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公开(公告)号：US07868205B2
公开(公告)日：2011-01-11
申请号：US10574088
申请日：2004-09-24
申请人： Oscar Moradei , Isabelle Paquin , Silvana Leit , Sylvie Frechette , Arkadii Vaisburg , Jeffrey M. Besterman , Pierre Tessier , Tammy C. Mallais
发明人： Oscar Moradei , Isabelle Paquin , Silvana Leit , Sylvie Frechette , Arkadii Vaisburg , Jeffrey M. Besterman , Pierre Tessier , Tammy C. Mallais
IPC分类号： C07C233/65 , A61K31/165
CPC分类号： C07D307/84 , C07C233/25 , C07C235/58 , C07C237/20 , C07C237/40 , C07C255/60 , C07C323/42 , C07D207/325 , C07D207/327 , C07D207/335 , C07D209/08 , C07D213/73 , C07D233/54 , C07D233/84 , C07D249/06 , C07D257/04 , C07D263/57 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D307/52 , C07D307/54 , C07D319/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/36 , C07D333/58 , C07D333/60 , C07D333/70 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07F7/1804
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：US20080132459A1
公开(公告)日：2008-06-05
申请号：US10574088
申请日：2004-09-24
申请人： Oscar Moradei , Isabelle Paquin , Silvana Leit , Sylvie Frechette , Arkadii Vaisburg , Jeffrey M. Besterman , Pierre Tessier , Tammy C. Mallais
发明人： Oscar Moradei , Isabelle Paquin , Silvana Leit , Sylvie Frechette , Arkadii Vaisburg , Jeffrey M. Besterman , Pierre Tessier , Tammy C. Mallais
IPC分类号： A61K31/16 , A61K31/165 , A61K31/381 , A61K31/4162 , A61K31/70 , A61P31/10 , A61P33/02 , A61P35/00 , A61P35/02 , C07C233/00 , C07C233/80 , C07D235/02 , C07D333/04 , C07D403/00 , C07D403/04 , C07D409/04 , C07D409/08 , C12N9/99
CPC分类号： C07D307/84 , C07C233/25 , C07C235/58 , C07C237/20 , C07C237/40 , C07C255/60 , C07C323/42 , C07D207/325 , C07D207/327 , C07D207/335 , C07D209/08 , C07D213/73 , C07D233/54 , C07D233/84 , C07D249/06 , C07D257/04 , C07D263/57 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D307/52 , C07D307/54 , C07D319/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/36 , C07D333/58 , C07D333/60 , C07D333/70 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07F7/1804
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶。 本发明提供了抑制组蛋白脱乙酰酶酶活性的化合物和方法。 本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
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公开(公告)号：US08598168B2
公开(公告)日：2013-12-03
申请号：US11696880
申请日：2007-04-05
申请人： Oscar Moradei , Isabelle Paquin , Sylvie Frechette , Tammy Mallais , Simon Roy , Roger Machaalani , Arkadii Vaisburg , Jeffrey M Besterman , Pierre Tessier , David Smil , Silvana Leit , Robert Déziel
发明人： Oscar Moradei , Isabelle Paquin , Sylvie Frechette , Tammy Mallais , Simon Roy , Roger Machaalani , Arkadii Vaisburg , Jeffrey M Besterman , Pierre Tessier , David Smil , Silvana Leit , Robert Déziel
IPC分类号： A61K31/535 , A61K31/445 , A61K31/44 , A61K31/42 , A61K31/415 , A61K31/40 , A61K31/28
CPC分类号： C07D333/36 , C07C235/56 , C07C237/40 , C07C271/28 , C07D207/12 , C07D207/14 , C07D207/325 , C07D209/08 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/89 , C07D267/08 , C07D277/28 , C07D277/36 , C07D295/155 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/38 , C07D333/70 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：US20080132503A1
公开(公告)日：2008-06-05
申请号：US11696880
申请日：2007-04-05
申请人： Oscar Moradei , Isabelle Paquin , Sylvie Frechette , Tammy Mallais , Simon Roy , Roger Machaalani , Arkadii Vaisburg , Jeffrey Besterman , Pierre Tessier , John Mancuso , David Smil , Silvana Leit , Robert Deziel
