公开(公告)号：US11845081B2

公开(公告)日：2023-12-19

申请号：US17131558

申请日：2020-12-22

申请人： HANDYLAB, INC.

发明人： Jeff Williams ,  Kerry Wilson ,  Kalyan Handique

IPC分类号： B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  F16K99/00 ,  B01L3/02 ,  B01L9/06 ,  G01N35/02 ,  G01N35/00 ,  G01N35/04

CPC分类号： B01L3/502761 ,  B01L3/0275 ,  B01L3/5027 ,  B01L3/52 ,  B01L7/52 ,  B01L9/06 ,  B01L9/527 ,  F16K99/0001 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0061 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/045 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0677 ,  B01L2400/0683 ,  F16K2099/0084 ,  G01N35/026 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0436

摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

公开(公告)号：US20230194018A1

公开(公告)日：2023-06-22

申请号：US18065055

申请日：2022-12-13

申请人： Commissariat à l'Energie Atomique et aux Energies Alternatives

发明人： Guillaume BLAIRE ,  Manuel ALESSIO ,  Mélissa BAQUE ,  Jean-Maxime ROUX

IPC分类号： F16K99/00

CPC分类号： F16K99/0032 ,  F16K99/0036 ,  F16K99/0055 ,  F16K2099/0084

摘要： A fluidic component intended to be associated with a heating module and in which there is formed a fluidic circuit including a fluidic channel intended for the circulation of a fluid, the fluidic channel including at least one passage for the fluid and a widened portion forming a location produced at the periphery of the passage, the component including a fluidic valve mechanism including at least an actuating element capable of expanding, trapped by at least one body made of a meltable compound in the location.

公开(公告)号：US10071376B2

公开(公告)日：2018-09-11

申请号：US14941087

申请日：2015-11-13

申请人： HANDYLAB, INC.

发明人： Jeff Williams ,  Kerry Wilson ,  Kalyan Handique

IPC分类号： G01N35/02 ,  B01L99/00 ,  B01L7/00 ,  B01L9/00 ,  B01L3/00 ,  F16K99/00 ,  B01L3/02 ,  B01L9/06 ,  G01N35/00 ,  G01N35/04

CPC分类号： B01L3/502761 ,  B01L3/0275 ,  B01L3/5027 ,  B01L3/52 ,  B01L7/52 ,  B01L9/06 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/045 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0677 ,  B01L2400/0683 ,  F16K99/0001 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/026 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0436

摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

公开(公告)号：US20170304826A1

公开(公告)日：2017-10-26

申请号：US15631547

申请日：2017-06-23

申请人： SAMSUNG ELECTRONICS CO., LTD.

发明人： Beom-seok LEE ,  Yoon-kyoung CHO ,  Jong-myeon PARK ,  Jeong-gun LEE

IPC分类号： B01L3/00 ,  G01N35/00

CPC分类号： B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

摘要： Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

公开(公告)号：US09789483B2

公开(公告)日：2017-10-17

申请号：US14205146

申请日：2014-03-11

申请人： Cue Inc.

发明人： Ayub Khattak ,  Clinton Sever

IPC分类号： G01N33/00 ,  B01L3/00 ,  G01N35/08 ,  G01N33/543 ,  H04M1/725 ,  G01N35/00 ,  G01N27/28 ,  B05D3/00 ,  F16K99/00 ,  C12Q1/68 ,  G01N33/58 ,  G01N1/02 ,  G01N35/10 ,  G01N21/78 ,  G01N27/327

CPC分类号： B01L3/502715 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5029 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0683 ,  B05D3/002 ,  B05D2518/00 ,  C12Q1/6825 ,  F16K99/0032 ,  F16K99/0036 ,  F16K2099/0084 ,  G01N1/02 ,  G01N21/78 ,  G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/581 ,  G01N35/00029 ,  G01N35/0098 ,  G01N35/08 ,  G01N35/1095 ,  G01N2001/027 ,  G01N2001/028 ,  G01N2035/00277 ,  G01N2035/00564 ,  G01N2458/30 ,  H04M1/72527 ,  H04M1/7253 ,  Y10T137/1797

摘要： This system takes in raw cellular material collected using a provided swab, blood collection device, urine collection device, or other sample collection device and transforms that biological material into a digital result, identifying the presence, absence and/or quantity of nucleic acids, proteins, and/or other molecules of interest.

公开(公告)号：US09605665B2

公开(公告)日：2017-03-28

申请号：US14322241

申请日：2014-07-02

申请人： Sensirion Holding AG

发明人： Felix Mayer

IPC分类号： F04B13/00 ,  F04B19/00 ,  F04B43/04 ,  F16K99/00 ,  A61M5/145 ,  A61M5/172 ,  F04B43/14 ,  F04B49/22

CPC分类号： F04B13/00 ,  A61M5/14586 ,  A61M5/172 ,  F04B19/006 ,  F04B43/043 ,  F04B43/14 ,  F04B49/22 ,  F16K99/0001 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0094

摘要： The pump is provided with a plurality of pumping chambers and electrically activatable valves. An elastic membrane is arranged in each pumping chamber and divides the same into a first and a second chamber section. Each valve is connected to the second chamber section of a pumping chamber. When a pressure drop is applied over the valve and the valve is activated (i.e. opened), the pressure in the second chamber section changes, which causes the membrane to move, which in turn leads to a change of the volumes of both chamber sections. This e.g. allows to pump well-defined amounts of fluid from the chamber sections to a drug dispensing device.

