公开(公告)号：US10209330B2

公开(公告)日：2019-02-19

申请号：US14006069

申请日：2012-03-22

申请人： Paul A. Bottomley ,  Refaat Gabr ,  Yi Zhang ,  Robert G. Weiss

发明人： Paul A. Bottomley ,  Refaat Gabr ,  Yi Zhang ,  Robert G. Weiss

IPC分类号： G01R33/46 ,  G01R33/485 ,  G01R33/483

摘要： A method of performing spatially localized magnetic resonance spectroscopy includes receiving a magnetic resonance image of an object; identifying a plurality C of compartments that generate magnetic resonance spectroscopy signals in the object including at least one compartment of interest; segmenting in at least one spatial dimension the magnetic resonance image of the object into the C compartments; acquiring magnetic resonance spectroscopy signals from the compartments by applying a plurality of M′ phase encodings applied in the at least one spatial dimension, wherein M′≥C; calculating a spatially localized magnetic resonance chemical shift spectrum from the at least one compartment of interest; and rendering a spatially localized magnetic resonance spectrum that is substantially equal to a spatial average of magnetic resonance chemical shift spectra from the at least one compartment of interest. A magnetic resonance spectroscopy and imaging system is configured to perform the above method.

公开(公告)号：US20140015529A1

公开(公告)日：2014-01-16

申请号：US14006069

申请日：2012-03-22

申请人： Paul A. Bottomley ,  Refaat Gabr ,  Yi Zhang

发明人： Paul A. Bottomley ,  Refaat Gabr ,  Yi Zhang

IPC分类号： G01R33/46

CPC分类号： G01R33/46 ,  G01R33/483 ,  G01R33/485

摘要： A method of performing spatially localized magnetic resonance spectroscopy includes receiving a magnetic resonance image of an object; identifying a plurality C of compartments that generate magnetic resonance spectroscopy signals in the object including at least one compartment of interest; segmenting in at least one spatial dimension the magnetic resonance image of the object into the C compartments; acquiring magnetic resonance spectroscopy signals from the compartments by applying a plurality of M′ phase encodings applied in the at least one spatial dimension, wherein M′≧C; calculating a spatially localized magnetic resonance chemical shift spectrum from the at least one compartment of interest; and rendering a spatially localized magnetic resonance spectrum that is substantially equal to a spatial average of magnetic resonance chemical shift spectra from the at least one compartment of interest. A magnetic resonance spectroscopy and imaging system is configured to perform the above method.

摘要翻译： 执行空间局部磁共振波谱的方法包括：接收物体的磁共振图像; 识别在所述对象中产生磁共振光谱信号的多个C隔室，所述区域包括至少一个感兴趣的隔间; 在至少一个空间维度上将物体的磁共振图像分割成C隔间; 通过应用在所述至少一个空间维度中施加的多个M'相位编码来从所述隔间获取磁共振光谱信号，其中M'= C; 从所述至少一个感兴趣区室计算空间局部化的磁共振化学位移谱; 以及渲染基本上等于来自所述至少一个感兴趣区室的磁共振化学位移谱的空间平均值的空间局部磁共振谱。 磁共振光谱学和成像系统被配置为执行上述方法。

公开(公告)号：US09791489B2

公开(公告)日：2017-10-17

申请号：US14005804

申请日：2012-03-22

申请人： Paul A. Bottomley ,  William Edelstein ,  Abdel-Monem M. El-Sharkawy ,  Di Qian

发明人： Paul A. Bottomley ,  William Edelstein ,  Abdel-Monem M. El-Sharkawy ,  Di Qian

IPC分类号： G01R27/32 ,  G01R21/00 ,  G01R33/36 ,  A61N1/00 ,  G06F1/00 ,  G01R1/00 ,  G01R21/10 ,  G01R33/28

CPC分类号： G01R27/32 ,  A61N1/00 ,  G01R1/00 ,  G01R21/00 ,  G01R21/10 ,  G01R33/288 ,  G01R33/3614 ,  G06F1/00 ,  G06F2101/00

摘要： A device with at least one channel for measuring high dynamic range, radio frequency (RF) power levels over broad-ranging duty cycles includes a power sensor circuit comprising at least one logarithmic amplifier; at least one directional RF coupler electrically connected to the at least one power sensor; at least one RF attenuator electrically connected to the at least one RF coupler; and at least one sampling circuit electrically connected to the at least one RF attenuator and the at least one RF coupler. The at least one sampling circuit performs analog-to-digital conversion of electrical signals received to provide digitals signals for measuring the RF power level in the at least one channel.