发明人： Oscar Moradei , Isabelle Paquin , Sylvie Frechette , Tammy Mallais , Simon Roy , Roger Machaalani , Arkadii Vaisburg , Jeffrey Besterman , Pierre Tessier , John Mancuso , David Smil , Silvana Leit , Robert Deziel
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/4535 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D333/02 , C07D401/02 , C07D401/14 , C07D403/02 , C07D403/14 , C07D409/02 , C07D413/02 , C12N9/99
CPC分类号： C07D333/36 , C07C235/56 , C07C237/40 , C07C271/28 , C07D207/12 , C07D207/14 , C07D207/325 , C07D209/08 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/89 , C07D267/08 , C07D277/28 , C07D277/36 , C07D295/155 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/38 , C07D333/70 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：US07253204B2
公开(公告)日：2007-08-07
申请号：US11090713
申请日：2005-03-25
申请人： Daniel Delorme , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain , Zhihong Zhou , Isabelle Paquin , Frederic Gaudette , Ljubomir Isakovic
发明人： Daniel Delorme , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain , Zhihong Zhou , Isabelle Paquin , Frederic Gaudette , Ljubomir Isakovic
IPC分类号： A61K31/4025 , C07D207/14
CPC分类号： C07C237/40 , C07C311/21 , C07C311/39 , C07D209/42 , C07D213/38 , C07D213/74 , C07D231/38 , C07D235/16 , C07D237/20 , C07D239/42 , C07D239/48 , C07D263/58 , C07D271/06 , C07D307/84 , C07D333/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/04 , C07D417/04 , C07D495/04
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：US20050245518A1
公开(公告)日：2005-11-03
申请号：US11090713
申请日：2005-03-25
申请人： Daniel Delorme , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain , Zhihong Zhou , Isabelle Paquin , Frederic Gaudette , Ljubomir Isakovic
发明人： Daniel Delorme , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain , Zhihong Zhou , Isabelle Paquin , Frederic Gaudette , Ljubomir Isakovic
IPC分类号： A61K31/4035 , A61K31/405 , A61K31/4439 , A61K31/496 , A61K31/4965 , A61K31/5377
CPC分类号： C07C237/40 , C07C311/21 , C07C311/39 , C07D209/42 , C07D213/38 , C07D213/74 , C07D231/38 , C07D235/16 , C07D237/20 , C07D239/42 , C07D239/48 , C07D263/58 , C07D271/06 , C07D307/84 , C07D333/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/04 , C07D417/04 , C07D495/04
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：US20070213330A1
公开(公告)日：2007-09-13
申请号：US11687398
申请日：2007-03-16
申请人： Daniel Delorme , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain , Zhihong Zhou , Isabelle Paquin , Frederic Gaudette , Ljubomir Isakovic
发明人： Daniel Delorme , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain , Zhihong Zhou , Isabelle Paquin , Frederic Gaudette , Ljubomir Isakovic
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4192 , A61K31/4439 , A61K31/428 , A61K31/405 , C07D417/02
CPC分类号： C07C237/40 , C07C311/21 , C07C311/39 , C07D209/42 , C07D213/38 , C07D213/74 , C07D231/38 , C07D235/16 , C07D237/20 , C07D239/42 , C07D239/48 , C07D263/58 , C07D271/06 , C07D307/84 , C07D333/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/04 , C07D417/04 , C07D495/04
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶。 本发明提供了抑制组蛋白脱乙酰酶酶活性的化合物和方法。 本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
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公开(公告)号：US20060058298A1
公开(公告)日：2006-03-16
申请号：US11081095
申请日：2005-03-15
申请人： Daniel Delorme , Soon Woo , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain
发明人： Daniel Delorme , Soon Woo , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain
IPC分类号： A61K31/5377 , A61K31/53 , A61K31/495 , A61K31/454 , A61K31/4015
