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公开(公告)号:US20100166794A1
公开(公告)日:2010-07-01
申请号:US12722439
申请日:2010-03-11
申请人: Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
发明人: Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
IPC分类号: A61K39/002 , C07K14/445 , C07H21/04 , A61P33/06
CPC分类号: C07K14/445 , A61K39/00 , Y02A50/412
摘要: The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
摘要翻译: 本发明提供了分离的肝阶段疟原虫多肽,其包含选自SEQ ID NO:1-48的氨基酸序列及其免疫原性衍生物。 本发明还提供编码本发明的肝阶段疟原虫多肽的分离的核酸分子,包含本发明的一种或多种肝阶段疟原虫多肽的组合物,诱导针对肝阶段的疟原虫多肽的免疫应答的方法,以及治疗和诊断方法 肝阶段疟疾。
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公开(公告)号:US20090017055A1
公开(公告)日:2009-01-15
申请号:US12088065
申请日:2006-09-29
申请人: Patrick Duffy , Stefan H. I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
发明人: Patrick Duffy , Stefan H. I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
IPC分类号: A61K39/015 , C07K14/445 , C07H21/00 , A61P33/06
CPC分类号: C07K14/445 , A61K39/00 , Y02A50/412
摘要: The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
摘要翻译: 本发明提供了分离的肝阶段疟原虫多肽,其包含选自SEQ ID NO:1-48的氨基酸序列及其免疫原性衍生物。 本发明还提供编码本发明的肝阶段疟原虫多肽的分离的核酸分子,包含本发明的一种或多种肝阶段疟原虫多肽的组合物,诱导针对肝阶段的疟原虫多肽的免疫应答的方法,以及治疗和诊断方法 肝阶段疟疾。
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公开(公告)号:US07722889B2
公开(公告)日:2010-05-25
申请号:US12088065
申请日:2006-09-29
申请人: Patrick Duffy , Urszula Krzych , Donald G. Heppner, Jr. , Vladislav A. Malkov , Jason W. Wendler , Igor Bacik
发明人: Patrick Duffy , Urszula Krzych , Donald G. Heppner, Jr. , Vladislav A. Malkov , Jason W. Wendler , Igor Bacik
IPC分类号: A61K39/015 , C07K14/445 , C07H21/04 , C12P21/04
CPC分类号: C07K14/445 , A61K39/00 , Y02A50/412
摘要: The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
摘要翻译: 本发明提供了分离的肝阶段疟原虫多肽,其包含选自SEQ ID NO:1-48的氨基酸序列及其免疫原性衍生物。 本发明还提供编码本发明的肝阶段疟原虫多肽的分离的核酸分子,包含本发明的一种或多种肝阶段疟原虫多肽的组合物,诱导针对肝阶段的疟原虫多肽的免疫应答的方法,以及治疗和诊断方法 肝阶段疟疾。
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公开(公告)号:US08318183B2
公开(公告)日:2012-11-27
申请号:US12722439
申请日:2010-03-11
申请人: Patrick Duffy , Stefan H. I. Kappe , Urszula Krzych , Donald G. Heppner , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason P. Wendler , Igor Bacik
发明人: Patrick Duffy , Stefan H. I. Kappe , Urszula Krzych , Donald G. Heppner , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason P. Wendler , Igor Bacik
IPC分类号: A61K39/015 , C12P21/06 , C07H21/04
CPC分类号: C07K14/445 , A61K39/00 , Y02A50/412
摘要: The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
摘要翻译: 本发明提供了分离的肝阶段疟原虫多肽,其包含选自SEQ ID NO:1-48的氨基酸序列及其免疫原性衍生物。 本发明还提供编码本发明的肝阶段疟原虫多肽的分离的核酸分子,包含本发明的一种或多种肝阶段疟原虫多肽的组合物,诱导针对肝阶段的疟原虫多肽的免疫应答的方法,以及治疗和诊断方法 肝阶段疟疾。
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公开(公告)号:US5366227A
公开(公告)日:1994-11-22
申请号:US228707
申请日:1994-04-18
申请人: Patrick Duffy
发明人: Patrick Duffy
CPC分类号: A63F11/0002
摘要: A recycling game apparatus includes a toy vehicle having a plurality of bins for holding game pieces and having a card caddy thereon. A deck of cards is supported in the toy vehicle card caddy along with a plurality of game pieces with each game piece having a shaped emulative of a recycling member and stored in a marked bin. The game pieces can be moved into and out of the bins in playing the game. Each card in the deck of cards has information concerning one recycling item which is emulative of at least one game piece, such as aluminum, newspaper, glass, or plastic. Each toy vehicle plurality of bins may be marked with indicia to indicate aluminum, paper, glass, plastic, or trash. The toy vehicle is used to store the game with cards and pieces as well as used in playing the game.
