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    Cartridge for digital real-time PCR
    1.
    发明授权
    Cartridge for digital real-time PCR 有权

    公开(公告)号：US11426731B2

    公开(公告)日：2022-08-30

    申请号：US16390380

    申请日：2019-04-22

    Applicant: OPTOLANE Technologies Inc.

    Inventor： Sergiy Oleksandrov ,  Do Young Lee ,  Min Sik Song ,  Kyung Hak Choi

    IPC: B01L3/00 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: A cartridge for digital real-time Polymerase chain reaction (PCR) includes a microfluidic chamber, a well array, a CMOS photo sensor array and a PCB. The microfluidic chamber includes an inlet formed for injection of a liquid sample, the microfluidic chamber being capable of injection molding. The well array includes a plurality of microwells through which upper and lower portions are perforated and being attached to a lower surface of the microfluidic chamber. The CMOS photo sensor array is disposed below the well array to capture a response image of a sample filled in microwells of the well array. The PCB has a vent formed for vacuum processing of micro flow path formed in the microfluidic chamber, a space formed between the well array and the microfluidic chamber, and a microwell formed in the well array as the liquid sample is injected through the inlet.

    Biochip including side emitting-type light-emitting device and fabrication method thereof
    5.
    发明授权
    Biochip including side emitting-type light-emitting device and fabrication method thereof 有权

    公开(公告)号：US10018562B2

    公开(公告)日：2018-07-10

    申请号：US14824764

    申请日：2015-08-12

    Applicant: OPTOLANE TECHNOLOGIES INC.

    Inventor： Do Young Lee ,  In Gyun Jeon

    IPC: G01N21/64 ,  H01L31/18 ,  H01L31/12

    CPC classification number: G01N21/6428 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N2201/062 ,  H01L31/125 ,  H01L31/18

    Abstract: The present disclosure a biochip including a side emitting-type light-emitting device, in which the bio-chip includes: a light-emitting device for emitting light from a fluorescent material; reflective layers provided over and under the light-emitting device so as to emit light from the sides of the light-emitting device; and reaction regions formed by etching of flanking regions of the light-emitting device. In the biochip, light emitted from the sides of the light-emitting device causes a biochemical reaction in the reaction regions. According to the present disclosure, light emitted from the light-emitting device moves only laterally without being transferred to the top or bottom of the bio-layer, and is transferred to the reaction regions formed by etching of flanking regions of the light-emitting device, so that a biochemical reaction in the reaction regions can be more efficiently performed.

    Immunoassay cartridge
    8.
    发明授权
    Immunoassay cartridge 有权

    公开(公告)号：US11162941B2

    公开(公告)日：2021-11-02

    申请号：US15881986

    申请日：2018-01-29

    Applicant: OPTOLANE Technologies Inc.

    Inventor： Do Young Lee ,  Kyung Hak Choi

    IPC: G01N33/543 ,  B01L3/00 ,  G01N21/64 ,  G02B5/22 ,  G01N21/76 ,  G01N21/03

    Abstract: An immunoassay cartridge is disclosed that can enhance the reliability of an antigen-antibody reaction while increasing a speed of an antigen-antibody reaction. An immunoassay cartridge includes a reaction chamber and a fluorescence sensor assembly. A plurality of antibodies or antigens is attached to an inner surface including a bottom surface of the reaction chamber closest to the sensor. The fluorescence sensor assembly is disposed on a bottom surface of the reaction chamber. Since the bottom surface of the reaction chamber and the upper surface of the fluorescence sensor assembly are arranged to coincide with each other, even if fluid is repeatedly moved in a first direction after the fluid moves in a second direction in the reaction chamber and then moved in the first direction, there is no obstacle in the movement of the fluid. Thus, it is possible to increase the probability of antigen-antibody reaction in the reaction chamber.

    Biochip including side emitting-type light-emitting device and fabrication method thereof
    9.
    发明授权
    Biochip including side emitting-type light-emitting device and fabrication method thereof 有权

    公开(公告)号：US10591415B2

    公开(公告)日：2020-03-17

    申请号：US16001056

    申请日：2018-06-06

    Applicant: OPTOLANE TECHNOLOGIES INC.

    Inventor： Do Young Lee ,  In Gyun Jeon

    IPC: G01N21/64 ,  H01L31/12 ,  H01L31/18

    Abstract: The present disclosure a biochip including a side emitting-type light-emitting device, in which the bio-chip includes: a light-emitting device for emitting light from a fluorescent material; reflective layers provided over and under the light-emitting device so as to emit light from the sides of the light-emitting device; and reaction regions formed by etching of flanking regions of the light-emitting device. In the biochip, light emitted from the sides of the light-emitting device causes a biochemical reaction in the reaction regions. According to the present disclosure, light emitted from the light-emitting device moves only laterally without being transferred to the top or bottom of the bio-layer, and is transferred to the reaction regions formed by etching of flanking regions of the light-emitting device, so that a biochemical reaction in the reaction regions can be more efficiently performed.

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