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    Fluid collection and monitoring device
    1.
    发明授权
    Fluid collection and monitoring device 有权
    流体收集和监测装置

    公开(公告)号：US06679841B2

    公开(公告)日：2004-01-20

    申请号：US09880948

    申请日：2001-06-15

    申请人： Peter M. Bojan ,  Timothy P. Henning ,  Neil W. Loomis ,  Mark R. Pope ,  Jonathan A. Eppstein

    发明人： Peter M. Bojan ,  Timothy P. Henning ,  Neil W. Loomis ,  Mark R. Pope ,  Jonathan A. Eppstein

    IPC分类号： A61B500

    CPC分类号： A61B5/14865 ,  A61B5/14514 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/157 ,  A61B5/441 ,  A61B10/0045 ,  A61B18/20 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2018/1807 ,  A61B2562/0295 ,  Y10T436/2575

    摘要： An article capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article. Preferably, the article is also capable of measuring the amount of analyte in the interstitial fluid. The article can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid. In one preferred embodiment, the article is a multiple-layer element comprising: (1) a layer that is capable of being placed in contact with the skin of a patient; (2) a layer that is coated over the skin-contacting layer; (3) a layer, substantially coplanar with the overcoat layer, that is capable of transporting interstitial fluid by means of chemically aided wicking; (4) a layer, overlying the interstitial fluid transporting layer, that is capable of being placed in contact with a meter, said layer having an opening therein through which light can be transmitted; (5) a layer, disposed on the surface of the meter-contacting layer that faces the skin-contyacting layer, that is capable of detecting the presence of analyte or measuring the amount of analyte in the fluid. In order to use the multiple-layer element, light from a source of light is transmitted through the opening in the multiple-layer material to be absorbed at a light-absorbing target on the skin-contacting layer. This light transfers energy to the target, and this transferred energy causes an opening to form in the skin-contacting layer and an opening to form in the stratum corneum. Interstitial fluid exudes from the opening in the stratum corneum and contacts the interstitial fluid transporting layer. The interstitial fluid then moves along or through the interstitial fluid transporting layer to the detecting layer.

    摘要翻译： 能够收集间质液并检测该液体中的分析物的物品以及该物品的使用方法。 优选地，制品还能够测量间质液中的分析物的量。 该制品可以与包含用于确定间质液中分析物的量的适当检测元件的仪表结合使用。 在一个优选实施例中，制品是多层元件，包括：（1）能够与患者皮肤接触的层;（2）涂覆在皮肤接触层上的层; （3）与外涂层基本上共面的层，其能够通过化学辅助芯吸输送组织液;（4）层叠在间质流体输送层上的层，其能够被置于与 所述层具有开口，通过所述开口可以传输光;（5）设置在所述仪表接触层的面向所述皮肤对接层的表面上的层，其能够检测分析物的存在或测量 流体中的分析物的量。为了使用多层元件，来自光源的光透过多层材料中的开口，以在皮肤接触层上的吸光目标处被吸收 。 这种光将能量转移到目标物上，并且这种转移的能量导致在皮肤接触层中形成开口并在角质层中形成开口。 间质液从角质层中的开口渗出并与组织液输送层接触。 间隙液然后沿着或穿过间隙液输送层移动到检测层。

    Multiple mechanical microporation of skin or mucosa
    6.
    发明授权
    Multiple mechanical microporation of skin or mucosa 有权
    皮肤或粘膜多机械微孔化

    公开(公告)号：US06183434B2

    公开(公告)日：2001-02-06

    申请号：US09202207

    申请日：1999-06-14

    申请人： Jonathan A. Eppstein

    发明人： Jonathan A. Eppstein

    IPC分类号： A61B1720

    CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0053

    摘要： A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.

    摘要翻译： 使用选定深度和任选的一种或多种声波，电磁，机械和热能的微孔来描述增强生物膜（包括动物的皮肤或粘膜或植物外层）渗透性的渗透性的方法 和化学增强剂。 完成微孔以在生物膜中形成选定深度的微孔，并且该位置与渗透物接触。 可以将另外的渗透增强措施应用于该部位，以增强通过微孔以及生物体内靶向组织的渗透物通向微生物的通量。

    Microporation of human skin for monitoring the concentration of an analyte
    7.
    发明授权
    Microporation of human skin for monitoring the concentration of an analyte 失效
    用于监测分析物浓度的人皮肤的微孔

