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公开(公告)号：US20180329193A1
公开(公告)日：2018-11-15
申请号：US16003402
申请日：2018-06-08
Applicant: OLYMPUS CORPORATION
Inventor： Tadashi HIRATA , Shintaro TAKAHASHI
CPC classification number: G02B21/086 , G02B21/06 , G02B21/14 , G02B21/26
Abstract: An observation device including: a stage having a transparent pedestal surface; an illumination system under the pedestal surface, the illumination system emitting illumination light toward the pedestal surface; and an object system under the pedestal surface for capturing transmission light generated from the illumination light, reflected off a reflection surface and transmitted through a sample. Wherein a first light path in the illumination system is different from a second light path in the object system, in a first pupil surface of the illumination system, the illumination system generates the illumination light by restricting light in a first transparent region, in a second pupil surface of the object system, the object system restricts the transmission light in a second transparent region, and the second transparent region has first and second subregions with different transmittance, the second subregion located between the first subregion and an edge of the second transparent region.
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公开(公告)号：US20170010453A1
公开(公告)日：2017-01-12
申请号：US15275359
申请日：2016-09-24
Applicant: OLYMPUS CORPORATION
Inventor： Kentaro IMOTO , Shinichi TAKIMOTO , Shintaro TAKAHASHI , Atsushi DOI
CPC classification number: G02B21/0076 , G01N21/6458 , G01N2201/06113 , G01N2201/1053 , G01N2201/12 , G02B21/0032 , G02B21/006 , G02B21/0068 , G02B21/008 , G02B21/0084
Abstract: Provided is a microscope provided with: a scanner that scans an excitation beam coming from a light source; an objective optical system that focuses the scanned excitation beam onto a sample and that collects fluorescence generated at individual scanning positions in the sample; a detector that detects the collected fluorescence; a light blocking member that is disposed between the detector and the system and that partially blocks the collected fluorescence; a switching portion that switches the positional relationship between the member and a light-focusing point of the excitation beam in the sample between an optically conjugate positional relationship, in which an in-focus fluorescence generated at the light-focusing point passes through the member, and a non-conjugate positional relationship, in which the in-focus fluorescence is blocked by the member; and a computing portion that computes a difference between fluorescence signals acquired by the detector in the two positional relationships.
Abstract translation: 提供了一种显微镜，其具有：扫描来自光源的激发光束的扫描仪; 物镜光学系统，其将扫描的激发光束聚焦到样品上并且收集样品中各个扫描位置产生的荧光; 检测所收集的荧光的检测器; 光阻挡构件，其设置在所述检测器和所述系统之间并部分阻挡所述收集的荧光; 切换部，其以在所述光聚合点处产生的聚焦荧光透过所述构件的光学共轭位置关系之间切换所述构件与所述样品中的所述激发光束的聚光点之间的位置关系， 以及非共轭位置关系，其中聚焦荧光被构件阻挡; 以及计算部分，其计算由两个位置关系中的检测器获取的荧光信号之间的差异。
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公开(公告)号：US20130301096A1
公开(公告)日：2013-11-14
申请号：US13939286
申请日：2013-07-11
Applicant: OLYMPUS CORPORATION
Inventor： Shintaro TAKAHASHI
IPC: G02B26/10
CPC classification number: G02B26/105 , G01B11/24
Abstract: A scanning rate is increased without causing the light utilization efficiency to decrease. An optical scanning device includes a polarization switching unit that switches the polarization direction of a beam at a predetermined switching timing; at least one polarization beam splitter that splits the beam into two optical paths in accordance with the polarization direction switched by the polarization switching unit; a reflecting optical system that causes the beams split by the polarization beam splitter to have relative angles in the same plane so as to make the beams meet at the same location; and a scanner that scans the beams made to meet at the same location by means of the reflecting optical system in a direction parallel to the plane in synchronization with the switching timing of the polarization switching unit.
