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    Skin resurfacing and treatment using biocompatible materials
    1.
    发明申请
    Skin resurfacing and treatment using biocompatible materials 审中-公开
    使用生物相容性材料进行皮肤表面重建和治疗

    公开(公告)号：US20050059940A1

    公开(公告)日：2005-03-17

    申请号：US10810290

    申请日：2004-03-26

    申请人： Paul Weber ,  Michael Weber ,  Luiz Da Silva

    发明人： Paul Weber ,  Michael Weber ,  Luiz Da Silva

    IPC分类号： A61B17/00 ,  A61M35/00 ,  A61M37/00

    CPC分类号： A61M35/00 ,  A61B2017/00761 ,  A61M37/00

    摘要： Biocompatible materials are propelled at the skin with sufficient velocity to cause desired resurfacing of skin layers to the desired penetration depth. The materials, such as dry ice or water ice, are harmonious with the human body and thus eliminate foreign body reactions. Various materials may be used in combination, including local anesthetics and vasoconstrictors in solid or liquid form. The biocompatible solid or liquid particles are suspended in a cold carrier fluid and propelled through an insulated delivery system to the surface of the skin. The treatment of diseased skin lesions may be accomplished using the present invention as a drug delivery system.

    摘要翻译： 生物相容性材料以足够的速度在皮肤上推进，以使皮肤层的所需表面重新形成所需的穿透深度。 材料如干冰或水冰与人体和谐，从而消除异物反应。 可以组合使用各种材料，包括固体或液体形式的局部麻醉剂和血管收缩剂。 生物相容性固体或液体颗粒悬浮在冷载体流体中，并通过绝缘递送系统推进到皮肤表面。 可以使用本发明作为药物递送系统来治疗患病的皮肤损伤。

    Optically generated ultrasound for enhanced drug delivery
    3.
    发明授权
    Optically generated ultrasound for enhanced drug delivery 失效
    光学产生的超声波用于增强药物输送

    公开(公告)号：US06484052B1

    公开(公告)日：2002-11-19

    申请号：US09281371

    申请日：1999-03-30

    申请人： Steven R. Visuri ,  Heather L. Campbell ,  Luiz Da Silva

    发明人： Steven R. Visuri ,  Heather L. Campbell ,  Luiz Da Silva

    IPC分类号： A61N130

    CPC分类号： A61M37/0092 ,  A61B2018/263 ,  A61M2037/0007

    摘要： High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

    摘要翻译： 类似于超声的高频声波可以增强治疗性化合物递送到细胞中。 所递送的化合物可以是化疗药物，抗生素，光动力药物或基因疗法。 治疗性化合物系统地或优选局部施用于靶向部位。 取决于进入路线的位置，可以通过针头，插管或通过各种血管导管实现局部输送。 为了增强治疗化合物的全身或局部递送，在靶位点局部产生高频声波，优选在化合物给药部位附近产生高频声波。 声波通过与吸收介质的激光辐射相互作用产生，并且可以通过热弹性膨胀，热力学蒸发，材料消融或等离子体形成来产生。 声波具有临时透化局部细胞膜的作用，增加治疗化合物向细胞的扩散，允许减少全身剂量，减少副作用，并使新疗法成为可能。

    Optical fiber head for providing lateral viewing
    4.
    发明授权
    Optical fiber head for providing lateral viewing 有权

    公开(公告)号：US06466713B2

    公开(公告)日：2002-10-15

    申请号：US09883513

    申请日：2001-06-18

    申请人： Matthew J. Everett ,  Billy W. Colston ,  Dale L. James ,  Steve Brown ,  Luiz Da Silva

    发明人： Matthew J. Everett ,  Billy W. Colston ,  Dale L. James ,  Steve Brown ,  Luiz Da Silva

    IPC分类号： G02B626

    CPC分类号： G02B6/241 ,  A61B5/0066 ,  A61B5/0084 ,  G02B6/262

    摘要： The head of an optical fiber comprising the sensing probe of an optical heterodyne sensing device includes a planar surface that intersects the perpendicular to axial centerline of the fiber at a polishing angle &thgr;. The planar surface is coated with a reflective material so that light traveling axially through the fiber is reflected transverse to the fiber's axial centerline, and is emitted laterally through the side of the fiber. Alternatively, the planar surface can be left uncoated. The polishing angle &thgr; must be no greater than 39° or must be at least 51°. The emitted light is reflected from adjacent biological tissue, collected by the head, and then processed to provide real-time images of the tissue. The method for forming the planar surface includes shearing the end of the optical fiber and applying the reflective material before removing the buffer that circumscribes the cladding and the core.

    Opto-acoustic transducer for medical applications
    5.
    发明授权
    Opto-acoustic transducer for medical applications 失效
    用于医疗应用的光学传感器

    公开(公告)号：US06379325B1

    公开(公告)日：2002-04-30

    申请号：US09350494

    申请日：1999-07-09

    申请人： William Benett ,  Peter Celliers ,  Luiz Da Silva ,  Michael Glinsky ,  Richard London ,  Duncan Maitland ,  Dennis Matthews ,  Peter Krulevich ,  Abraham Lee

    发明人： William Benett ,  Peter Celliers ,  Luiz Da Silva ,  Michael Glinsky ,  Richard London ,  Duncan Maitland ,  Dennis Matthews ,  Peter Krulevich ,  Abraham Lee

