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1.发明申请MICROFLUIDIC ANALYTICAL DEVICE FOR ANALYSIS OF CHEMICAL OR BIOLOGICAL SAMPLES, METHOD AND SYSTEM THEREOF 审中-公开用于化学或生物样品分析的微流化分析装置，其方法和系统公开(公告)号：US20090311796A1
公开(公告)日：2009-12-17
申请号：US12482707
申请日：2009-06-11
申请人： Patrick Griss , Rainer Jaeggi , Goran Savatic , Vuk Siljegovic
发明人： Patrick Griss , Rainer Jaeggi , Goran Savatic , Vuk Siljegovic
CPC分类号： B01L3/50273 , B01L2200/10 , B01L2300/0654 , B01L2300/0803 , B01L2300/0887 , B01L2300/168 , B01L2400/0409 , B01L2400/0688 , C12Q1/54 , G01N21/07 , G01N33/491 , Y10T436/144444 , Y10T436/146666 , Y10T436/15 , Y10T436/166666 , Y10T436/171538 , Y10T436/175383 , Y10T436/201666 , Y10T436/204165
摘要： An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.
摘要翻译： 公开了用于分析化学或生物样品的分析装置，基于装置的旋转，集成的样品计量和光学检测使用这种装置的方法，以及包括这种装置的系统。 分析装置包括具有液体处理单元的装置主体。 液体处理单元包括用于将样品与试剂混合的混合室，用于将限定体积的样品输送到混合室的样品计量室，以及用于输送要与样品混合的试剂的试剂通道，其中 混合室也用作检测室。
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公开(公告)号：US07586612B2
公开(公告)日：2009-09-08
申请号：US11463110
申请日：2006-08-08
IPC分类号： G01N21/00
CPC分类号： G01N21/0303 , B01L3/502715 , B01L2300/0654 , B01L2300/0806 , B01L2300/168 , G01N35/00069
摘要： On an analytical device for photometric analysis of chemistry and/or fluid samples comprising a rotatable disk-like body, a plurality of receptacles for fluid samples and optics for guiding light beams through the receptacles are arranged. At least part of the optics are designed and/or arranged such that at least part of the light beams is deflected and guided through the receptacles at an angle to the radially outward direction on the disk-like body which means at an angle to the radius, connecting the respective optics with the rotation axis of the disk-like body.
摘要翻译： 在用于对包括可旋转的盘状体的化学和/或流体样品进行光度分析的分析装置上，布置了多个用于流体样品的容器和用于将光束引导通过容器的光学器件。 光学元件的至少一部分被设计和/或布置成使得至少部分光束被偏转并且引导通过插座与盘状主体上的径向向外方向成一定角度，这意味着与半径成一定角度 将各光学元件与盘状体的旋转轴连接。
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公开(公告)号：US20070165229A1
公开(公告)日：2007-07-19
申请号：US11463110
申请日：2006-08-08
IPC分类号： G01N21/00
CPC分类号： G01N21/0303 , B01L3/502715 , B01L2300/0654 , B01L2300/0806 , B01L2300/168 , G01N35/00069
摘要： On a analytical device for photometric analysis of chemistry and/or fluid samples comprising a rotatable disk-like body (1) a plurality of receptacles (7) for fluid samples and optical means (9) for guiding light beams through the receptacles are arranged. At least part of the optical means (9) are designed and/or arranged such that at least part of the light beams is deflected and guided through the receptacles at an angle to the radially outward direction on the disk-like body (1) which means at an angle to the radius, connecting the respective optical means with the rotation axis (3) of the disk-like body (1).
摘要翻译： 在用于对包括可旋转盘状体（1）的化学和/或流体样品进行光度分析的分析装置上，布置有用于流体样品的多个容器（7）和用于将光束引导通过容器的光学装置（9）。 光学装置（9）的至少一部分被设计和/或布置成使得至少部分光束被偏转和引导通过插座与盘状主体（1）上的径向向外方向成一角度， 意指与半径成一定角度，将相应的光学装置与盘状体（1）的旋转轴线（3）相连接。
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公开(公告)号：US08814808B2
公开(公告)日：2014-08-26
申请号：US12879500
申请日：2010-09-10
申请人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.
