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公开(公告)号：US6104027A
公开(公告)日：2000-08-15
申请号：US92258
申请日：1998-06-05
CPC分类号： H01J49/0036
摘要： Method for identifying low charge, low weight ions with multiple charge states in mass spectrographic analysis. Ions are matched to a charge series by testing peak width, isotope spacing, and isotope ratios, using instrument resolution and information derived from the instrument spectrum. By following these tests erroneous assignment of ions to a series are avoided, providing higher quality data to the user.
摘要翻译： 用于在质谱分析中识别具有多种电荷状态的低电荷，低重量离子的方法。 通过使用仪器分辨率和从仪器光谱得到的信息，通过测试峰宽，同位素间距和同位素比，将离子与电荷序列匹配。 通过遵循这些测试，避免了将离子错误地分配给一系列，为用户提供更高质量的数据。
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公开(公告)号：US07550259B2
公开(公告)日：2009-06-23
申请号：US11484912
申请日：2006-07-12
IPC分类号： C12Q1/00
CPC分类号： G01N33/6848 , B01L3/5027 , G01N27/447 , G01N30/7233 , G01N33/6851 , H01J49/04
摘要： A method of analyzing a sample comprising multiple protein species is provided. The proteins are separated by species such that the multiple protein species emerge in a sequential order and are then digested in the sequential order in which they emerge from the separation process. The digested proteins are introduced into a mass spectrometer in the same sequential order so that, within a given time window, the digested proteins introduced into the mass spectrometer are covariant.
摘要翻译： 提供了分析包含多种蛋白质种类的样品的方法。 蛋白质被物种分离，使得多个蛋白质物质以顺序排列出来，然后以从分离过程中出现的顺序消化。 将消化的蛋白质以相同的顺序引入质谱仪，使得在给定的时间窗口内，引入质谱仪的消化蛋白质是共变的。
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公开(公告)号：US20080014603A1
公开(公告)日：2008-01-17
申请号：US11484912
申请日：2006-07-12
IPC分类号： C12Q1/37
CPC分类号： G01N33/6848 , B01L3/5027 , G01N27/447 , G01N30/7233 , G01N33/6851 , H01J49/04
摘要： A method of analyzing a sample comprising multiple protein species is provided. The proteins are separated by species such that the multiple protein species emerge in a sequential order and are then digested in the sequential order in which they emerge from the separation process. The digested proteins are introduced into a mass spectrometer in the same sequential order so that, within a given time window, the digested proteins introduced into the mass spectrometer are covariant.
摘要翻译： 提供了分析包含多种蛋白质种类的样品的方法。 蛋白质被物种分离，使得多个蛋白质物质以顺序排列出来，然后以从分离过程中出现的顺序消化。 将消化的蛋白质以相同的顺序引入质谱仪，使得在给定的时间窗口内，引入质谱仪的消化蛋白质是共变的。
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4.发明授权Apparatuses, methods and compositions for ionization of samples and mass calibrants 有权用于电离样品和质量卡尺的装置，方法和组合物公开(公告)号：US07737395B2
公开(公告)日：2010-06-15
申请号：US11757369
申请日：2007-06-02
IPC分类号： B01D59/44
CPC分类号： H01J49/168 , H01J49/0009
摘要： The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.
摘要翻译： 本发明尤其提供了用于电离处于气相或可蒸发/升华的样品的装置和方法。 样品包括要分析的样品和用作标准品的质量标准。 此外，本发明还提供了以缓慢且受控的方式释放大量校准物的校准剂制剂。
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公开(公告)号：US20080067356A1
公开(公告)日：2008-03-20
申请号：US11523963
申请日：2006-09-20
IPC分类号： H01J49/04
CPC分类号： H01J49/02 , H01J49/0009
摘要： An apparatus for ionizing an analyte sample with a mass calibrant is provided. The apparatus includes an ionization chamber defining an ionization region, a first passageway coupled to the ionization region for delivering the analyte sample to the ionization region, a second passageway leading to a mass analyzer having an orifice arranged adjacent to the ionization region to receive ions from the ionization region, a third passageway coupled to the ionization chamber at a first end and having a second end with an orifice arranged to receive gaseous neutral mass calibrant molecules, and an ionization device arranged within the ionization chamber. The ionization device generates primary ions from the analyte sample, and the primary ions ionize a portion of the gaseous neutral mass calibrant molecules received into the ionization region via the third passageway.
