keijitsu Tanaka ,  Michihiro Takama ,  Norio Moriya ,  Kazunori Sakimoto

发明人： Nobuaki Sakai ,  Masahiro Suzuki ,  Tatsuya Mizukoshi ,  Yukie Goto ,  Keijitsu Tanaka ,  Michihiro Takama ,  Norio Moriya ,  Kazunori Sakimoto

IPC分类号： C11D3/386 ,  C12N9/20 ,  C11D17/00 ,  C12N1/00 ,  D06M16/00

CPC分类号： C12R1/38 ,  C11D3/38627 ,  C12N9/20 ,  Y10S435/874

摘要： A microorganism belonging to the genus Pseudomonas; an alkaline lipase produced by the microorganism or its mutants; a method of producing the alkaline lipase; and detergents containing the alkaline lipase as an aid, the alkaline lipase having (1) an operative pH of from 4 to 11.5, and an optimum pH of from 7.0 to 9.5, as measured using triolein emulsion as a substrate; (2) an operative temperature of from 10.degree. to 80.degree. C., and an optimum temperature of from 55.degree. to 65.degree. C., as measured using triolein emulsion as a substrate; (3) a molecular weight of 28,000 .+-.2,000 as measured by electrophoresis using SDS polyacrylamide; (4) isoelectric point of 4.5 .+-.1.5 as measured by isoelectric focusing polyacrylamide gel electrophoresis; and (5) an inhibition of lipase activity by a detergent component of not higher than 50% as measured using sodium linear-alkylbenzenesulfonate as said detergent component.The alkaline lipase has an improved stability against detergent components such as a surfactant and a protease, and can be blended with a detergent together with a protease. The alkaline lipase is less susceptible to inhibition of lipase activity by a detergent component and can increase washing power of detergents.

摘要翻译： 属于假单胞菌属的微生物; 由微生物或其突变体产生的碱性脂肪酶; 一种生产碱性脂肪酶的方法; 和含有碱性脂肪酶的洗涤剂作为辅助剂，所述碱性脂肪酶具有（1）操作pH为4至11.5，最佳pH为7.0至9.5，使用三油酸酯乳液作为底物; （2）使用三油精乳液作为底物测定的操作温度为10℃至80℃，最适温度为55℃至65℃; （3）通过使用SDS聚丙烯酰胺的电泳测量的分子量为28,000 +/- 2,000; （4）通过等电聚焦聚丙烯酰胺凝胶电泳测量的等电点为4.5 +/- 1.5; 和（5）使用直链烷基苯磺酸钠作为所述洗涤剂组分测定的洗涤剂组分对脂肪酶活性的抑制不高于50％。 碱性脂肪酶对洗涤剂组分如表面活性剂和蛋白酶具有改善的稳定性，并且可与蛋白酶一起与洗涤剂共混。 碱性脂肪酶不太容易被洗涤剂组分抑制脂肪酶活性，并且可以提高洗涤剂的洗涤能力。

公开(公告)号：US6097197A

公开(公告)日：2000-08-01

申请号：US907191

申请日：1997-08-06

申请人： Katsuhiro Matsuyama ,  Nobuaki Sakai ,  Seizo Morita ,  Yasuhiro Sugawara

发明人： Katsuhiro Matsuyama ,  Nobuaki Sakai ,  Seizo Morita ,  Yasuhiro Sugawara

IPC分类号： G01B21/30 ,  G01N37/00 ,  G01Q30/04 ,  G01Q60/30 ,  G01Q90/00 ,  G01R31/302 ,  G01R31/02 ,  G01R31/305 ,  G03N23/00

CPC分类号： G01Q60/30 ,  B82Y35/00 ,  Y10S977/852

摘要： A conductive cantilever having a conductive probe on its free end is supported by a piezoelectric element, which oscillates upon reception of an AC voltage from a first AC voltage supply unit. An AC voltage is applied between a conductive sample and the probe by a variable DC voltage supply unit and a second AC voltage supply unit. An AM demodulator demodulates a signal from a displacement meter at an angular frequency of the first AC voltage supply unit. A lowpass filter extracts a DC component from an output signal from the AM demodulator, and a synchronism detector extracts a component concerning to the angular frequency twice as high as that of the second AC voltage supply unit from the AM demodulator output signal. A Z controller controls a position of a tube scanner based on an output signal from the subtracter which subtracts an output signal of the synchronism detector from an output signal of the lowpass filter. A data processing unit maps configuration data from the Z controller and surface potential data from a voltage control circuit, referring to XY data from an XY scanning circuit, such that a configuration image and a potential distribution image of the sample are obtained.