    IPC分类号： A61B1720

    CPC分类号： A61B18/26 ,  A61B17/2202 ,  A61B2017/00106 ,  A61B2017/22084 ,  A61B2090/378

    摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

    摘要翻译： 本发明是用于在生物介质中产生声振动的光学激活换能器。 传感器位于可以位于导管内的光纤的端部。 用于操作换能器的能量由通过光纤传输到换能器的激光光学地提供。 脉冲激光被吸收在换能器的工作流体中，以产生热压力并随之导致换能器头部的绝热膨胀，使其对环境介质起作用。 传感器通过热冷却过程返回到其原始状态。 传感器在环境介质中的运动将声能耦合到介质中。 通过以高重复率脉冲激光（其可以从CW变化到100kHz），可以在介质中局部地建立超声辐射场。 这种生产超声波振动的方法可以在体内用于治疗人类中风相关病症，特别是用于溶解血栓。 导管还可以掺入抗血栓溶解药物治疗作为辅助治疗，并且其可以与用于成像和反馈控制的超声波检测设备结合操作。

    Automated cryogenic skin treatment
    6.
    发明授权
    Automated cryogenic skin treatment 有权
    自动低温皮肤治疗

    公开(公告)号：US07963959B2

    公开(公告)日：2011-06-21

    申请号：US12617565

    申请日：2009-11-12

    申请人： Luiz Da Silva ,  Donald Cohen ,  Marc Lieberman

    发明人： Luiz Da Silva ,  Donald Cohen ,  Marc Lieberman

    IPC分类号： A61B18/02

    CPC分类号： A61B18/0218 ,  A61B90/361 ,  A61B2017/00084 ,  A61B2017/00747

    摘要： An apparatus and methods for treating lesions on skin are presented. The apparatus collects information about a lesion and can automatically determine a course of treatment for the lesion. The device can include a controller that positions the nozzle proximate to a surface region of the lesion and automatically dispenses a pulse of the cryogenic fluid from the nozzle. The controller then positions the nozzle proximate to another surface region of the lesion and automatically dispenses a pulse of the cryogenic fluid from the nozzle.

    摘要翻译： 提出了一种治疗皮肤病变的装置和方法。 该装置收集关于病变的信息，并且可以自动确定病变的治疗过程。 该装置可以包括控制器，其将喷嘴定位成靠近病变的表面区域并且自动地从喷嘴分配低温流体的脉冲。 然后，控制器将喷嘴定位在病变的另一表面区域附近，并自动从喷嘴分配低温流体的脉冲。

    MULTISENSOR PROBE FOR TISSUE IDENTIFICATION
    7.
    发明申请
    MULTISENSOR PROBE FOR TISSUE IDENTIFICATION 失效
    用于组织鉴定的多传感器探针

    公开(公告)号：US20080306391A1

    公开(公告)日：2008-12-11

    申请号：US12196769

    申请日：2008-08-22

    申请人： Richard HULAR ,  Luiz Da Silva ,  Charles Chase

    发明人： Richard HULAR ,  Luiz Da Silva ,  Charles Chase

    IPC分类号： A61B5/00

    CPC分类号： A61B5/6848 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/061 ,  A61B5/145 ,  A61B5/6885 ,  A61B2017/00796 ,  A61B2090/062 ,  A61B2562/0242

    摘要： A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A retractable sheath may be disposed around the distal section of the needle to protect the needle when not in use. The sheath retracts when the probe is inserted into tissue and the position of the sheath relative to the needle may be measured to determine the needle's depth. Systems and methods for tissue identification are also provided.

    摘要翻译： 用于连续实时组织鉴定的多传感器探头。 多传感器探针包括组织穿刺针，用于表征组织的多个传感器和位置传感器，以测量针进入被诊断的组织的深度。 传感器包括但不限于光学散射和吸收光谱传感器，光学相干畴反射测量传感器，电阻抗传感器，温度传感器，pO2传感器，化学传感器和用于识别组织的其它传感器。 传感器可以采用延伸穿过所述针的多根光纤的形式。 可伸缩护套可以设置在针的远端部分周围，以在不使用时保护针头。 当探头插入组织中时，护套缩回，并且可以测量护套相对于针的位置以确定针的深度。 还提供了用于组织鉴定的系统和方法。

    Photoacoustic removal of occlusions from blood vessels
    8.
    发明申请
    Photoacoustic removal of occlusions from blood vessels 审中-公开
    光声消除血管闭塞

    公开(公告)号：US20050021013A1

    公开(公告)日：2005-01-27

    申请号：US10241741

    申请日：2002-09-10

    申请人： Steven Visuri ,  Luiz Da Silva ,  Peter Celliers ,  Richard London ,  Duncan Maitland ,  Victor Esch

    发明人： Steven Visuri ,  Luiz Da Silva ,  Peter Celliers ,  Richard London ,  Duncan Maitland ,  Victor Esch

    IPC分类号： A61B17/22 ,  A61B18/20 ,  A61B18/22 ,  A61B18/24 ,  A61N5/06 ,  A61B18/18

    CPC分类号： A61B18/245 ,  A61B2018/20359 ,  A61B2018/2211

    摘要： Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamic flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombi and emboli) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photoacoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamic flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.

    摘要翻译： 通过将光纤阵列定位在通道中并沿着纤维一次一个地引导处理辐射脉冲来去除人体内的流体通道的部分或完全闭塞，以产生冲击波和流体动力学流动，其冲击和乳化 闭塞。 优选的应用是从小脑血管移除血块（血栓和栓塞）以逆转缺血性卒中的作用。 选择操作参数和技术以最小化在该光声处理期间发生的脆弱的脑血管壁的加热量。 一种这样的技术是当期望发生流体动力学流动产生蒸汽气泡的存在并且阻止沿着不产生这种气泡的光纤传播的发热脉冲时的光学监测。