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    Fish disease models and uses thereof
    1.
    发明申请
    Fish disease models and uses thereof 审中-公开
    鱼病模型及其用途

    公开(公告)号：US20060115895A1

    公开(公告)日：2006-06-01

    申请号：US10537258

    申请日：2003-12-01

    申请人： Paul Goldsmith ,  Angeleen Fleming ,  Andrew McGlashan Richards ,  Derek Jones ,  William Harris

    发明人： Paul Goldsmith ,  Angeleen Fleming ,  Andrew McGlashan Richards ,  Derek Jones ,  William Harris

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/40 ,  A01K2267/03 ,  C12N2830/008

    摘要： Generation and use of disease models, for instance in assays to identify and investigate genes and substances involved in disease and disease treatment, identification and use of drug targets. In particular, the present invention relates to generation and use of disease models in fish such as zebrafish. Gradable phenotypes may be generated in fish, allowing for degree of correction or alteration of an activity or effect of a treatment, gene or mutation to be assayed. Competing stimuli may be applied to fish in screens assaying for ability to affect an activity or effect of a treatment, gene or mutation. Example include any combination of an addictive drug, a visual stimulus, an audible startle stimulus, a temperature gradient, an electric shock, an aversive compound, a threatening shape or a dark area.

    摘要翻译： 疾病模型的生成和使用，例如用于鉴定和调查涉及疾病和疾病治疗的基因和物质的鉴定和使用的测定中。 特别地，本发明涉及鱼类如斑马鱼中疾病模型的产生和使用。 可能在鱼中产生可梯度表型，允许修正程度或改变待测定的活性或作用，基因或突变。 竞争刺激可以在筛选测定影响治疗，基因或突变的活性或作用的能力的筛选中应用于鱼。 示例包括成瘾药物，视觉刺激，可听惊厥刺激，温度梯度，电击，厌恶化合物，威胁形状或黑暗区域的任何组合。

    MODIFIED LATEX DRAG REDUCER AND PROCESSES THEREFOR AND THEREWITH
    3.
    发明申请
    MODIFIED LATEX DRAG REDUCER AND PROCESSES THEREFOR AND THEREWITH 有权
    改进的LATEX减速器及其过程及其应用

    公开(公告)号：US20070240762A1

    公开(公告)日：2007-10-18

    申请号：US11768856

    申请日：2007-06-26

    申请人： William Harris ,  Kenneth Smith ,  Stuart Milligan ,  Ray Johnston ,  Vincent Anderson

    发明人： William Harris ,  Kenneth Smith ,  Stuart Milligan ,  Ray Johnston ,  Vincent Anderson

    IPC分类号： F17D1/18 ,  C08L23/00 ,  C08L31/00 ,  C08L39/00 ,  C08L47/00

    CPC分类号： F17D1/17 ,  C09K2208/28 ,  Y10T137/0391

    摘要： A modified latex drag reducer and methods of making and using the drag reducer in order to reduce friction losses resulting from turbulent fluid flow through a conduit. Particularly, the modified latex drag reducer is formed from an initial latex which is a product of an emulsion polymerization reaction. The initial latex is then modified, preferably by admixing with at least one low HLB surfactant or at least one solvent, or both, to form a modified latex with an enhanced dissolution rate in a hydrocarbon stream over the initial latex.

    摘要翻译： 改进的胶乳减阻剂以及制造和使用减阻剂的方法，以减少由流动通过导管的紊流引起的摩擦损失。 特别地，改性乳胶减阻剂由乳液聚合反应产物的初始胶乳形成。 然后将初始胶乳改性，优选通过与至少一种低HLB表面活性剂或至少一种溶剂或两者混合来形成具有在初始胶乳中的烃流中增强的溶解速率的改性胶乳。

    Cap with removable and rotatable visor
    4.
    发明申请
    Cap with removable and rotatable visor 审中-公开
    帽子带有可移动和可旋转的遮阳板

    公开(公告)号：US20070017003A1

    公开(公告)日：2007-01-25

    申请号：US11177833

    申请日：2005-07-08

    申请人： William Harris ,  Jocelyn Harris

    发明人： William Harris ,  Jocelyn Harris

    IPC分类号： A42B1/00

    CPC分类号： A42B1/064

    摘要： A cap comprises a crown sized to fit on a wearer's head and a visor. The cap includes a track mounted to the crown and a slide member to which said visor is mounted. The visor can be removably mounted in the slide member to allow for changing the cap's visor. The slide member can move axially along the track, to allow for selective positioning of the visor on the cap. Additionally, the slide member can be an articulated slide member which allows for altering the relative angular position of the visor relative to the crown.

