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公开(公告)号：US20050142541A1
公开(公告)日：2005-06-30
申请号：US11021949
申请日：2004-12-23
申请人： Peter Lu , Jonathan Garman , Michael Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter Lu , Jonathan Garman , Michael Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
IPC分类号： A61K39/12 , C07K16/08 , C12Q1/70 , G01N33/574
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US20070128699A1
公开(公告)日：2007-06-07
申请号：US11650455
申请日：2007-01-05
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US20120141502A1
公开(公告)日：2012-06-07
申请号：US13265332
申请日：2010-04-20
申请人： Eric Dixon , Rainer Blaesius , Stephen Simkins , Steven L. Knapp , George Brough , Karen Lenz , Johannes Schweizer , Peter Lu , David Garman , Jon Silver , Charles Mahoney , Chamorro Somoza Diaz-Sarmiento
发明人： Eric Dixon , Rainer Blaesius , Stephen Simkins , Steven L. Knapp , George Brough , Karen Lenz , Johannes Schweizer , Peter Lu , David Garman , Jon Silver , Charles Mahoney , Chamorro Somoza Diaz-Sarmiento
IPC分类号： A61K39/395 , A61P31/20 , C40B30/04 , C12Q1/70 , C40B40/10
CPC分类号： G01N33/5748 , C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/76 , G01N33/56983 , G01N2333/025 , G01N2469/10
摘要： The subject invention provides an antibody composition for detecting E6 protein of at least one HPV strain in a sample. The subject antibodies may be used to detect oncogenic HPV E6 proteins in a sample, and the antibodies find use in a variety of diagnostic and therapeutic applications, including methods of diagnosing and treating cancer. Kits for performing the subject methods and containing the subject antibodies are also provided. Also disclosed in the present invention is a method of generating an antibody that specifically binds to amino-terminus of E6 proteins of at least two HPV strains.
摘要翻译： 本发明提供了用于检测样品中至少一种HPV病毒株的E6蛋白的抗体组合物。 受试抗体可用于检测样品中的致癌HPV E6蛋白，并且抗体可用于多种诊断和治疗应用，包括诊断和治疗癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。 本发明还公开了产生特异性结合至少两种HPV病毒株的E6蛋白的氨基末端的抗体的方法。
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公开(公告)号：US20120164629A1
公开(公告)日：2012-06-28
申请号：US13364954
申请日：2012-02-02
申请人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US20100209904A1
公开(公告)日：2010-08-19
申请号：US12660613
申请日：2010-03-01
申请人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
IPC分类号： C12Q1/70
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US20090047660A1
公开(公告)日：2009-02-19
申请号：US12156013
申请日：2008-05-28
申请人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US20070099199A1
公开(公告)日：2007-05-03
申请号：US11403141
申请日：2006-04-11
申请人： Peter Lu , Christoph Bagowski , Johannes Schweizer , Chamorro Diaz-Sarmiento , Jonathan Garman , Michael Belmares
发明人： Peter Lu , Christoph Bagowski , Johannes Schweizer , Chamorro Diaz-Sarmiento , Jonathan Garman , Michael Belmares
CPC分类号： C07K14/005 , A61K38/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02
摘要： The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.
摘要翻译： 本发明提供了用于治疗病原体感染，特别是人乳头瘤病毒感染的方法和组合物。 具体地，本发明提供了一种筛选方法，其涉及确定候选试剂对来自HPV的致癌菌株的E6蛋白与含有来自细胞蛋白MAGI-1的特定PDZ结构域的氨基酸序列的多肽的结合的影响 。 本发明提供了通过调节与MAGI-1的相互作用来治疗与病原体蛋白表达相关的疾病的方法，以及在这些方法中有用的许多分离的肽。 还提供了用于执行主题方法的套件。
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公开(公告)号：US20070020717A1
公开(公告)日：2007-01-25
申请号：US11426282
申请日：2006-06-23
申请人： Michael Belmares , Jonathan Garman , Peter Lu
发明人： Michael Belmares , Jonathan Garman , Peter Lu
IPC分类号： C12Q1/26
CPC分类号： G01N33/6896 , C12Q1/26 , G01N33/88 , G01N2500/00
摘要： The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1, TIP-1, MAST2, PSD95, or SHANK. The assays may be done in a cell-free environment or in a cellular environment, particularly using a neuronal cell. The invention finds use in a variety of therapeutic applications, including for identifying agents for use in treating cancer, pain, inflammation and neuronal conditions caused by acute insult, e.g., stroke.
摘要翻译： 本发明提供了一种用于确定测试试剂是否是COX调节剂的测定法。 一般来说，测定包括：测定测试试剂是否调节含PDZ的多肽与含COX PL的多肽的结合。 含PDZ的多肽可以含有MAGI1，TIP-1，MAST2，PSD95或SHANK的PDZ结构域的PDZ结构域。 测定可以在无细胞环境或细胞环境中进行，特别是使用神经元细胞。 本发明可用于各种治疗应用，包括用于鉴定用于治疗由急性损伤（例如中风）引起的癌症，疼痛，炎症和神经元病症的药剂。
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公开(公告)号：US20060148711A1
公开(公告)日：2006-07-06
申请号：US10714537
申请日：2003-11-14
申请人： Peter Lu , Jonathan Garman , Michael Belmares
发明人： Peter Lu , Jonathan Garman , Michael Belmares
CPC分类号： C07K5/081 , C07K5/1016 , C07K5/1021 , C07K14/47 , C07K14/705 , C07K2319/00
摘要： Inhibitors that disrupt binding between a PDZ protein and cognate ligands such as N-methyl-D-aspartate (NMDA) receptors that are involved in various neurological disorders are provided. Pharmaceutical compositions containing such inhibitors and their use in treating neurological diseases such as stroke and ischemia are also disclosed. Screening methods to identify additional inhibitors of specific protein ligand interactions with PDZ proteins are also described.
摘要翻译： 提供了破坏参与各种神经系统疾病的PDZ蛋白和类同体配体如N-甲基-D-天冬氨酸（NMDA）受体之间的结合的抑制剂。 还公开了含有这些抑制剂的药物组合物及其在治疗神经系统疾病如中风和缺血中的用途。 还描述了鉴定与PDZ蛋白特异性蛋白质配体相互作用的其它抑制剂的筛选方法。
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公开(公告)号：US20050255460A1
公开(公告)日：2005-11-17
申请号：US11053076
申请日：2005-02-07
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/42 , C12Q1/48 , C12Q1/70 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/68
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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