公开(公告)号：US09512935B2

公开(公告)日：2016-12-06

申请号：US14376432

申请日：2013-02-22

申请人： FONDS ESPCI GEORGES CHARPAK ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Clemence Vergne ,  Patrick Tabeling ,  Yvette Tran ,  Fabrice Monti ,  Lucie Devys

IPC分类号： B01L3/00 ,  F16K99/00 ,  F04B19/00 ,  B81B1/00 ,  B01L7/00

CPC分类号： F16K99/0026 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502776 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/161 ,  B01L2400/0421 ,  B01L2400/0481 ,  B01L2400/0677 ,  F04B19/006 ,  F16K99/0032 ,  F16K99/0036 ,  F16K99/0038 ,  F16K99/0049 ,  F16K99/0061 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/2191 ,  Y10T137/2196

摘要： A microchannel formed at the interface of two layers of material, at least one of the two materials being a substrate. A volume of the microchannel contains a film of polymer fixed by covalent bonding to the substrate layer. The film of polymer being formed from a hydrogel material susceptible to undergoing changes in volume under the action of an external stimulus. The hydrogel polymer is chosen from those which are sensitive to changes in temperature, light, electrical field or pH. A method for producing the microchannel.

摘要翻译： 在两层材料的界面处形成的微通道，两种材料中的至少一种是基底。 微通道的体积包含通过共价键合固定到基底层的聚合物膜。 聚合物膜由在外部刺激的作用下容易发生体积变化的水凝胶材料形成。 水凝胶聚合物选自对温度，光，电场或pH变化敏感的那些。 一种微通道的制造方法。

公开(公告)号：US09207245B2

公开(公告)日：2015-12-08

申请号：US14599375

申请日：2015-01-16

申请人： CUE INC.

发明人： Ayub Khattak

IPC分类号： G01N27/327 ,  G01N33/58 ,  G01N35/08 ,  G01N33/543 ,  H04M1/725 ,  B01L3/00 ,  G01N35/00 ,  G01N27/28 ,  B05D3/00 ,  F16K99/00 ,  C12Q1/68

CPC分类号： B01L3/502715 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/5029 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0683 ,  B05D3/002 ,  B05D2518/00 ,  C12Q1/6825 ,  F16K99/0032 ,  F16K99/0036 ,  F16K2099/0084 ,  G01N1/02 ,  G01N21/78 ,  G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/581 ,  G01N35/00029 ,  G01N35/0098 ,  G01N35/08 ,  G01N35/1095 ,  G01N2001/027 ,  G01N2001/028 ,  G01N2035/00277 ,  G01N2035/00564 ,  G01N2458/30 ,  H04M1/72527 ,  H04M1/7253 ,  Y10T137/1797

摘要： Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

公开(公告)号：US09186677B2

公开(公告)日：2015-11-17

申请号：US12218498

申请日：2008-07-14

申请人： Jeff Williams ,  Kerry Wilson ,  Kalyan Handique

发明人： Jeff Williams ,  Kerry Wilson ,  Kalyan Handique

IPC分类号： G01N35/02 ,  B01L99/00 ,  B01L7/00 ,  B01L3/00 ,  B01L9/00 ,  F16K99/00 ,  G01N35/00 ,  G01N35/04

CPC分类号： B01L3/502761 ,  B01L3/0275 ,  B01L3/5027 ,  B01L3/52 ,  B01L7/52 ,  B01L9/06 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/045 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0677 ,  B01L2400/0683 ,  F16K99/0001 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/026 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0436

摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

公开(公告)号：US09080207B2

公开(公告)日：2015-07-14

申请号：US13692929

申请日：2012-12-03

申请人： HANDYLAB, INC.

发明人： Kalyan Handique ,  Sundaresh N Brahmasandra ,  Karthik Ganesan ,  Jeff Williams

IPC分类号： C12Q1/68 ,  C12P19/34 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  F16K99/00 ,  G01N35/00

CPC分类号： C12Q1/6806 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/045 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0442 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0611 ,  B01L2400/0677 ,  B01L2400/0683 ,  C12Q1/686 ,  F16K99/0001 ,  F16K99/003 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2035/00881

摘要： The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.

摘要翻译： 本技术提供了用于检测样品中特别是生物样品中多核苷酸的装置。 该技术更特别涉及在微流体通道内对感兴趣的核苷酸进行PCR并检测这些核苷酸的微流体系统。 该装置包括被配置为接受多个样品并且可以分别对每个样品或一组或多个样品同时进行PCR的微流控盒。