Abstract translation: 增加扫描速率，而不会降低光利用效率。 光学扫描装置包括在预定的切换定时切换光束的偏振方向的偏振切换单元; 至少一个偏振分束器，其根据由偏振切换单元切换的偏振方向将光束分成两个光路; 反射光学系统，其使得由偏振分束器分束的光束在相同平面中具有相对角度，以使得光束在相同位置处相遇; 以及扫描器，其与所述偏振切换单元的切换定时同步地扫描通过所述反射光学系统在与所述平面平行的方向上在相同位置处相交的光束。
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公开(公告)号：US20190390151A1
公开(公告)日：2019-12-26
申请号：US16561128
申请日：2019-09-05
Applicant: OLYMPUS CORPORATION
Inventor： Shintaro TAKAHASHI , Koh MOHRI , Tsuyoshi MOCHIZUKI , Asuka NAKAMURA , Shoichi KANEKO , Shogo USUI , Ikutoshi FUKUSHIMA , Masaru MIZUNAKA
Abstract: A medium changing device includes a lid disposed at a position where two or more regions in which a medium may be stored are covered therewith, the regions being disposed adjacent to each other and being open upward; one or more flow-path members each disposed so as to penetrate the lid, and each disposed at a position where one of the regions is bridged to another therewith when the lid is disposed at the position where the regions are covered; and a pump disposed on the other side of the lid and acting on the intermediate sections of the flow-path members, exposed on the other side, so as to cause the medium to flow from the opening at one end toward the opening at the other end of each of the flow-path members.
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公开(公告)号：US20190219810A1
公开(公告)日：2019-07-18
申请号：US16364946
申请日：2019-03-26
Applicant: OLYMPUS CORPORATION
Inventor： Masaru MIZUNAKA , Shintaro TAKAHASHI , Akira MATSUSHITA , Yohei TANIKAWA , Tsuyoshi MOCHIZUKI , Shinichi TAKIMOTO
CPC classification number: G02B21/16 , G01N21/17 , G01N21/64 , G01N21/6458 , G01N2021/6478 , G02B21/02 , G02B21/06 , G02B21/10 , G02B21/12 , G02B21/125 , G02B21/24 , G02B21/33 , G02B21/36 , G02B21/367
Abstract: An observation apparatus including: a light-source that emits illumination light and excitation light upward from below a specimen; and an image-capturing optical system having an objective lens that focuses, below the specimen, transmitted light, which is the illumination light that is emitted from the light-source, that is reflected above the specimen, and that has passed through the specimen, and fluorescence that is generated in the specimen that has been irradiated with the excitation light emitted from the light-source, wherein the light-source is disposed radially outside the objective lens.
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Patent Agency Ranking
公开(公告)号：US20150028193A1
公开(公告)日：2015-01-29
申请号：US14458474
申请日：2014-08-13
Applicant: OLYMPUS CORPORATION
Inventor： Ken FUJINUMA , Shintaro TAKAHASHI
CPC classification number: G01N21/17 , G01J1/44 , G01J2001/4242 , G01N2201/06113 , G01N2201/0697 , G02B21/002 , G02B21/0084 , G02B21/16 , G02B23/24
Abstract: A laser scanning type observation apparatus includes a pulsed-laser oscillation means irradiating pulsed laser to an object, a detector receiving light from the object to output a detection signal, a means detecting pulsed-laser oscillation to output a synchronous signal, a circuit delaying the synchronous signal for an optional amount of time to output a trigger signal, a means sampling the detection signal in synchronization with the trigger signal, a memory storing the sampled detection signal, a setting unit capable of setting delay time for delaying the synchronous signal in two or more stages within one period of the synchronous signal, and a decision unit determining an optimum delay stage for image formation using data on intensities of the detection signal at the respective delay stages, wherein the setting means fixes delay time for delaying the synchronous signal at delay time corresponding to the delay stage determined by the decision unit.
