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公开(公告)号：US20110123636A1
公开(公告)日：2011-05-26
申请号：US12992525
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K9/14 , C12N5/02 , A61K31/7088 , C08F226/06 , C08F220/34
CPC分类号： A61K31/713 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F290/062 , C08F293/005 , C12N15/111 , C12N15/87 , C12N2320/32 , Y02A50/463
摘要： Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
摘要翻译： 本文提供了包含多种共聚物的胶束组合物。 在某些情况下，本文提供的胶束组件是pH敏感颗粒。
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公开(公告)号：US09339558B2
公开(公告)日：2016-05-17
申请号：US12992525
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K9/16 , A61K9/50 , C12N5/00 , C12N5/02 , C08F293/00 , C08F295/00 , C08F297/00 , A61K48/00 , A61K9/107 , C08F290/06 , C12N15/11 , C12N15/87
CPC分类号： A61K31/713 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F290/062 , C08F293/005 , C12N15/111 , C12N15/87 , C12N2320/32 , Y02A50/463
摘要： Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
摘要翻译： 本文提供了包含多种共聚物的胶束组合物。 在某些情况下，本文提供的胶束组件是pH敏感颗粒。
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公开(公告)号：US20110143435A1
公开(公告)日：2011-06-16
申请号：US12992536
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
CPC分类号： A61K47/488 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , C08F293/005 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/14
摘要： Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
摘要翻译： 本文提供适合于将多核苷酸（例如寡核苷酸）和/或其它治疗剂递送至活细胞的聚合物载体。
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公开(公告)号：US20110129921A1
公开(公告)日：2011-06-02
申请号：US12992545
申请日：2009-05-13
申请人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Chen-Chang Lee , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Chen-Chang Lee , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
CPC分类号： C07H21/02 , A61K47/58 , Y10T428/2982
摘要： Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer.
摘要翻译： 聚合物生物共轭物具有共价偶联于pH依赖性的膜去稳定化聚合物的α或ω末端的RNAi试剂。
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公开(公告)号：US09006193B2
公开(公告)日：2015-04-14
申请号：US12992536
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E. E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E. E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K47/48 , A01N43/04 , A61K48/00 , A61K47/30 , C12Q1/68 , C12N15/00 , C08F120/18 , C12N15/87 , A61K9/107 , C08F293/00
CPC分类号： A61K47/488 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , C08F293/005 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/14
摘要： Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
摘要翻译： 本文提供适合于将多核苷酸（例如寡核苷酸）和/或其它治疗剂递送至活细胞的聚合物载体。
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6.发明申请DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS 有权二嵌段共聚物和多核苷酸复合物，用于递送至细胞公开(公告)号：US20110143434A1
公开(公告)日：2011-06-16
申请号：US12992517
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
IPC分类号： C12N5/071 , C08F293/00
CPC分类号： C08F293/005 , A61K31/713 , A61K47/32 , A61K47/58 , C07K2319/10 , C08F293/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/351 , C12N2320/32
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
摘要翻译： 本文描述的是共聚物，以及制备和利用这些共聚物的方法。 这样的共聚物具有至少两个嵌段：在生理pH下具有至少一个亲水性单元的第一嵌段和具有疏水基团的第二嵌段。 该第二嵌段还具有至少一个具有在约生理pH下为阴离子基团的单元。 所述共聚物破坏细胞膜，包括细胞外膜，细胞内膜，囊泡，细胞器，内体，脂质体或红细胞。 优选地，在某些情况下，共聚物破坏膜并进入细胞内环境。 在具体实例中，共聚物是内体分解的。
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7.发明授权Diblock copolymers and polynucleotide complexes thereof for delivery into cells 有权二嵌段共聚物和其多核苷酸复合物用于递送到细胞中公开(公告)号：US09476063B2
公开(公告)日：2016-10-25
申请号：US12992517
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
IPC分类号： C08F293/00 , C12N5/071 , C12N15/87 , C12N15/11
CPC分类号： C08F293/005 , A61K31/713 , A61K47/32 , A61K47/58 , C07K2319/10 , C08F293/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/351 , C12N2320/32
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
摘要翻译： 本文描述的是共聚物，以及制备和利用这些共聚物的方法。 这样的共聚物具有至少两个嵌段：在生理pH下具有至少一个亲水性单元的第一嵌段和具有疏水基团的第二嵌段。 该第二嵌段还具有至少一个具有在约生理pH下为阴离子基团的单元。 所述共聚物破坏细胞膜，包括细胞外膜，细胞内膜，囊泡，细胞器，内体，脂质体或红细胞。 优选地，在某些情况下，共聚物破坏膜并进入细胞内环境。 在具体实例中，共聚物是内体分解的。
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8.发明授权Nanoparticles for controlled release of anti-biofilm agents and methods of use 有权用于控制释放抗生物膜剂的纳米颗粒及其使用方法公开(公告)号：US09566247B2
公开(公告)日：2017-02-14
申请号：US14768945
申请日：2014-02-25
IPC分类号： A61K9/50 , A61K31/045 , A61K31/352 , C08F293/00 , B82Y5/00 , C08L53/00
CPC分类号： A61K9/5026 , A61K31/045 , A61K31/352 , B82Y5/00 , C08F293/005 , C08L53/00
摘要： The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed.
摘要翻译： 本发明涉及治疗和/或预防生物膜和生物膜相关疾病的组合物和方法。 本发明包括纳米颗粒载体（NPC）和其中的至少一种治疗剂。 NPC在生物膜内和表面处于生物膜形成和积累的风险中，同时在触发释放时提供治疗剂的局部，持续，增强和控制的递送。 在一个实施方案中，NPC包含pH响应元件，其允许当局部环境指示当最需要时精细地递送药剂时特异性递送治疗剂。
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9.发明申请Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use 审中-公开用于控制释放抗生物膜剂的纳米颗粒及其使用方法公开(公告)号：US20150374634A1
公开(公告)日：2015-12-31
申请号：US14768945
申请日：2014-02-25
IPC分类号： A61K9/50 , A61K31/352 , A61K31/045
CPC分类号： A61K9/5026 , A61K31/045 , A61K31/352 , B82Y5/00 , C08F293/005 , C08L53/00
摘要： The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed.
摘要翻译： 本发明涉及治疗和/或预防生物膜和生物膜相关疾病的组合物和方法。 本发明包括纳米颗粒载体（NPC）和其中的至少一种治疗剂。 NPC在生物膜内和表面处于生物膜形成和积累的风险中，同时在触发释放时提供治疗剂的局部，持续，增强和控制的递送。 在一个实施方案中，NPC包含pH响应元件，其允许当局部环境指示当最需要时精细地递送药剂时特异性递送治疗剂。
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公开(公告)号：US09193954B2
公开(公告)日：2015-11-24
申请号：US14004776
申请日：2012-04-02
申请人： Michael Hoffman , Danielle Benoit
发明人： Michael Hoffman , Danielle Benoit
IPC分类号： C12N5/071 , C12N5/00 , C12N5/0775
CPC分类号： C12N5/0662 , C12N5/0012 , C12N5/0663 , C12N2501/727
摘要： Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3′-oxime (BIO). This results in robust proliferation and “stemness” in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog.
摘要翻译： 提供了增加间充质干细胞增殖的方法。 该方法需要使细胞与6-溴靛玉红-3'-肟（BIO）接触。 这导致了强力增殖和“干性”的剂量依赖性，如两个干细胞基因的基因表达所示：Sox2和Nanog。
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