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公开(公告)号：US20100021437A1
公开(公告)日：2010-01-28
申请号：US12419222
申请日：2009-04-06
申请人： Ole Isacson , Jan Pruszak , Marius Wernig , Rudolf Jaenisch
发明人： Ole Isacson , Jan Pruszak , Marius Wernig , Rudolf Jaenisch
IPC分类号： A61K35/12 , C12N5/00 , C12N5/0797 , A61P25/00 , A61P25/16
CPC分类号： A61K35/30 , A61K35/12 , C12N5/0618 , C12N2500/25 , C12N2500/46 , C12N2501/115 , C12N2501/119 , C12N2501/41 , C12N2506/45 , C12N2533/52
摘要： The present invention provides novel populations of neural stem cells derived from induced pluripotent stem cells, and methods for making and using the same.
摘要翻译： 本发明提供了源自诱导多能干细胞的新型神经干细胞群体及其制备和使用方法。
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公开(公告)号：US09382515B2
公开(公告)日：2016-07-05
申请号：US12595041
申请日：2008-04-07
申请人： Rudolf Jaenisch , Yaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
发明人： Rudolf Jaenisch , Yaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
IPC分类号： C12N5/00 , C12N5/074 , C07K14/47 , A01K67/027 , C12N15/85 , C12N15/877 , G01N33/50
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/11 , C12N2506/13 , C12N2800/30 , C12N2830/003 , C12N2830/006 , G01N33/5023 , G01N2333/91011
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译： 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。 在另外的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞，所述细胞的用途以及用于鉴定用于重编程体细胞的药剂的方法。
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公开(公告)号：US20110076678A1
公开(公告)日：2011-03-31
申请号：US12595041
申请日：2008-04-07
申请人： Rudolf Jaenisch , Jaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
发明人： Rudolf Jaenisch , Jaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/11 , C12N2506/13 , C12N2800/30 , C12N2830/003 , C12N2830/006 , G01N33/5023 , G01N2333/91011
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译： 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。 在另外的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞，所述细胞的用途以及用于鉴定用于重编程体细胞的药剂的方法。
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公开(公告)号：US20130022583A1
公开(公告)日：2013-01-24
申请号：US13522002
申请日：2011-01-19
IPC分类号： C12N5/0797 , C12N5/079 , C12Q1/04 , G01N33/566 , A61P37/00 , C12Q1/68 , A61K35/30 , A61P25/00 , A61P25/28 , A61P25/18 , C12N5/0793 , G01N33/573
CPC分类号： C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N2501/60 , C12N2506/02 , C12N2506/1307 , C12N2506/14 , C12N2506/45 , C12N2510/00 , G01N33/5058
摘要： Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.
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公开(公告)号：US09057053B2
公开(公告)日：2015-06-16
申请号：US13522002
申请日：2011-01-19
IPC分类号： C12N5/0797 , C12N5/071 , C12Q1/68 , G01N33/536 , C12N5/0793 , C12N5/079 , G01N33/50
CPC分类号： C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N2501/60 , C12N2506/02 , C12N2506/1307 , C12N2506/14 , C12N2506/45 , C12N2510/00 , G01N33/5058
摘要： Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.
摘要翻译： 提供了用于产生功能性神经元，星形星，少突胶质细胞和祖细胞的方法，组合物和试剂盒。 这些方法，组合物和试剂盒可用于产生用于移植的神经元，星形胶质细胞，少突胶质细胞和祖细胞，用于实验评估，作为谱系和细胞特异性产物的来源等，例如用于治疗人 中枢神经系统疾病 还提供了用于筛选候选试剂以将细胞转化成神经元细胞，星形胶质细胞，少突胶质细胞和祖细胞的活性的方法，组合物和试剂盒。
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