公开(公告)号：US08717021B2

公开(公告)日：2014-05-06

申请号：US12677097

申请日：2008-09-08

申请人： Paul A. Bottomley ,  John P. Stralka

发明人： Paul A. Bottomley ,  John P. Stralka

IPC分类号： G01V3/00

CPC分类号： G01R33/288 ,  G01R33/58

摘要： Featured is a dosimeter device that measures SAR deposited by RF power deposition during MRI of a specimen. Such a dosimeter device includes a transducer that is configured to present a load to the MRI scanner in which the transducer is located and to provide an output representative of signals induced in the transducer. The transducer also is configured so that the presented load is substantially equivalent to another load which would be presented by the specimen during MRI of the specimen. Such a transducer also is configured so as to generate an MRI signal that is sufficient to allow the MRI scanner to adjust the RF power to a value substantially equal to that of the specimen. Also featured are methods for measuring SAR deposited by RF power deposition and apparatuses or system embodying such a dosimeter device.

摘要翻译： 特色是一种剂量计装置，可以在样品的MRI期间测量通过RF功率沉积沉积的SAR。 这样一种剂量计装置包括一个换能器，该换能器被配置为向换能器所在的MRI扫描器提供负载，并提供代表在换能器中感应的信号的输出。 传感器还被配置成使得所呈现的负载基本上等于在样本的MRI期间由样本呈现的另一负载。 这样的换能器也被配置为产生足以使MRI扫描器将RF功率调整到基本上等于样本的值的MRI信号。 还有一些用于测量通过RF功率沉积沉积的SAR的方法以及体现这种剂量计装置的装置或系统。

公开(公告)号：US20110037468A1

公开(公告)日：2011-02-17

申请号：US12879430

申请日：2010-09-10

申请人： Paul A. Bottomley ,  Ananda Kumar

发明人： Paul A. Bottomley ,  Ananda Kumar

IPC分类号： G01R33/44

CPC分类号： G01R33/3415 ,  G01R33/3678

摘要： Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer≧1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to be about nλ/4, where n is an integer≧1 and λ is the wavelength of the signal to be detected. The length of the strip also is such as to be substantially in the approximate range of 1.3 times the depth of interest. The strip conductors are also combined with loop coils to form quadrature detectors.

摘要翻译： 特色是用于激发核的NMR或MRI信号以及相关设备，系统和方法的设备。 该装置包括带状阵列天线，其包括一个或多个导体和N个非反应调谐组件，其中N是整数≥1，N个无功分量中的至少一个电耦合到一个或多个导体中的每一个以及接地/ 虚拟地面。 导体的表观电长度用无功调谐分量进行调谐，因此等于大约nλ/ 4，其中n是整数≧1，λ是待检测信号的波长。 条的长度也基本上在感兴趣深度的1.3倍的近似范围内。 带状导体也与环形线圈组合以形成正交检测器。

公开(公告)号：US20100274252A1

公开(公告)日：2010-10-28

申请号：US12766481

申请日：2010-04-23

申请人： Paul A. Bottomley ,  Shashank Sathyanarayana

发明人： Paul A. Bottomley ,  Shashank Sathyanarayana

IPC分类号： A61B17/60

CPC分类号： A61B17/708

摘要： Featured is a reduction instrument being configured and arranged to allow correction of vertebral translation and applying distraction across a segment in an independent fashion. Such a reduction instrument embodies one or more identical modules that are configured as needed for correcting the deformity. In more particular embodiments, each of the one or more modules has two degrees of freedom (DOF) with uncoupled orthogonal translations. Such a reduction instrument allows the reorientation of the vertebral segment as needed via uncoupled orthogonal translations. Such a reduction instrument also is usable in combination with a plurality of vertebral anchors, such vertebral anchors being any such vertebral anchors as are know to those skilled in the art (e.g., conventional spinal pedicle screw instrumentation) or hereinafter developed so as to form a spinal implant system. Also featured are treatment methods utilizing such a reduction instrument.

摘要翻译： 特色是一种减少仪器，其被配置和布置成允许校正脊椎翻译并以独立方式跨越段进行牵引。 这种还原器具体现了一个或多个相同的模块，其被配置为需要校正畸形。 在更具体的实施例中，一个或多个模块中的每一个具有具有未耦合正交平移的两个自由度（DOF）。 这种减少器械允许根据需要通过非耦合的正交平移重新定向椎骨段。 这种减速器还可以与多个椎骨锚固件组合使用，这些椎骨锚固件是本领域技术人员已知的任何这样的椎骨锚固件（例如，常规的椎弓根螺钉装置）或下文开发以形成 脊柱植入系统。 还特征在于使用这种还原装置的处理方法。

公开(公告)号：US20080262584A1

公开(公告)日：2008-10-23

申请号：US12047832

申请日：2008-03-13

申请人： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore ,  J. Michael Shifflette

发明人： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore ,  J. Michael Shifflette

IPC分类号： A61N1/05 ,  H01B7/06 ,  G01N3/20

CPC分类号： A61N1/08 ,  A61N1/0488 ,  A61N1/05 ,  A61N1/086 ,  B29C33/126 ,  B29L2031/753 ,  G01N3/32 ,  Y10T29/49071

摘要： MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.

