中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

40 records (took 0.02 seconds)

    Mass tag analysis for rare cells and cell free molecules
    3.
    发明授权
    Mass tag analysis for rare cells and cell free molecules 有权

    公开(公告)号：US11531024B2

    公开(公告)日：2022-12-20

    申请号：US15762597

    申请日：2016-09-24

    Applicant: Purdue Research Foundation

    Inventor： Zane Baird ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    CHARGED MASS LABELING SYSTEM
    4.
    发明申请
    CHARGED MASS LABELING SYSTEM 有权

    公开(公告)号：US20210293826A1

    公开(公告)日：2021-09-23

    申请号：US17342804

    申请日：2021-06-09

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

    IPC: G01N33/68 ,  G01N33/531 ,  G01N33/574

    Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

    Ion focusing
    5.
    发明授权
    Ion focusing 有权

    公开(公告)号：US10923338B2

    公开(公告)日：2021-02-16

    申请号：US16987594

    申请日：2020-08-07

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/26 ,  H01J49/16

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    ION FOCUSING
    6.
    发明申请
    ION FOCUSING 审中-公开

    公开(公告)号：US20200381237A1

    公开(公告)日：2020-12-03

    申请号：US16987594

    申请日：2020-08-07

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    Ion focusing
    8.
    发明授权
    Ion focusing 有权

    公开(公告)号：US10777400B2

    公开(公告)日：2020-09-15

    申请号：US16803023

    申请日：2020-02-27

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    Ion focusing
    9.
    发明授权
    Ion focusing 有权

    公开(公告)号：US11830717B2

    公开(公告)日：2023-11-28

    申请号：US18134887

    申请日：2023-04-14

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    ION FOCUSING
    10.
    发明公开
    ION FOCUSING 审中-公开

    公开(公告)号：US20230260772A1

    公开(公告)日：2023-08-17

    申请号：US18134887

    申请日：2023-04-14

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

Patent Agency Ranking