摘要翻译： 体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。 在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。 孔尺寸可以较小，例如具有0.01至0.5mm的直径。 这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。 在一些实施例中，孔的深度为50至500μm。 在其它实施方案中，收集区是多孔的，或者是粗糙区域。 收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。 在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。
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公开(公告)号：US08162854B2
公开(公告)日：2012-04-24
申请号：US11470021
申请日：2006-09-05
申请人： Irio G. Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
发明人： Irio G. Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
IPC分类号： B65D81/00
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element (10) having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving element (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving element initially. The fluid receiving element may have a test zone (45) for performing an analytical reaction. Fluid from the channel is contacted with the fluid receiving element either by bringing the fluid receiving element and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving element.
摘要翻译： 体液取样装置包括具有用于接收体液的流体通道（11）的皮肤刺穿元件（10），所述流体通道的至少一部分对环境开放，并且还包括间隔开的流体接收元件（40） 从流体通路使得通道中的流体最初不会接触流体接收元件。 流体接收元件可以具有用于进行分析反应的测试区（45）。 通过将流体接收元件和流体机械接触或将流体从通道电输送到流体接收元件上，来自通道的流体与流体接收元件接触。
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公开(公告)号：US09022952B2
公开(公告)日：2015-05-05
申请号：US13421163
申请日：2012-03-15
IPC分类号： A61B5/00 , A61B5/145 , A61B5/15 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element having a fluid pathway for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.
摘要翻译： 体液取样装置包括具有用于接收体液的流体通道的皮肤刺穿元件，所述流体通道的至少一部分对环境开放，并且还包括与所述流体通道间隔开的流体接收装置， 通路最初不会接触流体接收装置。 所述流体接收装置可以具有用于进行分析反应的测试区域。 来自所述通道的流体与所述流体接收装置接触，通过使流体接收装置和流体进入机械接触或者将流体从通道电输送到流体接收装置上。
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公开(公告)号：US08636675B2
公开(公告)日：2014-01-28
申请号：US12901290
申请日：2010-10-08
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。
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公开(公告)号：US20120174688A1
公开(公告)日：2012-07-12
申请号：US13421163
申请日：2012-03-15
IPC分类号： G01N1/00
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element having a fluid pathway for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.
摘要翻译： 体液取样装置包括具有用于接收体液的流体通道的皮肤刺穿元件，所述流体通道的至少一部分对环境开放，并且还包括与所述流体通道间隔开的流体接收装置， 通路最初不会接触流体接收装置。 所述流体接收装置可以具有用于进行分析反应的测试区域。 来自所述通道的流体与所述流体接收装置接触，通过使流体接收装置和流体进入机械接触或者将流体从通道电输送到流体接收装置上。
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公开(公告)号：US07833172B2
公开(公告)日：2010-11-16
申请号：US11868505
申请日：2007-10-07
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。
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公开(公告)号：US20080290048A1
公开(公告)日：2008-11-27
申请号：US12131512
申请日：2008-06-02
申请人： Rainer Jaeggi , Patrick Griss , Hans-Peter Wahl
发明人： Rainer Jaeggi , Patrick Griss , Hans-Peter Wahl
CPC分类号： G01N21/07 , B01L3/502746 , B01L3/502753 , B01L2300/0806 , B01L2300/0816 , B01L2300/0858 , B01L2300/0864 , B01L2400/0409 , B01L2400/086 , G01N33/491
摘要： A device and method thereof for at least partially fractioning or separating fluid from higher density and/or solid particles contained in liquid samples are disclosed. The present invention provides a movable or drivable device having a flow path defined by inner and outer wall surfaces and arranged such that the flow velocity of the liquid sample along the outer wall surface is higher than the flow velocity along the opposite inner wall surface. The flow path provides elements to at least delay the flow of the liquid sample along the outer wall surface. The device is, e.g., suitable for the separation of blood, e.g., of plasma from at least red blood cells, and from red and white blood cells to achieve blood plasma with high purity for analytical reasons.
摘要翻译： 公开了一种用于至少部分地分馏或分离液体样品中包含的较高密度和/或固体颗粒的流体的装置及其方法。 本发明提供了一种可移动或可驱动的装置，其具有由内壁和外壁表面限定的流动路径，并且布置成使得液体样品沿着外壁表面的流速高于沿着相对的内壁表面的流速。 流动路径提供元件以至少延迟液体样品沿着外壁表面的流动。 例如，该装置适于从至少红细胞和红细胞和白细胞分离血液，例如血浆，以实现高纯度的血浆，用于分析的原因。
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