Single-Walled Carbon Nanotube Biosensor for Detection of Glucose, Lactate, and Urea
    2.
    发明申请
    Single-Walled Carbon Nanotube Biosensor for Detection of Glucose, Lactate, and Urea 审中-公开
    用于检测葡萄糖,乳酸和尿素的单壁碳纳米管生物传感器

    公开(公告)号:US20160178567A1

    公开(公告)日:2016-06-23

    申请号:US14910294

    申请日:2014-08-05

    摘要: A single-walled carbon nanotube-based micron scale multiplex biosensor is provided that enables the detection of glucose, lactate, and urea. The sensor is based on modification of semiconducting single-walled carbon nanotubes using a linker that non-covalently associates with the nanotubes and covalently couples to an enzyme. Reaction of a physiological substrate with the enzyme results in increased resistance of the nanotubes within the sensor. The sensor is suitable for use in patient monitoring, particularly in a clinical setting. Incorporation of read out electronics and an RF signal generator into the sensor device enables it to communicate to a relay station or remote receiver. Methods are also provided for fabricating the biosensor device and using the device for detection.

    摘要翻译: 提供了一种能够检测葡萄糖,乳酸和尿素的单壁碳纳米管微米级多重生物传感器。 该传感器基于使用与纳米管非共价缔合并共价连接到酶的接头的半导体单壁碳纳米管的修饰。 生理底物与酶的反应导致传感器内纳米管的电阻增加。 该传感器适用于患者监测,特别是在临床环境中。 将读出的电子装置和RF信号发生器结合到传感器装置中,使其能够与中继站或远程接收器通信。 还提供了用于制造生物传感器装置并使用该装置进行检测的方法。

    Metalenses for Use in Night-Vision Technology

    公开(公告)号:US20220228918A1

    公开(公告)日:2022-07-21

    申请号:US17581186

    申请日:2022-01-21

    IPC分类号: G01J5/0806 G02B1/00 G01J5/08

    摘要: Thin film infrared (IR) imaging devices including a metalens layer configured to focus IR radiation onto a plasmonic absorber layer are provided for thin form factor and lightweight design of IR imaging devices. The devices can be produced using directed assembly methods and transfer printing of nanoelements. The fabrication methods are scalable and provide low cost means to produce the IR imaging devices.

    POINT-OF-CARE IMMUNOSENSING DEVICE FOR MULTI-BIOMARKER DETECTION
    10.
    发明申请
    POINT-OF-CARE IMMUNOSENSING DEVICE FOR MULTI-BIOMARKER DETECTION 审中-公开
    用于多生物标记检测的点保护免疫设备

    公开(公告)号:US20160258945A1

    公开(公告)日:2016-09-08

    申请号:US15027466

    申请日:2014-10-21

    摘要: An immunosensing device includes a hub mountable to a device for fluid collection, such as a syringe, sample collection container, or vacuum collection container, and a biosensor mounted to the hub. The biosensor includes a biosensor active area in fluid communication with a fluid passage within the hub. The biosensor active area includes nanoelements functionalized with one or more antibodies or antigen binding fragments thereof for contact with a fluid in the fluid passage. The biosensor active area can include multiple regions each including nanoelements functionalized with a different antibody or antigen binding fragment thereof to detect multiple biomarkers. The biosensor, separately or attached to the hub, can be inserted in a biomarker reader for detection of a biomarker in the fluid.

    摘要翻译: 免疫感测装置包括可安装到用于流体收集的装置的毂,例如注射器,样品收集容器或真空收集容器以及安装到毂的生物传感器。 生物传感器包括与轮毂内的流体通道流体连通的生物传感器有效区域。 生物传感器活性区域包括用一种或多种抗体或其抗原结合片段官能化的纳米元件,用于与流体通道中的流体接触。 生物传感器活性区域可以包括多个区域,每个区域包括用不同抗体或其抗原结合片段功能化的纳米元件,以检测多个生物标志物。 单独或附接到轮毂的生物传感器可以插入生物标志物读数器中,以检测流体中的生物标志物。