摘要翻译： 在其自由端具有导电探针的导电悬臂由压电元件支撑，该压电元件在接收到来自第一AC电压供应单元的AC电压时振荡。 通过可变直流电压供应单元和第二交流电压供应单元在导电样品和探针之间施加交流电压。 AM解调器以位于第一AC电压供应单元的角频率处的来自位移计的信号解调。 低通滤波器从AM解调器的输出信号中提取DC分量，同步检测器从AM解调器输出信号中提取与第二AC电压供给单元的角频率相关的分量的两倍。 Z控制器基于来自减法器的输出信号控制管扫描器的位置，该输出信号从低通滤波器的输出信号中减去同步检测器的输出信号。 参考XY扫描电路的XY数据，数据处理单元将来自Z控制器的配置数据和来自电压控制电路的表面电位数据进行映射，从而获得样品的配置图像和电位分布图像。

公开(公告)号：US5386720A

公开(公告)日：1995-02-07

申请号：US197352

申请日：1994-02-16

申请人： Akitoshi Toda ,  Michio Takayama ,  Katsuhiro Matsuyama ,  Nobuaki Sakai ,  Yasushi Nakamura

发明人： Akitoshi Toda ,  Michio Takayama ,  Katsuhiro Matsuyama ,  Nobuaki Sakai ,  Yasushi Nakamura

IPC分类号： G01Q20/00 ,  G01Q20/04 ,  G01Q60/38 ,  H01J37/26 ,  G01B5/28

CPC分类号： G01Q20/04 ,  B82Y35/00 ,  G01Q60/38 ,  Y10S977/873

摘要： An integrated AFM sensor includes a cantilever which has two beams extending from a support portion. The beams are integrated with each other at their ends to form a triangular free end, and a probe having a sharp distal end is arranged at the free end. The cantilever is formed by stacking a passivation layer, a piezoresistive layer, and a silicon layer. Electrodes electrically connected to the piezoresistive layer are formed at the fixed end of the cantilever through contact holes.

摘要翻译： 集成AFM传感器包括悬臂，其具有从支撑部分延伸的两个梁。 梁在其端部彼此一体地形成三角形自由端，并且在自由端设置具有尖锐远端的探针。 悬臂通过堆叠钝化层，压阻层和硅层形成。 电连接到压阻层的电极通过接触孔形成在悬臂的固定端。

公开(公告)号：US07085030B2

公开(公告)日：2006-08-01

申请号：US10103311

申请日：2002-03-21

申请人： Nobuaki Sakai

发明人： Nobuaki Sakai

IPC分类号： G02B26/08

CPC分类号： G02B26/105 ,  G02B26/085

摘要： An optical scanner driving apparatus comprises a moving plate having a reflection plane and a driving coil, a magnetic field generating section arranged in a vicinity of the moving plate, a driving circuit to supply a driving signal to the driving coil, a first output acquiring section to acquire an output containing an electromotive force generated in the driving coil by an electromagnetic induction, a second output acquiring section comprising an impedance element having a corresponding impedance to an impedance of the driving coil, to acquire an output generated by the impedance element by supplying the driving signal to the impedance element, and a control circuit to control a state of the torsional vibration of the moving plate according to the electromotive force generated in the driving coil on the basis of the outputs acquired by the first output acquiring section and the second output acquiring section.

公开(公告)号：US06980359B2

公开(公告)日：2005-12-27

申请号：US10794163

申请日：2004-03-04

申请人： Takashi Yoneyama ,  Nobuaki Sakai

发明人： Takashi Yoneyama ,  Nobuaki Sakai

IPC分类号： G02B21/24 ,  G02B21/26 ,  G02B21/00

CPC分类号： G02B21/26 ,  G02B21/24

摘要： In a microscope system in which at least one of a stage on which a sample 4 is mounted and an objective lens 6 can move relatively in a direction of an optical axis, a contact judgment section 12 judges the possibility of contact between the sample 4 and the objective lens 6 based on a result of comparison between a detection output from a contact sensor 11 which detects contact between the sample 4 and the objective lens 6 and a preset threshold value, excessive contact between the sample 4 and the objective lens 6 is avoided based on a result of this judgment, and a threshold value in the contact judgment section 12 is updated based on the output from the contact sensor 11 every predetermined time.

摘要翻译： 在其中安装有样品4的阶段和物镜6可以沿光轴方向相对移动的阶段中的至少一个的显微镜系统中，接触判断部12判断样品4与样品4之间的接触的可能性 物镜6基于来自检测样品4与物镜6之间的接触的接触传感器11的检测输出与预设阈值之间的比较结果，避免了样品4与物镜6之间的过度接触 基于该判定结果，根据来自接触传感器11的每一预定时间的输出来更新接触判定部12中的阈值。

公开(公告)号：US5929643A

公开(公告)日：1999-07-27

申请号：US757131

申请日：1996-12-03

申请人： Nobuaki Sakai ,  Katsuhiro Matsuyama

发明人： Nobuaki Sakai ,  Katsuhiro Matsuyama

IPC分类号： G01Q20/00 ,  G01R1/067 ,  G01R11/00

CPC分类号： G01R1/06705 ,  B82Y35/00 ,  G01Q60/30 ,  Y10S977/852 ,  Y10S977/864

摘要： A scanning probe microscope for measuring the electrical properties of the surface of a sample comprises a first sensor for detecting electrical information for the sample surface and outputting a first electrical signal corresponding thereto, the first sensor including an electrically conductive probe located near the surface of the sample, a second sensor for detecting the distance between the probe and the sample and outputting a second electrical signal corresponding thereto, an actuator for relatively moving the probe and the sample in a three-dimensional manner, a servo control mechanism for adjusting the distance between the probe and the sample to a desired value by servo control in accordance with the second electrical signal while the electrical information is being detected by the first sensor, and a processing unit for processing the first electrical signal.

