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    Fish disease models and uses thereof
    1.
    发明申请
    Fish disease models and uses thereof 审中-公开
    鱼病模型及其用途

    公开(公告)号：US20060115895A1

    公开(公告)日：2006-06-01

    申请号：US10537258

    申请日：2003-12-01

    申请人： Paul Goldsmith ,  Angeleen Fleming ,  Andrew McGlashan Richards ,  Derek Jones ,  William Harris

    发明人： Paul Goldsmith ,  Angeleen Fleming ,  Andrew McGlashan Richards ,  Derek Jones ,  William Harris

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/40 ,  A01K2267/03 ,  C12N2830/008

    摘要： Generation and use of disease models, for instance in assays to identify and investigate genes and substances involved in disease and disease treatment, identification and use of drug targets. In particular, the present invention relates to generation and use of disease models in fish such as zebrafish. Gradable phenotypes may be generated in fish, allowing for degree of correction or alteration of an activity or effect of a treatment, gene or mutation to be assayed. Competing stimuli may be applied to fish in screens assaying for ability to affect an activity or effect of a treatment, gene or mutation. Example include any combination of an addictive drug, a visual stimulus, an audible startle stimulus, a temperature gradient, an electric shock, an aversive compound, a threatening shape or a dark area.

    摘要翻译： 疾病模型的生成和使用，例如用于鉴定和调查涉及疾病和疾病治疗的基因和物质的鉴定和使用的测定中。 特别地，本发明涉及鱼类如斑马鱼中疾病模型的产生和使用。 可能在鱼中产生可梯度表型，允许修正程度或改变待测定的活性或作用，基因或突变。 竞争刺激可以在筛选测定影响治疗，基因或突变的活性或作用的能力的筛选中应用于鱼。 示例包括成瘾药物，视觉刺激，可听惊厥刺激，温度梯度，电击，厌恶化合物，威胁形状或黑暗区域的任何组合。

    Safety arrangement
    3.
    发明授权
    Safety arrangement 有权
    安全安排

    公开(公告)号：US07699157B2

    公开(公告)日：2010-04-20

    申请号：US11753637

    申请日：2007-05-25

    申请人： Julian Poyner ,  Derek Jones ,  Derek Sawyer ,  Burt Sacherski ,  Francis L. Leard

    发明人： Julian Poyner ,  Derek Jones ,  Derek Sawyer ,  Burt Sacherski ,  Francis L. Leard

    IPC分类号： B65G47/24 ,  B65G29/00 ,  B65G47/00

    CPC分类号： F16P3/00 ,  B65G43/00 ,  B65G2207/40

    摘要： A safety arrangement for use with a piece of equipment. The safety arrangement includes a signal generating unit for generating an optical signal, an elongate element, and a signal detecting unit. The elongate element is disposed along, about, around or through the piece of equipment and is capable of transmitting an optical signal. The signal detecting unit detects an optical signal. The signal generating unit is connected to the signal detecting unit by the elongate element such that the signal detecting unit is in optical communication with the signal detecting unit. The signal detecting unit is arranged to detect a change in the optical signal transmitted by the elongate element as a consequence of movement of the elongate element and, upon detection of the change in the signal, the detecting unit is configured to effect a change in the operation of the piece of equipment.

    摘要翻译： 用于一件设备的安全布置。 安全装置包括用于产生光信号的信号产生单元，细长元件和信号检测单元。 细长元件沿着，围绕，围绕或穿过该设备设置，并且能够传输光学信号。 信号检测单元检测光信号。 信号发生单元通过细长元件连接到信号检测单元，使得信号检测单元与信号检测单元光通信。 信号检测单元被布置为检测由细长元件的移动而由细长元件传输的光信号的变化，并且在检测到信号的变化时，检测单元被配置为实现 该设备的操作。

