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1.发明申请Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids 有权用于体内并入非天然氨基酸的正交翻译组分公开(公告)号：US20080233611A1
公开(公告)日：2008-09-25
申请号：US11665083
申请日：2005-10-27
申请人： Peter G. Schultz , Lital Alfonta , Jonathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng
发明人： Peter G. Schultz , Lital Alfonta , Jonathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入到在细菌宿主细胞如大肠杆菌或真核宿主如酵母细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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2.发明申请Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids 审中-公开用于体内并入非天然氨基酸的正交翻译组分公开(公告)号：US20130244245A1
公开(公告)日：2013-09-19
申请号：US13492296
申请日：2012-06-08
申请人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
发明人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入在诸如大肠杆菌或真核宿主如酵母细胞中的细胞宿主细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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3.发明授权Orthogonal translation components for the in vivo incorporation of unnatural amino acids 有权用于体内引入非天然氨基酸的正交翻译组分公开(公告)号：US09102932B2
公开(公告)日：2015-08-11
申请号：US13492296
申请日：2012-06-08
申请人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
发明人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入在诸如大肠杆菌或真核宿主如酵母细胞中的细胞宿主细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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4.发明授权Orthogonal translation components for the in vivo incorporation of unnatural amino acids 有权用于体内引入非天然氨基酸的正交翻译组分公开(公告)号：US08216804B2
公开(公告)日：2012-07-10
申请号：US11665083
申请日：2005-10-27
申请人： Peter G. Schultz , Jianming Xie , Huaqiang Zeng
发明人： Peter G. Schultz , Jianming Xie , Huaqiang Zeng
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入到在细菌宿主细胞如大肠杆菌或真核宿主如酵母细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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