摘要翻译: 回收游戏装置包括具有多个用于保持游戏件并且具有卡片盒的箱的玩具车。 多个卡片与多个游戏件一起支撑在玩具车卡片盒中,每个游戏件具有回收构件的成形模拟件并存储在标记的仓中。 游戏中的棋子可以在游戏中移入和移出。 卡片卡中的每张卡都有关于一个回收项目的信息,该回收项目是模拟至少一个游戏件,例如铝,报纸,玻璃或塑料。 每个玩具车辆的多个箱体可以标记有标记以表示铝,纸,玻璃,塑料或垃圾。 玩具车用于存储游戏卡片和片段,并用于玩游戏。
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公开(公告)号:US20240223582A1
公开(公告)日:2024-07-04
申请号:US18442883
申请日:2024-02-15
申请人: Patrick Duffy , Kelsey Mitchell , Peter Silberman
发明人: Patrick Duffy , Kelsey Mitchell , Peter Silberman
CPC分类号: H04L63/1416 , H04L41/22 , H04L63/20
摘要: A system and method for adapting one or more cybersecurity microservices to accelerate cybersecurity threat mitigation includes constructing a subscriber-specific data corpus comprising a plurality of distinct pieces of computing environment-informative data of a target subscriber; adapting a subscriber-agnostic microservice of the cybersecurity service to a subscriber-specific microservice, wherein: the subscriber-agnostic microservice includes a plurality of subscriber-agnostic cybersecurity event handling instructions, and adapting the subscriber-agnostic microservice to the subscriber-specific microservice includes generating a plurality of context-informed cybersecurity event handling instructions; augmenting the subscriber-agnostic microservice to include the plurality of context-informed cybersecurity event handling instructions; computing for a target cybersecurity event a subscriber-specific threat severity level based on one or more of the plurality of context-informed cybersecurity event handling instructions; executing, by one or more computers, a threat mitigation action or threat disposal action based on the computing of the subscriber-specific threat severity level for the target cybersecurity event.
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公开(公告)号:USD612276S1
公开(公告)日:2010-03-23
申请号:US29308919
申请日:2008-07-14
申请人: Patrick Duffy , Kerry Wilson , Jeff Williams
设计人: Patrick Duffy , Kerry Wilson , Jeff Williams
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公开(公告)号:US20070096763A1
公开(公告)日:2007-05-03
申请号:US11582829
申请日:2006-10-18
申请人: Jonathan Ehrmann , Patrick Duffy , Markus Weber , Gregg Metzger , Joseph Lento , Pierre-Yves Mabboux , Jens Zink , Yun Chu
发明人: Jonathan Ehrmann , Patrick Duffy , Markus Weber , Gregg Metzger , Joseph Lento , Pierre-Yves Mabboux , Jens Zink , Yun Chu
IPC分类号: G01R31/26
CPC分类号: G01R31/2891 , B23K26/032 , B23K26/042 , B23K26/0861 , B23K26/351 , B23K26/705
摘要: A laser processing system implements a method for aligning a probe element (e.g., a probe pin) with a device interface element (e.g., a contact pad of a circuit substrate). First, the laser processing system generates an optical reference beam at one or more predetermined positions to calibrate a reference field. The laser processing system then detects a position of the probe element in the reference field. The laser processing system also determines a relative position of the device interface element in the reference field. Based on the position of the probe element and the device interface element, the laser processing system then initiates alignment of the probe element and the device interface element. In one application, alignment of the probe element and the device interface element further includes contacting the probe element to the device interface element to make an electrical connection.
摘要翻译: 激光处理系统实现将探针元件(例如,探针)与装置接口元件(例如,电路基板的接触焊盘)对准的方法。 首先,激光处理系统在一个或多个预定位置处产生光学参考光束,以校准参考场。 激光处理系统然后在参考场中检测探针元件的位置。 激光处理系统还确定设备接口元件在参考场中的相对位置。 基于探针元件和器件接口元件的位置,激光加工系统然后启动探针元件和器件接口元件的对准。 在一个应用中,探针元件和器件接口元件的对准还包括将探针元件接触到器件接口元件以进行电连接。
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公开(公告)号:US20120258463A1
公开(公告)日:2012-10-11
申请号:US13474980
申请日:2012-05-18
申请人: Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
发明人: Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
CPC分类号: C12N15/1003 , B01L3/5082 , B01L7/52 , B01L9/06 , B01L9/527 , B01L2200/16 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/0099 , G01N35/026 , G01N35/1002 , G01N2035/00772 , G01N2035/00801 , G01N2035/00881 , G01N2035/0493 , Y10T436/113332
摘要: A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples.
摘要翻译: 用于容纳样品和各种试剂的支架,其中,在使用试剂之前,可以使用支架装载样品和试剂。 机架接受互补的试剂保持器,每个试剂容器包含用于进行预定处理操作的一组试剂,例如制备用于扩增和检测从样品提取的多核苷酸的生物样品。
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公开(公告)号:US20090136386A1
公开(公告)日:2009-05-28
申请号:US12178584
申请日:2008-07-23
申请人: Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
发明人: Patrick Duffy , Kerry Wilson , Kalyan Handique , Jeff Williams
IPC分类号: B01L9/06
CPC分类号: C12N15/1003 , B01L3/5082 , B01L7/52 , B01L9/06 , B01L9/527 , B01L2200/16 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/0099 , G01N35/026 , G01N35/1002 , G01N2035/00772 , G01N2035/00801 , G01N2035/00881 , G01N2035/0493
摘要: A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples.
摘要翻译: 用于容纳样品和各种试剂的支架,其中,在使用试剂之前,可以使用支架装载样品和试剂。 机架接受互补的试剂保持器,每个试剂容器包含用于进行预定处理操作的一组试剂,例如制备用于扩增和检测从样品提取的多核苷酸的生物样品。
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