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14 条记录 (耗时 0.038 秒)

    Detection of influenza virus
    3.
    发明申请
    Detection of influenza virus 有权
    检测流感病毒

    公开(公告)号：US20070224594A1

    公开(公告)日：2007-09-27

    申请号：US11698798

    申请日：2007-01-26

    申请人： Peter Lu ,  Michael Belmares ,  Johannes Schweizer ,  Jon Silver

    发明人： Peter Lu ,  Michael Belmares ,  Johannes Schweizer ,  Jon Silver

    IPC分类号： C12Q1/70

    CPC分类号： G01N33/56983 ,  G01N2333/11 ,  G01N2500/02 ,  Y02A50/53 ,  Y02A50/60

    摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.

    摘要翻译： 本申请描述了用于检测甲型和（或）乙型流感和/或区分病原性和季节性流感A亚型的方法。 这些优选形式中的许多使用泛特异性抗体（即，与流感类型内的全部或至少多个菌株反应）以检测A型流感和/或B型流感和PDZ结构域与甲型流感病毒的特异性抗体的存在 区分致病性和季节性流感A亚型。

    DETECTION OF INFLUENZA VIRUS
    7.
    发明申请
    DETECTION OF INFLUENZA VIRUS 审中-公开

    公开(公告)号：US20100092944A1

    公开(公告)日：2010-04-15

    申请号：US12543079

    申请日：2009-08-18

    申请人： Peter Lu ,  Michael Belmares

    发明人： Peter Lu ,  Michael Belmares

    IPC分类号： C12Q1/70

    CPC分类号： G01N33/56983 ,  G01N2333/11 ,  G01N2500/02 ,  Y02A50/53 ,  Y02A50/60

    摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.

    METHODS AND COMPOSITIONS FOR MODULATING COX
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR MODULATING COX 失效
    调节COX的方法和组合物

    公开(公告)号：US20070020717A1

    公开(公告)日：2007-01-25

    申请号：US11426282

    申请日：2006-06-23

    申请人： Michael Belmares ,  Jonathan Garman ,  Peter Lu

    发明人： Michael Belmares ,  Jonathan Garman ,  Peter Lu

    IPC分类号： C12Q1/26

    CPC分类号： G01N33/6896 ,  C12Q1/26 ,  G01N33/88 ,  G01N2500/00

    摘要： The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1, TIP-1, MAST2, PSD95, or SHANK. The assays may be done in a cell-free environment or in a cellular environment, particularly using a neuronal cell. The invention finds use in a variety of therapeutic applications, including for identifying agents for use in treating cancer, pain, inflammation and neuronal conditions caused by acute insult, e.g., stroke.

    摘要翻译： 本发明提供了一种用于确定测试试剂是否是COX调节剂的测定法。 一般来说，测定包括：测定测试试剂是否调节含PDZ的多肽与含COX PL的多肽的结合。 含PDZ的多肽可以含有MAGI1，TIP-1，MAST2，PSD95或SHANK的PDZ结构域的PDZ结构域。 测定可以在无细胞环境或细胞环境中进行，特别是使用神经元细胞。 本发明可用于各种治疗应用，包括用于鉴定用于治疗由急性损伤（例如中风）引起的癌症，疼痛，炎症和神经元病症的药剂。

    Molecular interactions in neurons
    9.
    发明申请
    Molecular interactions in neurons 审中-公开
    神经元中的分子相互作用

    公开(公告)号：US20060148711A1

    公开(公告)日：2006-07-06

    申请号：US10714537

    申请日：2003-11-14

    申请人： Peter Lu ,  Jonathan Garman ,  Michael Belmares

    发明人： Peter Lu ,  Jonathan Garman ,  Michael Belmares

    IPC分类号： A61K38/10 ,  A61K38/08 ,  A61K38/06 ,  C07K7/08 ,  C07K7/06

    CPC分类号： C07K5/081 ,  C07K5/1016 ,  C07K5/1021 ,  C07K14/47 ,  C07K14/705 ,  C07K2319/00

    摘要： Inhibitors that disrupt binding between a PDZ protein and cognate ligands such as N-methyl-D-aspartate (NMDA) receptors that are involved in various neurological disorders are provided. Pharmaceutical compositions containing such inhibitors and their use in treating neurological diseases such as stroke and ischemia are also disclosed. Screening methods to identify additional inhibitors of specific protein ligand interactions with PDZ proteins are also described.

    摘要翻译： 提供了破坏参与各种神经系统疾病的PDZ蛋白和类同体配体如N-甲基-D-天冬氨酸（NMDA）受体之间的结合的抑制剂。 还公开了含有这些抑制剂的药物组合物及其在治疗神经系统疾病如中风和缺血中的用途。 还描述了鉴定与PDZ蛋白特异性蛋白质配体相互作用的其它抑制剂的筛选方法。

    Methods and compositions for diagnosis and treatment of influenza
    10.
    发明申请
    Methods and compositions for diagnosis and treatment of influenza 有权
    用于流感诊断和治疗的方法和组成

    公开(公告)号：US20070161078A1

    公开(公告)日：2007-07-12

    申请号：US11481411

    申请日：2006-07-03

    申请人： Peter Lu ,  Joshua Rabinowitz ,  Michael Belmares

    发明人： Peter Lu ,  Joshua Rabinowitz ,  Michael Belmares

    IPC分类号： C12Q1/68 ,  C12P21/06

    CPC分类号： A61K38/07 ,  A61K38/08 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/02

    摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.

    摘要翻译： 本发明提供用于确定样品中流感病毒的存在和量的方法和组合物，其包括流感A的高风险菌株。还提供了确定受试者是否感染流感病毒的方法以及类型和 流感病毒株。 所述方法包括使来自受试者的样品与PDZ多肽（PDZ）和/或PDZ配体（PL）接触并确定在PDZ和PL之间是否发生结合相互作用。 还提供了用于鉴定抗病毒剂的测定法，以及使用该组合物改变流感病毒感染细胞中PDZ与PL结合的方法。