    摘要翻译： 帽子包括尺寸适合佩戴者的头部和遮阳板的冠。 盖包括安装到冠部的轨道和安装有所述遮阳板的滑动构件。 遮阳板可拆卸地安装在滑动构件中，以允许更换盖子的遮阳板。 滑动构件可以沿着轨道轴向移动，以允许将遮阳板选择性地定位在盖上。 另外，滑动构件可以是铰接的滑动构件，其允许改变面罩相对于表冠的相对角位置。

    Bicyclic nitrogen heterocycles
    7.
    发明授权
    Bicyclic nitrogen heterocycles 失效
    双环氮杂环

    公开(公告)号：US6150373A

    公开(公告)日：2000-11-21

    申请号：US422451

    申请日：1999-10-21

    申请人： William Harris ,  Christopher Huw Hill ,  Ian Edward David Smith

    发明人： William Harris ,  Christopher Huw Hill ,  Ian Edward David Smith

    IPC分类号： A61K31/505 ,  A61K31/519 ,  A61P3/10 ,  A61P9/00 ,  A61P11/06 ,  A61P17/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D487/04 ,  A01N43/54 ,  C07D487/00

    CPC分类号： C07D487/04

    摘要： Amino-substituted dihydropyrimido[4,5-d]pyrimidinones of the formula in which R.sup.1 represents hydrogen, lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl, R.sup.2 represents lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl, and R.sup.3 represents hydrogen, lower alkyl, aryl, aryl-lower alkyl, heteroaryl, heteroaryl-lower alkyl, lower cycloalkyl, lower cycloalkenyl or lower cycloalkyl-lower alkyl, and pharmaceutically acceptable salts thereof are protein kinase inhibitors. They can be used in the treatment or prophylaxis of inflammatory, immunological, oncological, bronchopulmonary, dermatological and cardiovascular disorders, in the treatment of asthma, central nervous system disorders or diabetic complications or for the prevention of graft rejection following transplant surgery.

    摘要翻译： 其中R 1表示氢，低级烷基，芳基，芳基 - 低级烷基，杂芳基，杂芳基 - 低级烷基，低级环烷基或低级环烷基 - 低级烷基的下式的氨基取代二氢嘧啶并[4,5-d] 烷基，芳基，芳基 - 低级烷基，杂芳基，杂芳基 - 低级烷基，低级环烷基或低级环烷基 - 低级烷基，R3代表氢，低级烷基，芳基，芳基 - 低级烷基，杂芳基，杂芳基 - 低级烷基，低级环烷基， 低级环烯基或低级环烷基 - 低级烷基及其药学上可接受的盐是蛋白激酶抑制剂。 它们可用于治疗或预防炎症，免疫学，肿瘤学，支气管肺，皮肤病和心血管疾病，用于治疗哮喘，中枢神经系统疾病或糖尿病并发症，或用于预防移植手术后的移植排斥反应。

    DEFLECTABLE CATHETER SYSTEMS AND METHODS OF USE
    8.
    发明申请
    DEFLECTABLE CATHETER SYSTEMS AND METHODS OF USE 有权

    公开(公告)号：US20210338984A1

    公开(公告)日：2021-11-04

    申请号：US17245291

    申请日：2021-04-30

    申请人： Robert Booker ,  William Harris ,  Deborah Norris ,  Rupert Barton ,  Frances Penrose ,  John Hiles

    发明人： Robert Booker ,  William Harris ,  Deborah Norris ,  Rupert Barton ,  Frances Penrose ,  John Hiles

    IPC分类号： A61M25/01 ,  A61M25/00 ,  A61B17/34

    摘要： Example deflectable catheter systems are described. An example deflectable catheter system includes a housing, an orienting member, an actuator, a first elongate member, a second elongate member, and a wire member. The housing defines a passageway. The orienting member is attached to the housing. The actuator is attached to the orienting member and is moveable between an actuator first position and an actuator second position. The first elongate member is attached to the orienting member and defines a lumen. The first elongate member is moveable between a first, substantially straight configuration when the actuator is in the actuator first position and a second, curved configuration when the actuator is in the actuator second position. The second elongate member is disposed through the passageway of the housing and extends through the lumen defined by the first elongate member. The second elongate member is rotatable relative to the first elongate member.

    Secondary current compensation method
    10.
    发明申请
    Secondary current compensation method 有权
    二次电流补偿方式

    公开(公告)号：US20060290330A1

    公开(公告)日：2006-12-28

    申请号：US11157924

    申请日：2005-06-22

    申请人： William Harris ,  Jerry Adams

    发明人： William Harris ,  Jerry Adams

    IPC分类号： G05F1/00

    CPC分类号： H02M3/33507

    摘要： Techniques for correcting for internal resistance losses in the secondary windings of a transformer to reduce errors in output voltage from a high voltage power supply.

    摘要翻译： 用于校正变压器次级绕组内部电阻损耗的技术，以减少高压电源的输出电压误差。