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    CD40-L INHIBITORY PHYLOMER PEPTIDES
    2.
    发明申请
    CD40-L INHIBITORY PHYLOMER PEPTIDES 有权
    CD40-L抑制物质蛋白酶

    公开(公告)号：US20120065134A1

    公开(公告)日：2012-03-15

    申请号：US13003726

    申请日：2009-07-13

    申请人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    发明人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    IPC分类号： A61K38/02 ,  A61P37/06 ,  C07K19/00 ,  A61P7/04 ,  A61P31/12 ,  C07K2/00 ,  A61P29/00 ,  A61P35/00

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C07K7/08

    摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.

    摘要翻译： 本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基抑制剂。 更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。 本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

    Method of determining, identifying or isolating cell-penetrating peptides
    3.
    发明授权
    Method of determining, identifying or isolating cell-penetrating peptides 有权

    公开(公告)号：US09880151B2

    公开(公告)日：2018-01-30

    申请号：US14112512

    申请日：2012-05-23

    申请人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    发明人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    IPC分类号： G01N33/50 ,  C07K14/47 ,  C40B60/12

    CPC分类号： G01N33/5014 ,  C07K14/4723 ,  C07K2319/00 ,  C07K2319/74 ,  C12N2503/02 ,  C40B60/12

    摘要： The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

    Method of Determining, Identifying or Isolating Cell-Penetrating Peptides
    4.
    发明申请
    Method of Determining, Identifying or Isolating Cell-Penetrating Peptides 有权
    确定，鉴定或分离细胞穿透肽的方法

    公开(公告)号：US20140141452A1

    公开(公告)日：2014-05-22

    申请号：US14112512

    申请日：2012-05-23

    申请人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    发明人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5014 ,  C07K14/4723 ,  C07K2319/00 ,  C07K2319/74 ,  C12N2503/02 ,  C40B60/12

    摘要： The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

    摘要翻译： 本发明提供了确定或鉴定或分离具有细胞类型选择性和/或至少能够通过动物受试者的血液脑屏障的细胞穿透肽（CPP）或其类似物或衍生物的方法。 本发明还提供CPP及其类似物及其衍生物，例如序列表SEQ ID NO：1-27所列的那些，以及包含一种或多种CPP的组合物，包括其中CPP或其类似物或衍生物的缀合物 与货物分子有关。 本发明还提供了将货物分子跨细胞膜运送到细胞内的特定位置，以及用于治疗，预防和/或诊断本发明的CPP或类似物或衍生物所连接的货物分子可治疗的疾病的方法。 本发明还提供用于鉴定或分离CPP的定制肽文库。

    CD40-L Inhibitory Peptides
    5.
    发明授权
    CD40-L Inhibitory Peptides 有权
    CD40-L抑制肽

    公开(公告)号：US08802634B2

    公开(公告)日：2014-08-12

    申请号：US13003726

    申请日：2009-07-13

    申请人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    发明人： Paul Michael Watt ,  Richard Hopkins ,  Katrin Hoffman

    IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/00 ,  A61K39/385

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C07K7/08

    摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.

    摘要翻译： 本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基抑制剂。 更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。 本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。

    Genetic Screen for Interaction Interface Mapping
    8.
    发明申请
    Genetic Screen for Interaction Interface Mapping 审中-公开
    交互界面映射的遗传屏幕

    公开(公告)号：US20080044815A1

    公开(公告)日：2008-02-21

    申请号：US10558863

    申请日：2004-05-31

    申请人： Paul Michael Watt ,  Richard Hopkins ,  Marie Bogoyevitch

    发明人： Paul Michael Watt ,  Richard Hopkins ,  Marie Bogoyevitch

    IPC分类号： C12Q1/68

    CPC分类号： C12N15/1055 ,  C12Q1/6897 ,  C12Q2565/201

    摘要： The present invention provides improved reverse hybrid assay methods for identifying amino acid residues within a protein that are required for its interaction or physical association with another protein, wherein disruption of an interaction between a protein of interest and its binding partner protein is assayed for a library of mutations of said protein of interest, and maintenance of an interaction between the protein of interest and another binding partner is assayed simultaneously in a single step, thereby reducing the incidence of uninformative mutations in the protein of interest that are detected.

    摘要翻译： 本发明提供了改进的用于鉴定蛋白质内与氨基酸残基相互作用或与另一种蛋白质相互作用所必需的氨基酸残基的改进的反向杂交测定方法，其中分析目标蛋白质与其结合配偶体蛋白质之间相互作用的破坏， 的所述目的蛋白质的突变，以及在一个步骤中同时测定目的蛋白质和另一个结合配偶体之间的相互作用的维持，从而降低检测到的感兴趣的蛋白质中的不知情突变的发生率。