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    Substituted purines and oligonucleotide cross-linking
    6.
    发明授权
    Substituted purines and oligonucleotide cross-linking 失效
    取代嘌呤和寡核苷酸交联

    公开(公告)号：US06232463B1

    公开(公告)日：2001-05-15

    申请号：US09128508

    申请日：1998-08-04

    申请人： Phillip Dan Cook ,  Muthiah Manoharan ,  Kanda S. Ramasamy

    发明人： Phillip Dan Cook ,  Muthiah Manoharan ,  Kanda S. Ramasamy

    IPC分类号： C07H2102

    CPC分类号： C07H19/16 ,  C07H19/20 ,  C07H21/00

    摘要： This invention is directed to novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as “antisense” agents—agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The compounds of the invention may also be used for cross-linking oligonucleotides. Oligonucleotides are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins, and cleaving RNA in site specific fashions. The compounds of the invention include novel heterocyclic bases, nucleosides, and nucleotides. when incorporated into oligonucleotides, the compounds of the invention can be useful for modulating the activity of RNA.

    摘要翻译： 本发明涉及用于包含在寡核苷酸中的新型基于嘌呤的化合物。 当掺入寡核苷酸时，本发明的化合物特别可用作能够与RNA的核苷酸序列特异性杂交的“反义”试剂。 本发明的化合物也可用于交联寡核苷酸。 寡核苷酸用于各种治疗和诊断目的，例如通过使用与这种RNA的反义相互作用来治疗疾病，调节实验系统中的基因表达，测定RNA和RNA产物，诊断疾病，调节蛋白质的产生， 并在现场具体时尚中切割RNA。 本发明化合物包括新的杂环碱基，核苷和核苷酸。 当掺入寡核苷酸时，本发明的化合物可用于调节RNA的活性。