CPC分类号： C07D401/04 , A61K31/4015 , A61K31/445 , A61K31/495 , A61K31/513 , A61K31/53 , A61K31/537 , C07C233/44 , C07C233/80 , C07C235/38 , C07C235/42 , C07C235/56 , C07C235/84 , C07C237/20 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/58 , C07C255/59 , C07C275/34 , C07C275/36 , C07C311/42 , C07C323/32 , C07C323/36 , C07C323/44 , C07C323/60 , C07C381/00 , C07D213/30 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D239/91 , C07D249/08 , C07D251/18 , C07D251/52 , C07D251/54 , C07D263/14 , C07D263/24 , C07D265/36 , C07D271/06 , C07D277/42 , C07D277/74 , C07D277/82 , C07D295/155 , C07D307/12 , C07D307/28 , C07D311/56 , C07D311/58 , C07D333/36 , C07D333/38 , C07D401/12 , C07D403/04 , C07D409/12 , C07D473/40 , C07D487/04 , C07D495/04 , C07D513/04 , C07F7/081 , C07F7/0812
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号：US07868204B2
公开(公告)日：2011-01-11
申请号：US11091025
申请日：2005-03-25
申请人： Daniel Delorme , Soon Hyung Woo , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain
发明人： Daniel Delorme , Soon Hyung Woo , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain
IPC分类号： C07C211/51 , C07C211/36 , C07D295/02 , C07D263/02 , C07D273/02 , C07D317/06 , C07D317/48 , C07D319/18 , A61K31/136 , A61K31/166 , A61K31/34 , A61K31/357 , A61P35/00
CPC分类号： A61K31/4015 , A61K31/445 , A61K31/495 , A61K31/513 , A61K31/53 , A61K31/537 , C07C233/44 , C07C233/80 , C07C235/38 , C07C235/42 , C07C235/56 , C07C235/84 , C07C237/20 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/58 , C07C255/59 , C07C275/34 , C07C275/36 , C07C311/42 , C07C323/32 , C07C323/36 , C07C323/44 , C07C323/60 , C07C381/00 , C07D213/30 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D239/91 , C07D249/08 , C07D251/18 , C07D251/52 , C07D251/54 , C07D263/14 , C07D263/24 , C07D265/36 , C07D271/06 , C07D277/42 , C07D277/74 , C07D277/82 , C07D295/155 , C07D307/12 , C07D307/28 , C07D311/56 , C07D311/58 , C07D333/36 , C07D333/38 , C07D401/12 , C07D403/04 , C07D409/12 , C07D473/40 , C07D487/04 , C07D495/04 , C07D513/04 , C07F7/081 , C07F7/0812
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶。 本发明提供了抑制组蛋白脱乙酰酶酶活性的化合物和方法。 本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
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公开(公告)号：US07595343B2
公开(公告)日：2009-09-29
申请号：US10242304
申请日：2002-09-12
申请人： Daniel Delorme , Soon Hyung Woo , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain
发明人： Daniel Delorme , Soon Hyung Woo , Arkadii Vaisburg , Oscar Moradei , Silvana Leit , Stephane Raeppel , Sylvie Frechette , Giliane Bouchain
IPC分类号： C07C211/51 , C07D239/24 , C07D239/72 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/14 , C07D409/12 , C07D405/12 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/136 , A61K31/166 , A61P35/00
CPC分类号： C07D213/30 , C07C15/18 , C07C233/44 , C07C233/80 , C07C235/38 , C07C235/42 , C07C235/56 , C07C235/84 , C07C237/20 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/58 , C07C255/59 , C07C275/34 , C07C275/36 , C07C311/42 , C07C323/32 , C07C323/36 , C07C323/44 , C07C323/60 , C07C381/00 , C07C2601/14 , C07C2602/08 , C07C2603/18 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D239/91 , C07D249/08 , C07D251/18 , C07D251/52 , C07D251/54 , C07D263/14 , C07D263/24 , C07D265/36 , C07D271/06 , C07D277/42 , C07D277/74 , C07D277/82 , C07D295/155 , C07D307/12 , C07D307/28 , C07D311/56 , C07D311/58 , C07D333/36 , C07D333/38 , C07D401/12 , C07D403/04 , C07D409/12 , C07D473/40 , C07D487/04 , C07D495/04 , C07D513/04 , C07F7/081 , C07F7/0812
摘要： The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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