摘要翻译： 用于测量样品表面的电性能的扫描探针显微镜包括用于检测样品表面的电信息并输出与其对应的第一电信号的第一传感器，所述第一传感器包括位于所述样品表面的表面附近的导电探针 样品，用于检测探针和样品之间的距离并输出与其对应的第二电信号的第二传感器，用于以三维方式相对移动探针和样品的致动器，用于调节探针和样品之间的距离的伺服控制机构， 所述探针和所述样品在所述电信息被所述第一传感器检测到的同时根据所述第二电信号进行伺服控制而达到期望值;以及处理单元，用于处理所述第一电信号。

公开(公告)号：US06775039B2

公开(公告)日：2004-08-10

申请号：US10193684

申请日：2002-07-12

申请人： Nobuaki Sakai

发明人： Nobuaki Sakai

IPC分类号： G02B2608

CPC分类号： G02B26/105 ,  G02B7/1821

摘要： A driving circuit for an optical scanner includes an oscillation driving device for oscillating a moving plate, an oscillation detecting device for detecting the oscillating condition of the moving plate, an oscillating frequency control device for controlling the amplitude of a torsional oscillation of the moving plate, and an oscillating amplitude control device for controlling the amplitude of the torsional oscillation of the moving plate. The driving circuit is thus constructed so that the oscillation of a scanner can be controlled with a high degree of accuracy.

摘要翻译： 光扫描器的驱动电路包括振荡移动板的振荡驱动装置，用于检测移动板的振荡状态的振荡检测装置，用于控制移动板的扭转振动幅度的振荡频率控制装置， 以及用于控制移动板的扭转振动的振幅的振荡幅度控制装置。 因此，驱动电路被构造成可以高精度地控制扫描仪的振荡。

公开(公告)号：US5543614A

公开(公告)日：1996-08-06

申请号：US327193

申请日：1994-10-21

申请人： Hirofumi Miyamoto ,  Mitsugu Sakai ,  Mitsumori Hayashida ,  Nobuaki Sakai

发明人： Hirofumi Miyamoto ,  Mitsugu Sakai ,  Mitsumori Hayashida ,  Nobuaki Sakai

IPC分类号： G01B7/34 ,  G01B21/30 ,  G01N23/00 ,  G01Q10/04 ,  G01Q20/04 ,  G01Q30/06 ,  G01Q60/10 ,  G01Q60/24 ,  G01Q60/50 ,  G01Q70/04 ,  H01J37/28

CPC分类号： G01Q70/04 ,  B82Y35/00 ,  G01Q30/06 ,  Y10S977/837 ,  Y10S977/849 ,  Y10S977/851 ,  Y10S977/86 ,  Y10S977/872 ,  Y10S977/873

摘要： A scanning probe microscope having a probe for scanning a sample, a piezoelectric unit finely movable in the X, Y and Z directions, and a probe control unit for controlling a fine movement amount of the piezoelectric unit in the Z direction in accordance with a detected interaction between the sample and the probe. A driving unit applies a continuously changing voltage to the piezoelectric unit to drive the piezoelectric unit in one of an X and Y direction to scan along a scan line, a displacement detection unit detects the displacement of the piezoelectric unit along the scan line, and a matching detection unit outputs a coincidence detection signal when the detected displacement of the piezoelectric unit along the scan line coincides with target displacement values corresponding to desired measurement points. A surface data acquiring unit acquires sample surface data based on the Z-directional fine movement amount of the piezoelectric unit each time the matching detection unit outputs a coincidence detection signal.

摘要翻译： 一种扫描探针显微镜，具有用于扫描样品的探针，可在X，Y和Z方向上可移动的压电单元，以及用于根据检测到的控制压电单元在Z方向上的微小移动量的探针控制单元 样品与探针之间的相互作用。 驱动单元向压电单元施加连续变化的电压，以驱动压电单元沿X方向和Y方向中的一方沿扫描线扫描，位移检测单元检测压电单元沿着扫描线的位移，并且 当检测到的压电单元沿着扫描线的位移与对应于期望的测量点的目标位移值一致时，匹配检测单元输出一致检测信号。 表面数据获取单元每当匹配检测单元输出一致检测信号时，基于压电单元的Z方向精细移动量来获取样本表面数据。