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    Cell therapy for limiting overzealous inflammatory reactions in tissue healing
    5.
    发明授权
    Cell therapy for limiting overzealous inflammatory reactions in tissue healing 有权
    细胞疗法限制组织愈合过程中的过度炎症反应

    公开(公告)号：US09220813B2

    公开(公告)日：2015-12-29

    申请号：US13031431

    申请日：2011-02-21

    申请人： Mark C. Poznansky ,  Nicolas A. F. Chronos

    发明人： Mark C. Poznansky ,  Nicolas A. F. Chronos

    IPC分类号： C12N5/0781 ,  A61L31/00 ,  A61K35/17 ,  A61L15/40 ,  A61L27/38

    CPC分类号： A61L31/005 ,  A61K35/17 ,  A61L15/40 ,  A61L27/3804 ,  A61L27/3839

    摘要： Cells of the B cell lineage including pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, and some mature B cells, and/or cells of the T cell lineage, especially those with helper or regulatory function, most preferably autologous to the recipient, can be transplanted into damaged tissue to enhance recovery following injury. In a preferred embodiment, the cells are selected based on those cells which appear at the site of injury a few days after injury, such as macrophages, lymphocytes, which accelerate clean up and repair of the injured site and to mitigate the overzealous inflammatory response, presumably by inhibiting the inflammatory cells such as neutrophils and signals released thereby immediately following injury.

    摘要翻译： B细胞系的细胞包括前B细胞，前B细胞，前B细胞，未成熟B细胞和一些成熟B细胞，和/或T细胞谱系细胞，和/或T细胞谱系的细胞，特别是那些具有辅助或调节 功能，最优选自体接受者，可以移植到受损组织中以增强损伤后的恢复。 在优选的实施方案中，细胞是基于出现在损伤后几天的损伤部位的细胞，例如巨噬细胞，淋巴细胞，其加速对受伤部位的清理和修复并减轻过度炎症反应， 大概是通过抑制炎性细胞如嗜中性粒细胞和由此而迅速释放的信号。