摘要翻译： MRI / RF兼容引线包括至少一个导体，具有至少一个具有多层堆叠线圈配置的段的相应导体。 引线可以被配置为使得铅在局部组织中加热小于约10摄氏度（通常约5摄氏度或更低），或者当患者暴露于至少峰值输入SAR的目标RF频率时不加热局部组织 约4W / kg和/或全身平均SAR至少约2W / kg。 还描述了制造引线的相关引线和方法。

公开(公告)号：US06675033B1

公开(公告)日：2004-01-06

申请号：US09536090

申请日：2000-03-24

申请人： Albert C. Lardo ,  Xiaoming Yang ,  Ergin Atalar ,  Parag Karmarkar ,  Elliott R. McVeigh ,  Henry R. Halperin ,  Christine Enger McNamara ,  Paul A. Bottomley

发明人： Albert C. Lardo ,  Xiaoming Yang ,  Ergin Atalar ,  Parag Karmarkar ,  Elliott R. McVeigh ,  Henry R. Halperin ,  Christine Enger McNamara ,  Paul A. Bottomley

IPC分类号： A61B5055

CPC分类号： G01R33/287 ,  G01R33/34084

摘要： The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI, can act as an antenna and receive MRI signals from surrounding subject matter, and can allow the use of multiple interventional tools without removal of the guidewire from a subject.

摘要翻译： 本发明描述了可以在MRI上可见的用于MRI导丝的系统，方法和装置，可用作天线并从周围主题接收MRI信号，并且可以允许使用多个介入工具而不去除导丝 从一个主题。

公开(公告)号：US06628980B2

公开(公告)日：2003-09-30

申请号：US09817893

申请日：2001-03-26

申请人： Ergin Atalar ,  Paul A. Bottomley ,  Parag Karmarkar ,  Albert C. Lardo ,  Elias Zerhouni

发明人： Ergin Atalar ,  Paul A. Bottomley ,  Parag Karmarkar ,  Albert C. Lardo ,  Elias Zerhouni

IPC分类号： A61B5055

CPC分类号： A61B1/00154 ,  A61B5/055 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3958 ,  G01R33/285 ,  G01R33/34007 ,  G01R33/34084

摘要： The apparatus, systems and methods of the present invention provide for MRI sleeves, probes, and combinations thereof adapted for insertion into a subject, in order to internally image regions of the subject.

公开(公告)号：US4682106A

公开(公告)日：1987-07-21

申请号：US714405

申请日：1985-03-21

申请人： Dimitrios Vatis ,  Paul A. Bottomley ,  Thomas H. Foster

发明人： Dimitrios Vatis ,  Paul A. Bottomley ,  Thomas H. Foster

IPC分类号： G01R33/48 ,  A61B5/055 ,  A61B10/00 ,  G01N24/12 ,  G01R33/46 ,  G01R33/485 ,  G01R33/08

CPC分类号： G01R33/485 ,  G01R33/46

摘要： A method for proton decoupling, nuclear Overhauser enhancement and/or in selective saturation magnetic resonance spectroscopy, particularly relevant to in vivo spectroscopic imaging, utilizes a radio-frequency pulse modulated with a truncated (sinc X)/X function capable of being windowed. The radio-frequency pulse is tuned to the frequency of the nuclear species, such as .sup.1 H, to be decoupled or saturated and has a bandwidth adjusted to correspond to the entire chemical shift spectrum of the nuclear species to be decoupled, minimizing the amount of radio-frequency power transmitted into a volume of the irradiated sample. Several methods, and several embodiments of apparatus, for forming the required radio-frequency pulse, are disclosed.

摘要翻译： 特别是与体内光谱成像相关的用于质子解耦，核Overhauser增强和/或选择性饱和磁共振光谱的方法利用能够被窗口化的截短（sinc X）/ X函数调制的射频脉冲。 射频脉冲被调谐到诸如1H的核物质的频率被解耦或饱和，并且具有调整的带宽以对应于待解耦的核物质的整个化学位移谱，最小化无线电量 射频功率传输到被照射样品的体积中。 公开了用于形成所需射频脉冲的几种方法和装置的若干实施例。