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    Signal processing apparatus including redundant first and second system with a duplex package configuration
    1.
    发明授权
    Signal processing apparatus including redundant first and second system with a duplex package configuration 失效
    信号处理装置，包括具有双工封装配置的冗余第一和第二系统

    公开(公告)号：US5619641A

    公开(公告)日：1997-04-08

    申请号：US365982

    申请日：1994-12-28

    申请人： Noriaki Ohuchi ,  Akio Morimoto ,  Hiroshi Yamasaki ,  Takahiro Hosokawa ,  Hiroyuki Kaneko

    发明人： Noriaki Ohuchi ,  Akio Morimoto ,  Hiroshi Yamasaki ,  Takahiro Hosokawa ,  Hiroyuki Kaneko

    IPC分类号： G06F11/18 ,  G06F11/20 ,  G06F13/00 ,  H04L1/22 ,  G06F11/00 ,  G06F11/16

    CPC分类号： G06F11/20

    摘要： A failure detection system detects a failure of a package in a redundant system having a duplex package configuration. The failure detection system includes a first package including a signal processor for carrying out a predetermined signal processing on an input signal to the first package, where the first package is provided in each of first and second systems, a second package including a selector for selectively outputting an output signal of the signal processor of the first package in one of the first and second systems in response to a control signal, a failure detector for detecting a failure in the output signal of the signal processor of the first package in each of the first and second systems and for outputting a failure detection signal if the failure is detected, and a signal processor for carrying out a predetermined signal processing on the output signal of the selector, where the second package is provided in each of first and second systems, and a controller for supplying the control signal to the selector of the second package in each of the first and second systems based on the failure detection signal received from the second package in each of the first and second systems, so that the selector selectively outputs the output signal of the signal processor of the first package in an active one of the first and second systems. The controller includes a mechanism for disregarding the failure detection signal received from the second package during a predetermined time in response to a predetermined signal. This predetermined signal may indicate which one of the first and second systems is active or, indicate whether or not the second package of each of the first and second systems is mounted on a unit to which the first package of each of the first and second systems is mounted.

    摘要翻译： 故障检测系统检测具有双工包配置的冗余系统中的包的故障。 故障检测系统包括：第一包装，包括信号处理器，用于对第一包装件的输入信号进行预定的信号处理，其中在第一和第二系统的每一个中提供第一包装;第二包装，包括选择器，用于选择性地 响应于控制信号在第一和第二系统中的一个系统中输出第一包装信号处理器的输出信号;故障检测器，用于检测第一包装的信号处理器的输出信号的故障， 第一和第二系统，并且用于在检测到故障时输出故障检测信号;以及信号处理器，用于对选择器的输出信号执行预定的信号处理，其中第二封装设置在第一和第二系统中的每一个中， 以及控制器，用于基于所述第一和第二系统将所述控制信号提供给所述第二和第二系统中的所述第二包的选择器 在第一和第二系统中的每一个中从第二包装接收的诱饵检测信号，使得选择器选择性地将第一包装的信号处理器的输出信号输出到第一和第二系统中的有效一个中。 控制器包括用于在预定时间内响应于预定信号而忽略从第二包装接收的故障检测信号的机构。 该预定信号可以指示第一和第二系统中的哪一个是活动的，或者指示第一和第二系统中的每一个的第二封装是否安装在第一和第二系统中的每一个的第一封装的单元上 被安装。

    Clock distribution system
    2.
    发明授权
    Clock distribution system 失效
    时钟分配系统

    公开(公告)号：US5274677A

    公开(公告)日：1993-12-28

    申请号：US752124

    申请日：1991-08-29

    申请人： Noriaki Ohuchi ,  Akio Morimoto ,  Hiroshi Nakaide ,  Fumihiko Saito ,  Hiroyuki Kaneko

    发明人： Noriaki Ohuchi ,  Akio Morimoto ,  Hiroshi Nakaide ,  Fumihiko Saito ,  Hiroyuki Kaneko