Abstract translation: 激光扫描型观察装置包括将物体照射脉冲激光的脉冲激光振荡装置，从物体接收光以输出检测信号的检测器，检测脉冲激光振荡以输出同步信号的装置，延迟电路 同步信号，用于输出触发信号的可选择的时间量，与触发信号同步地对检测信号进行采样的装置;存储采样检测信号的存储器;能够设置用于延迟同步信号的延迟时间的设置单元 或同步信号的一个周期内的多个阶段，以及判定单元，使用关于各个延迟级的检测信号的强度的数据，确定用于图像形成的最佳延迟级，其中，所述设定单元固定用于将同步信号延迟的延迟时间 延迟时间对应于由判定单元确定的延迟级。
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公开(公告)号：US20190219809A1
公开(公告)日：2019-07-18
申请号：US16366682
申请日：2019-03-27
Applicant: OLYMPUS CORPORATION
Inventor： Tsuyoshi MOCHIZUKI , Shintaro TAKAHASHI , Akira MATSUSHITA , Yohei TANIKAWA , Masaru MIZUNAKA , Shinichi TAKIMOTO
CPC classification number: G02B21/086 , C12M1/34 , G01N21/01 , G01N21/17 , G01N21/59 , G01N2201/062 , G02B21/088 , G02B21/26 , G02B21/33 , G02B21/34 , G02B21/36
Abstract: An observation apparatus including: a top plate on which a container in which a specimen is accommodated can be placed, and through which illumination light can pass; a light source that emits the illumination light upward from below the specimen; an objective lens that focuses, below the specimen and the top plate, transmitted light which is the illumination light that has passed through the specimen from thereabove and that has passed through the top plate; and a camera that captures the transmitted light, wherein the light source emits the illumination light toward an area above the specimen from outside the objective lens in a radial direction, and the top plate is provided with a mark that specifies a viewing-field area of the camera.
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公开(公告)号：US20190113459A1
公开(公告)日：2019-04-18
申请号：US16215809
申请日：2018-12-11
Applicant: OLYMPUS CORPORATION
Inventor： Asuka SUEKANE , Shintaro TAKAHASHI , Kentaro IMOTO , Atsushi DOI , Shinichi TAKIMOTO
IPC: G01N21/64
CPC classification number: G01N21/6458 , G01N21/6428 , G01N35/00 , G01N35/00722 , G01N2035/00891 , G01N2201/12
Abstract: An observation assistance device of the present invention includes: an information storage unit that stores sample state information showing a sample state change, a type of sample, a type of fluorescent substance, and an observation condition in fluorescence observation performed on a predetermined sample, and under a predetermined observation condition; an input unit via which inputs the type of sample to be observed and the type of fluorescent substance to be used; an assistance-display generating unit that reads sample state information and an observation condition of fluorescence observation performed on the same type of sample as the type of sample input, using the same type of fluorescent substance as the type of fluorescent substance, and generates an assistance display showing the sample state information in relation to the two or more parameters included in the observation condition; and a display unit that displays the generated assistance display.
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公开(公告)号：US20180008152A1
公开(公告)日：2018-01-11
申请号：US15709652
申请日：2017-09-20
Applicant: OLYMPUS CORPORATION
Inventor： Takeshi WATANABE , Shintaro TAKAHASHI
CPC classification number: A61B5/026 , A61B5/0261 , A61B5/0285 , A61B8/06 , A61B10/00 , G01S15/8979
Abstract: A blood-vessel recognition blood-flow measurement method including: obtaining a real-time Doppler spectrum by performing a Fourier transform on a temporal waveform of the intensity of scattered light of laser light in a living body; calculating a normalized real-time Doppler spectrum and a normalized zero spectrum; calculating a region spectrum from a subtracted spectrum that is calculated through subtraction of these calculated spectra; calculating a PS reference spectrum by subtracting, from the region spectrum, the maximum value of the region spectrum in a predetermined PS reference region; calculating an average frequency on the basis of a computational spectrum that is obtained by replacing an element of which the PS reference spectrum is negative with zero; and determining a blood flow velocity by comparing the calculated average frequency with a predetermined threshold.
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公开(公告)号：US20170261732A1
公开(公告)日：2017-09-14
申请号：US15607666
申请日：2017-05-29
Applicant: OLYMPUS CORPORATION
Inventor： Shintaro TAKAHASHI , Tadashi HIRATA , Yasunobu IGA , Shinichi TAKIMOTO , Takashi MIYOSHI
CPC classification number: G02B21/06 , C12M1/34 , G02B21/084 , G02B21/14 , G02B21/24 , G02B21/361
Abstract: Provided is an observation apparatus and an observation method with which it is possible to observe imaging subjects, such as cells or the like, without labeling the imaging subjects and without causing an increase in the apparatus size. Provided is an observation apparatus including: a light-source unit that emits illumination light upward from below a sample; and an image-capturing optical system that has an objective lens that collects transmitted light, which is the illumination light emitted from the light-source unit that has passed through the sample by being reflected above the sample and that captures, below the sample, the transmitted light collected by the objective lens.
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