    Safety Switch
    4.
    发明申请
    Safety Switch 有权
    安全开关

    公开(公告)号：US20090194405A1

    公开(公告)日：2009-08-06

    申请号：US12336130

    申请日：2008-12-16

    申请人： Julian Poyner ,  Derek Jones ,  Derek Sawyer

    发明人： Julian Poyner ,  Derek Jones ,  Derek Sawyer

    IPC分类号： H01H3/42

    CPC分类号： H01H27/002 ,  H01H9/16

    摘要： A safety switch for affecting the operating state of equipment to which the safety switch is at least indirectly connected. The safety switch includes a configuration, such as a number of contacts, that is arranged to change from a first condition to a second condition depending on whether or not an actuator has been engaged with or disengaged from the safety switch. The safety switch includes an arrangement for determining information that is at least indicative of an operational property of the configuration, and for storing information that is at least indicative of the obtained information.

    摘要翻译： 用于影响安全开关至少间接连接的设备的运行状态的安全开关。 安全开关包括诸如多个触点的构造，其被布置为根据执行器是否已经与安全开关接合或分离而从第一状态改变到第二状态。 安全开关包括用于确定至少指示配置的操作属性并且用于存储至少指示获得的信息的信息的信息的装置。

    Safety switch mounting
    8.
    发明授权
    Safety switch mounting 有权
    安全开关安装

    公开(公告)号：US07563995B2

    公开(公告)日：2009-07-21

    申请号：US11960174

    申请日：2007-12-19

    申请人： Derek Jones

    发明人： Derek Jones

    IPC分类号： H01H27/00

    CPC分类号： H01H9/22 ,  H01H27/002

    摘要： A mounting arrangement includes a first mounting that is attachable to a first support structure and configured to cooperate with one of a safety switch and a safety switch actuator and a second mounting configured to cooperate with the other of the safety switch and the safety switch actuator. The first and second mountings provide variable guided interaction between the first and second mountings and thereby provided variable guided interaction between the safety switch and the safety switch actuator.

    摘要翻译： 安装装置包括第一安装件，其可连接到第一支撑结构并且构造成与安全开关和安全开关致动器中的一个配合，以及构造成与安全开关和安全开关致动器中的另一个协作的第二安装件。 第一和第二安装件在第一和第二安装件之间提供可变的引导相互作用，从而在安全开关和安全开关致动器之间提供可变的引导相互作用。

    SAFETY ARRANGEMENT
    9.
    发明申请
    SAFETY ARRANGEMENT 有权
    安全安排

    公开(公告)号：US20080289937A1

    公开(公告)日：2008-11-27

    申请号：US11753637

    申请日：2007-05-25

    申请人： Julian Poyner ,  Derek Jones ,  Derek Sawyer ,  Burt Sacherski ,  Francis L. Leard

    发明人： Julian Poyner ,  Derek Jones ,  Derek Sawyer ,  Burt Sacherski ,  Francis L. Leard

    IPC分类号： B65G21/00 ,  G01V8/10 ,  G02B6/02 ,  G08C19/36

    CPC分类号： F16P3/00 ,  B65G43/00 ,  B65G2207/40

    摘要： A safety arrangement for use with a piece of equipment. The safety arrangement includes a signal generating unit for generating an optical signal, an elongate element, and a signal detecting unit. The elongate element is disposed along, about, around or through the piece of equipment and is capable of transmitting an optical signal. The signal detecting unit detects an optical signal. The signal generating unit is connected to the signal detecting unit by the elongate element such that the signal detecting unit is in optical communication with the signal detecting unit. The signal detecting unit is arranged to detect a change in the optical signal transmitted by the elongate element as a consequence of movement of the elongate element and, upon detection of the change in the signal, the detecting unit is configured to effect a change in the operation of the piece of equipment.

    摘要翻译： 用于一件设备的安全布置。 安全装置包括用于产生光信号的信号产生单元，细长元件和信号检测单元。 细长元件沿着，围绕，围绕或穿过该设备设置，并且能够传输光学信号。 信号检测单元检测光信号。 信号发生单元通过细长元件连接到信号检测单元，使得信号检测单元与信号检测单元光通信。 信号检测单元被布置为检测由细长元件的移动而由细长元件传输的光信号的变化，并且在检测到信号的变化时，检测单元被配置为实现 该设备的操作。