    IPC分类号： G06F1/10 ,  H04L7/00 ,  H04L7/04

    CPC分类号： G06F1/10

    摘要： A clock distribution system includes a clock generation and distribution part for generating a clock signal and distributing the generated clock signal to a plurality of destinations, slots in each of which a clock reception unit can be detachably mounted, and a plurality of transmission lines coupling the clock generation and distribution part to the slots. Each slot includes a circuit for generating a mount state signal which indicates whether or not the slot is mounted with a clock reception unit, and for supplying the mount state signal to the clock generation and distribution part via a transmission line. This mount state signal has a first state when no clock receiving unit is mounted in the slot and has a second state when a clock receiving unit is mounted in the slot. The clock generation and distribution part includes a circuit for receiving the mount state signal from each slot and for transmitting via the transmission line the clock signal to each slot from which a mount state signal having the second state is received.

    BIOLOGICAL SUBSTANCE DETECTION METHOD
    3.
    发明申请
    BIOLOGICAL SUBSTANCE DETECTION METHOD 审中-公开
    生物物质检测方法

    公开(公告)号：US20140220598A1

    公开(公告)日：2014-08-07

    申请号：US14343411

    申请日：2012-09-04

    申请人： Kensaku Takanashi ,  Hisatake Okada ,  Yasushi Nakano ,  Kohsuke Gonda ,  Noriaki Ohuchi ,  Mika Watanabe

    发明人： Kensaku Takanashi ,  Hisatake Okada ,  Yasushi Nakano ,  Kohsuke Gonda ,  Noriaki Ohuchi ,  Mika Watanabe

    IPC分类号： G01N33/58 ,  G01N33/574

    CPC分类号： G01N33/582 ,  G01N21/6428 ,  G01N33/56966 ,  G01N33/57492 ,  G01N2021/6439 ,  G01N2333/70596

    摘要： The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of apart stained for morphological observation when the fluorescent label used for the immunostaining is observed.

    摘要翻译： 本发明提供一种用于特异性检测来自病理标本的生物物质的生物物质检测方法，通过该方法，当使用荧光标记物进行免疫染色并同时进行用于形态学观察的染色剂进行形态学观察的染色时，荧光的结果 即使通过用激发光照射使荧光标记和/或染色剂劣化，也可以适当地评估观察和免疫染色。 根据本发明的生物物质检测方法的特征在于，当使用荧光标记物时，免疫染色部分的亮度保持率相对于形态观察时分离染色的亮度保持率在80％至120％的范围内 观察免疫染色。

    METHOD FOR DETERMINING CANCER ONSET OR CANCER ONSET RISK
    4.
    发明申请
    METHOD FOR DETERMINING CANCER ONSET OR CANCER ONSET RISK 审中-公开
    用于确定癌症或癌症风险的方法

    公开(公告)号：US20130203082A1

    公开(公告)日：2013-08-08

    申请号：US13819008

    申请日：2011-08-26

    申请人： Kohsuke Gonda ,  Minoru Miyashita ,  Motohiro Takeda ,  Noriaki Ohuchi

    发明人： Kohsuke Gonda ,  Minoru Miyashita ,  Motohiro Takeda ,  Noriaki Ohuchi

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6486 ,  B82Y15/00 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/57415 ,  G01N33/588 ,  G01N2800/50

    摘要： A highly accurate and quantitative method for determining cancer onset or cancer onset risk by a quantitative tissue staining method in biological tissues using an antibody capable of recognizing a cancer growth regulatory factor or cancer metastasis regulatory factor such as PAR1 antibody, which inhibits the cancer cell mobility and infiltration is provided. Cancer onset or cancer onset risk is determined using the tissue staining method comprising the steps of: labeling an antibody which recognizes a cancer growth regulatory factor or cancer metastasis regulatory factor with a fluorescent material, and contacting the fluorescent-labeled antibody with a tissue sample; irradiating a tissue site in contact with the antibody with excitation light to acquire a fluorescence image; acquiring an autofluorescence image in a vicinity region of a short wavelength side or long wavelength side of an acquisition region of fluorescence wavelength emitted by the fluorescent material, in the same field of vision and in the same focal point as those of the fluorescence image; acquiring a corrected fluorescence image by image processing to eliminate a fluorescent brightness of the autofluorescence image from the fluorescent brightness of the fluorescence image; counting the number of cells at the tissue site in contact with the antibody; measuring a mean fluorescent brightness of a single fluorescent particle; and calculating the number of fluorescent particles per cell.