摘要翻译： 提供了一种用质量校准物离子化分析物样品的装置。 该装置包括限定电离区域的电离室，耦合到离子化区域的用于将分析物样品输送到电离区域的第一通道，通向质量分析器的第二通道，该质量分析器具有邻近离子化区域布置的孔口， 电离区域，第三通道，其在第一端处耦合到电离室，并且具有布置成接收气态中性质量校准物分子的孔的第二端，以及布置在电离室内的电离装置。 离子化装置从分析物样品产生初级离子，并且初级离子通过第三通道将接收到电离区的气态中性质量校准物分子的一部分电离。
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公开(公告)号：US6167568A
公开(公告)日：2000-12-26
申请号：US107245
申请日：1998-06-30
申请人： Deborah E. Gandel , Katherine V. G. Dickinson , Christine A. Miller , Daniel P. Gilliland , Jasmine Ocegueda , Jay D. Hastings , Karin Ellison , Shelley F. Pavela , Kenneth J. Poje , Gary E. Linnert , John L. Barker
发明人： Deborah E. Gandel , Katherine V. G. Dickinson , Christine A. Miller , Daniel P. Gilliland , Jasmine Ocegueda , Jay D. Hastings , Karin Ellison , Shelley F. Pavela , Kenneth J. Poje , Gary E. Linnert , John L. Barker
CPC分类号： G06F11/3664 , G06F8/61 , G06F11/3688 , G06F21/53 , G06F2221/2137 , G06Q30/06 , G06Q30/0601 , Y10S707/99939
摘要： An embodiment consistent with the present invention includes a method and apparatus for performing software distribution of a software product electronically. Readiness criteria information associated with the software product is received via software in a data processing system. The readiness criteria information is posted in a central location. A private environment is then provided within the data processing system for accommodating an online site. The online site, which contains links to the software product in accordance with the readiness criteria information, is installed into the private environment. The online site is tested in the private environment in accordance with the UAT criteria information. When the online site meets the readiness and UAT criteria, a public environment is provided with access to the online site.
摘要翻译： 与本发明一致的实施例包括用于以电子方式执行软件产品的软件分发的方法和装置。 通过软件在数据处理系统中接收与软件产品相关联的准备条件信息。 准备条件信息被张贴在中央位置。 然后在数据处理系统内提供私人环境以容纳在线站点。 根据准备条件信息将包含指向软件产品的链接的在线站点安装到私人环境中。 在线站点根据UAT标准信息在私人环境中进行测试。 当在线网站符合准备状态和UAT标准时，公共环境可以访问在线网站。
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公开(公告)号：US07592154B2
公开(公告)日：2009-09-22
申请号：US11498208
申请日：2006-08-01
CPC分类号： C12Q1/18 , C12Q1/6897 , G01N2800/44
摘要： Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a mechanism that normally activates the bacterial SOS response or by inhibiting steps in the SOS response pathway itself. SOS response induction can result from exposure of bacteria to certain antibiotics, including β-lactam antibiotics and other agents that affect cell wall synthesis. By transiently delaying bacterial cell division, SOS response induction interferes with bacterial killing by ordinarily lethal concentrations of these drugs A pharmaceutical composition comprising an SOS targeted agent is administered to a patient suffering from a microbial infection, in combination with an antibiotic that induces an SOS response. The identification of the SOS pathway as a target for modulating antibiotic action provides a basis for further therapeutic development, through screening assays designed to detect molecules or genes that act on these pathways.
摘要翻译： 提供了组合物和方法，用于在抗微生物制剂中使用SOS途径靶向剂。 通过破坏通常激活细菌SOS反应或通过抑制SOS反应途径本身的步骤的机制，细菌对抗生素的天生敏感性增加。 SOS反应诱导可能是由细菌暴露于某些抗生素，包括β-内酰胺抗生素和影响细胞壁合成的其他药物引起的。 通过暂时延迟细菌细胞分裂，SOS反应诱导通过这些药物的通常致死浓度干扰细菌杀伤。将包含SOS靶向药物的药物组合物施用于患有微生物感染的患者与引起SOS反应的抗生素组合 。 作为调节抗生素作用靶标的SOS途径的鉴定为进一步治疗发展提供了依据，通过设计用于检测作用于这些途径的分子或基因的筛选试验。
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8.发明申请APPARATUSES, METHODS AND COMPOSITIONS FOR IONIZATION OF SAMPLES AND MASS CALIBRANTS 有权用于离子化和大量校准的装置，方法和组合物公开(公告)号：US20080067336A1
公开(公告)日：2008-03-20
申请号：US11757369
申请日：2007-06-02
CPC分类号： H01J49/168 , H01J49/0009
摘要： The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.
摘要翻译： 本发明尤其提供了用于电离处于气相或可蒸发/升华的样品的装置和方法。 样品包括要分析的样品和用作标准品的质量标准。 此外，本发明还提供了以缓慢且受控的方式释放大量校准物的校准剂制剂。
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