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1.发明申请Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids 有权用于体内并入非天然氨基酸的正交翻译组分公开(公告)号：US20080233611A1
公开(公告)日：2008-09-25
申请号：US11665083
申请日：2005-10-27
申请人： Peter G. Schultz , Lital Alfonta , Jonathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng
发明人： Peter G. Schultz , Lital Alfonta , Jonathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入到在细菌宿主细胞如大肠杆菌或真核宿主如酵母细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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2.发明申请Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids 审中-公开用于体内并入非天然氨基酸的正交翻译组分公开(公告)号：US20130244245A1
公开(公告)日：2013-09-19
申请号：US13492296
申请日：2012-06-08
申请人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
发明人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入在诸如大肠杆菌或真核宿主如酵母细胞中的细胞宿主细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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3.发明授权Orthogonal translation components for the in vivo incorporation of unnatural amino acids 有权用于体内引入非天然氨基酸的正交翻译组分公开(公告)号：US09102932B2
公开(公告)日：2015-08-11
申请号：US13492296
申请日：2012-06-08
申请人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
发明人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入在诸如大肠杆菌或真核宿主如酵母细胞中的细胞宿主细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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公开(公告)号：US07807411B2
公开(公告)日：2010-10-05
申请号：US11805247
申请日：2007-05-21
申请人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
发明人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
IPC分类号： C12P21/00
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将香豆素非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸的蛋白质的方法和相关翻译系统。
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公开(公告)号：US08192952B2
公开(公告)日：2012-06-05
申请号：US12227383
申请日：2007-05-21
申请人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
发明人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将香豆素非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸的蛋白质的方法和相关翻译系统。
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公开(公告)号：US20090298119A1
公开(公告)日：2009-12-03
申请号：US12227383
申请日：2007-05-21
申请人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
发明人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将香豆素非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸的蛋白质的方法和相关翻译系统。
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公开(公告)号：US20120329162A1
公开(公告)日：2012-12-27
申请号：US13460174
申请日：2012-04-30
申请人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
发明人： Jiangyun Wang , Jianming Xie , Peter G. Schultz
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将香豆素非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸的蛋白质的方法和相关翻译系统。
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公开(公告)号：US20080044886A1
公开(公告)日：2008-02-21
申请号：US11805247
申请日：2007-05-21
申请人： Jiangyun Wang , Jianming Xie , Peter Schultz
发明人： Jiangyun Wang , Jianming Xie , Peter Schultz
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将香豆素非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸的蛋白质的方法和相关翻译系统。
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9.发明授权Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine 有权含有非天然氨基酸苯基硒代半胱氨酸的蛋白质的遗传程序表达公开(公告)号：US08217145B2
公开(公告)日：2012-07-10
申请号：US12225261
申请日：2007-03-13
申请人： Jiangyun Wang , Peter G. Schultz
发明人： Jiangyun Wang , Peter G. Schultz
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid phenylselenocysteine and translation systems. The invention further provides methods for producing modified proteins (e.g., lipidated proteins) through targeted modification of the phenylselenocysteine residue in a protein.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸苯硒代半胱氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交氨酰-tRNA合成酶，编码新合成酶分子的多核苷酸，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸苯基硒半胱氨酸的蛋白质的翻译方法和翻译系统。 本发明还提供了通过蛋白质中的苯基硒代半胱氨酸残基的靶向修饰产生修饰的蛋白质（例如，脂质化蛋白质）的方法。
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公开(公告)号：US20090209000A1
公开(公告)日：2009-08-20
申请号：US12225261
申请日：2007-03-13
申请人： Jiangyun Wang , Peter G. Schultz
发明人： Jiangyun Wang , Peter G. Schultz
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid phenylselenocysteine and translation systems. The invention further provides methods for producing modified proteins (e.g., lipidated proteins) through targeted modification of the phenylselenocysteine residue in a protein.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸苯硒代半胱氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交氨酰-tRNA合成酶，编码新合成酶分子的多核苷酸，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸苯基硒半胱氨酸的蛋白质的翻译方法和翻译系统。 本发明还提供了通过蛋白质中的苯基硒代半胱氨酸残基的靶向修饰产生修饰的蛋白质（例如，脂质化蛋白质）的方法。
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