    摘要翻译： 使用能够识别癌细胞生长调节因子或癌转移调节因子（例如抑制癌细胞迁移率的PAR1抗体）的抗体，通过定量组织染色法在生物组织中测定癌症发病或癌症发病风险的高度准确和定量的方法 并提供渗透。 使用组织染色方法确定癌症发病或癌症发病风险，其包括以下步骤：用荧光材料标记识别癌症生长调节因子或癌症转移调节因子的抗体，并将荧光标记的抗体与组织样品接触; 用激发光照射与抗体接触的组织部位以获得荧光图像; 在荧光材料发射的荧光波长的获取区域的短波长侧或长波长侧的附近区域中，在与荧光图像相同的视场和相同的焦点中获取自发荧光图像; 通过图像处理获得校正的荧光图像，以从荧光图像的荧光亮度消除自发荧光图像的荧光亮度; 计数与抗体接触的组织部位的细胞数; 测量单个荧光颗粒的平均荧光亮度; 并计算每个细胞的荧光颗粒数。

    METHOD FOR STAINING TISSUE
    6.
    发明申请
    METHOD FOR STAINING TISSUE 审中-公开
    用于染色组织的方法

    公开(公告)号：US20140212889A1

    公开(公告)日：2014-07-31

    申请号：US14342829

    申请日：2012-09-04

    申请人： Hideki Gouda ,  Hisatake Okada ,  Yasushi Nakano ,  Kohsuke Gonda ,  Noriaki Ohuchi ,  Mika Watanabe

    发明人： Hideki Gouda ,  Hisatake Okada ,  Yasushi Nakano ,  Kohsuke Gonda ,  Noriaki Ohuchi ,  Mika Watanabe

    IPC分类号： G01N33/569

    CPC分类号： G01N33/569 ,  G01N1/30

    摘要： It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.

    摘要翻译： 本发明的目的是提供一种组织染色方法，其可以在单个部分和单个部分上观察关于组织形态的信息和关于待检测的抗原分子的生物物质的信息 查看字段。 本发明提供一种组织染色方法，包括在单个组织切片上连续进行（A）HE（苏木精 - 伊红）染色和（B）组织化学染色，其中组织化学染色定义为组织化学技术 通过使用要检测的生物物质和能够特异性结合待检测的生物物质的探针生物物质之间的结合反应，以可见的方式检测待检测的生物物质。

    BIOLOGICAL SUBSTANCE DETECTION METHOD
    7.
    发明申请
    BIOLOGICAL SUBSTANCE DETECTION METHOD 有权
    生物物质检测方法

    公开(公告)号：US20130157287A1

    公开(公告)日：2013-06-20

    申请号：US13819453

    申请日：2011-08-30

    申请人： Kensaku Takanashi ,  Hideki Gouda ,  Hisatake Okada ,  Yasushi Nakano ,  Kohsuke Gonda ,  Motohiro Takeda ,  Noriaki Ohuchi

    发明人： Kensaku Takanashi ,  Hideki Gouda ,  Hisatake Okada ,  Yasushi Nakano ,  Kohsuke Gonda ,  Motohiro Takeda ,  Noriaki Ohuchi

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6486 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2021/6441

    摘要： A biological substance detection method for detecting a biological substance specifically in a pathological specimen, comprising a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen, with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label.

    摘要翻译： 一种用于特异性检测病理标本中生物物质的生物物质检测方法，包括使用荧光标记对病理标本进行免疫染色的步骤，用形态学观察目的的染色试剂（曙红）染色病理标本的步骤，以观察 病理标本的形态，用激发光照射染色的病理标本的步骤，引起荧光发射并检测病理标本中的生物物质。 在免疫染色病理标本的步骤中，使用在与曙红的激发波长区域不同的区域中出现激发波长的特殊荧光粒子作为荧光标记。