公开(公告)号：US20150346474A1

公开(公告)日：2015-12-03

申请号：US14727337

申请日：2015-06-01

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI

IPC分类号： G02B21/00

CPC分类号： G01N21/6458 ,  G01N2201/023 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0076

摘要： An illumination apparatus used for fluorescence observation of a sample containing a fluorescent material by a microscope apparatus, comprising an excitation light emission unit that emits excitation light for exciting the fluorescent material contained in the sample. The excitation light emission unit illuminates at least a bleaching reduction illumination region around an observed region in which the sample is present.

摘要翻译： 一种用于通过显微镜装置对包含荧光材料的样品进行荧光观察的照明装置，包括：激发光发射单元，其发射用于激发包含在样品中的荧光材料的激发光。 激发光发射单元至少照射存在样品的观察区域周围的漂白还原照射区域。

公开(公告)号：US20240192479A1

公开(公告)日：2024-06-13

申请号：US18438521

申请日：2024-02-12

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI

IPC分类号： G02B23/24 ,  G02B5/30 ,  G02B27/28 ,  H04N23/50

CPC分类号： G02B23/243 ,  G02B5/3083 ,  G02B27/283 ,  H04N23/555

摘要： An objective optical system comprising a lens group that forms an object image, a polarizing beam splitter having an optical path dividing surface that divides an optical path into a first optical path that intersects the optical axis of the lens group and a second optical path that extends straight on the optical axis, a first reflection surface provided in the first optical path, a second reflection surface provided in the second optical path, and a quarter wave plate provided between the polarizing beam splitter and the first reflection surface. The objective optical system satisfies the following conditional expression (1):


(Tp+Ts)/(100−Ts)≥1.25  (1)

where Tp (%) is the transmittance of the optical path dividing surface for p-polarized light, and Ts (%) is the transmittance of the optical path dividing surface for s-polarized light.

公开(公告)号：US20160306154A1

公开(公告)日：2016-10-20

申请号：US15094847

申请日：2016-04-08

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI ,  Yu KIKUCHI

IPC分类号： G02B21/06 ,  G02B21/16 ,  G02B3/06 ,  G02B21/00 ,  G02B3/00

CPC分类号： G02B21/06 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/367

摘要： A light sheet illumination microscope includes an illumination optical system configured to illuminate a sample from a direction substantially perpendicular to an optical axis of a detection optical system. The illumination optical system includes a first optical element configured to convert light emitted from a light source into a light sheet that forms an illumination area having a sheet shape substantially perpendicular to the optical axis of the detection optical system when the sample is irradiated with the light sheet. The illumination optical system further includes a second optical element that configured to act on the light emitted from the light source such that the light sheet is converged, diverged or diffracted in a width direction of the light sheet.

摘要翻译： 照明照明显微镜包括照明光学系统，其配置为从基本上垂直于检测光学系统的光轴的方向照射样品。 照明光学系统包括：第一光学元件，被配置为将光源发射的光转换成光片，所述光片形成具有基本垂直于检测光学系统的光轴的片状的照明区域， 片。 照明光学系统还包括第二光学元件，其被配置为作用于从光源发射的光，使得光片在光片的宽度方向上会聚，发散或衍射。

公开(公告)号：US20210311368A1

公开(公告)日：2021-10-07

申请号：US17211143

申请日：2021-03-24

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI

IPC分类号： G02F1/29

摘要： An optical scanning apparatus includes a light source; an optical fiber; a wavefront modulator configured to emit light, a reference wavefront of which is corrected, based on information about the reference wavefront and correction information and make the light incident upon the first end face via a predetermined optical system; and a processor configured to control the wavefront modulator based on the correction information and the information about the reference wavefront, the correction information being found based on a correlation between a first distribution and a second distribution, the first distribution being at least one of an intensity distribution or a phase distribution of emergent light from the second end face, the second distribution being at least one of an intensity distribution or a phase distribution of the desired light.

公开(公告)号：US20210207071A1

公开(公告)日：2021-07-08

申请号：US17209846

申请日：2021-03-23

申请人： OLYMPUS CORPORATION

发明人： Koh MOHRI ,  Shintaro TAKAHASHI ,  Asuka NAKAMURA ,  Shoichi KANEKO ,  Yoshihito IGUCHI ,  Shogo USUI ,  Takayuki NAKATOMI

IPC分类号： C12M1/34 ,  C12M1/36

摘要： A cell culturing device includes: a sensor that measures a pH of a medium in which cells are being cultured; and one or more processors including hardware. The one or more processors are configured to: measure an elapsed time since the cells were seeded in the medium; determine whether the measured pH is lower than a prescribed threshold and whether the measured elapsed time has passed a prescribed time; and issue an instruction for medium replacement in response to determining that the pH is lower than the prescribed threshold or in response to determining that the elapsed time has passed the prescribed time.

公开(公告)号：US20170139193A1

公开(公告)日：2017-05-18

申请号：US15348642

申请日：2016-11-10

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI

IPC分类号： G02B21/00 ,  G02B5/00 ,  G02B15/00

CPC分类号： G02B21/006 ,  G02B5/005 ,  G02B15/00 ,  G02B21/0032 ,  G02B21/10 ,  G02B21/367

摘要： A light sheet microscope includes an illumination optical system that irradiates a light sheet onto a sample and a setting changer that changes a setting of a divergence angle or convergence angle relating to a width direction of the light sheet emitted from the illumination optical system.

公开(公告)号：US20200141768A1

公开(公告)日：2020-05-07

申请号：US16735332

申请日：2020-01-06

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI

IPC分类号： G01D5/353 ,  G01B11/24

摘要： A bending measurement apparatus includes a first multimode fiber, a wavefront input apparatus, a first wavefront measurement device, and a processor. The wavefront input apparatus inputs a first wavefront to the first multimode fiber as an input wavefront. The first wavefront measurement device measures an output wavefront outputted from the first multimode fiber as a measured wavefront. The processor select correspondence information which corresponds to the measured wavefront. The correspondence information shows a correspondence relationship between the input wavefront and the output wavefront. The processor sets the bending amount corresponding to the selected correspondence information as a current bending amount of the first multimode fiber.

公开(公告)号：US20170322408A1

公开(公告)日：2017-11-09

申请号：US15495294

申请日：2017-04-24

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI

IPC分类号： G02B21/36 ,  G06K9/46 ,  G02B21/16 ,  G02B21/06 ,  G06K9/62 ,  G02B21/00

CPC分类号： G02B21/365 ,  G02B21/002 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/06 ,  G02B21/16 ,  G02B21/367 ,  G06K9/2027 ,  G06K9/4661 ,  G06K9/6202

摘要： An illumination setting method includes acquiring an image of a sample onto which a light sheet has been radiated; determining, on the basis of the acquired image of the sample, a subordinate ray angle with respect to a width direction of the light sheet; and performing a setting of the illumination optical system according to the determined subordinate ray angle.

公开(公告)号：US20170160198A1

公开(公告)日：2017-06-08

申请号：US15431245

申请日：2017-02-13

申请人： OLYMPUS CORPORATION

发明人： Yoshihito IGUCHI

IPC分类号： G01N21/64 ,  G02B21/00

CPC分类号： G01N21/6458 ,  G01N2201/023 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0076

摘要： A microscopy observation method for fluorescence observation of a sample including an object to be observed containing a fluorescent material using a microscope apparatus, including an excitation light emission step of emitting excitation light for exciting the fluorescent material contained in the sample; and an oxygen concentration reduction step of reducing the oxygen concentration at least in an observed region in which the sample is present.