    公开(公告)号：US5885211A

    公开(公告)日：1999-03-23

    申请号：US776863

    申请日：1997-09-05

    申请人： Jonathan A. Eppstein ,  Michael R. Hatch ,  Difei Yang

    发明人： Jonathan A. Eppstein ,  Michael R. Hatch ,  Difei Yang

    IPC分类号： A61B5/00 ,  A61B10/00 ,  A61B17/00 ,  A61B17/32 ,  A61B18/20 ,  A61K41/00 ,  A61K49/22 ,  A61M37/00

    CPC分类号： A61B5/681 ,  A61B10/0045 ,  A61B5/14514 ,  A61B5/1486 ,  A61K41/0047 ,  A61K49/22 ,  A61M37/0092 ,  A61B17/3203 ,  A61B18/20 ,  A61B18/203 ,  A61B2017/00172 ,  A61B2017/00761 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2562/0295 ,  A61M2037/0007

    摘要： A method of enhancing the permeability of the skin to an analyte for diagnostic purposes or to a drug for therapeutic purposes is described utilizing microporation and optionally sonic energy and a chemical enhancer. If selected, the sonic energy may be modulated by means of frequency modulation, amplitude modulation, phase modulation, and/or combinations thereof. Microporation is accomplished by (a) ablating the stratum corneum by localized rapid heating of water such that such water is vaporized, thus eroding the cells; (b) puncturing the stratum corneum with a micro-lancet calibrated to form a micropore of up to about 1000 .mu.m in diameter; (c) ablating the stratum corneum by focusing a tightly focused beam of sonic energy onto the stratum corneum; (d) hydraulically puncturing the stratum corneum with a high pressure jet of fluid to form a micropore of up to about 1000 .mu.m in diameter, or (e) puncturing the stratum corneum with short pulses of electricity to form a micropore of up to about 1000 .mu.m in diameter. A dye with an absorption maximum matched to the wavelength of a pulsed light source can be absorbed into the stratum corneum to concentrate the energy of the pulsed light source and aid in ablation of the stratum corneum. Alternatively, a hot wire can be caused to contact the stratum corneum.

    摘要翻译： PCT No.PCT / US96 / 13865 Sec。 371日期：1997年9月5日 102（e）1997年9月5日PCT PCT 1996年8月29日PCT公布。 公开号WO97 / 07734 日期1997年3月6日利用微孔和任选的声能和化学增强剂描述了增强皮肤对诊断目的的分析物或用于治疗目的的药物的渗透性的方法。 如果选择，则可以通过频率调制，幅度调制，相位调制和/或其组合来调制声能。 通过（a）通过局部快速加热水来消融角质层，使得这种水被蒸发，从而侵蚀细胞来实现微孔化; （b）用经过校准的微型刺血针刺穿角质层以形成直径约达1000微米的微孔; （c）通过将紧密聚焦的声能束聚焦在角质层上来消融角质层; （d）用高压喷射流体水力刺穿角质层以形成直径达约1000μm的微孔，或（e）以短脉冲电穿刺角质层以形成高达约 直径1000亩。 具有与脉冲光源的波长匹配的吸收最大值的染料可以被吸收到角质层中以集中脉冲光源的能量并有助于消除角质层。 或者，可以使热丝接触角质层。

    Light beam generation, and focusing and redirecting device
    9.
    发明授权
    Light beam generation, and focusing and redirecting device 有权
    光束产生，聚焦和重定向装置

    公开(公告)号：US06951411B1

    公开(公告)日：2005-10-04

    申请号：US10018913

    申请日：2000-06-15

    申请人： Krishna S. Kumar ,  Danny F. Lincoln ,  Jonathan A. Eppstein ,  Michael R. Hatch

    发明人： Krishna S. Kumar ,  Danny F. Lincoln ,  Jonathan A. Eppstein ,  Michael R. Hatch

    IPC分类号： A61B17/00 ,  A61B18/20 ,  F21V14/06

    CPC分类号： A61B18/20 ,  A61B2017/00765 ,  A61B2018/20351

    摘要： An improved light beam generation and focusing device (15, 50) has a light source (16, 51) constructed and arranged to emit at least one beam of light (20), and a lens assembly (17, 19, 56) constructed and arranged to focus the at least one beam of light on a surface plane. The device is constructed and arranged to sequentially direct the at least one beam of light to at least two spaced locations (21, 21′) on the surface plane. The lens assembly comprises a collimating lens (17), and a spaced focusing lens (19).

    摘要翻译： 改进的光束产生和聚焦装置（15,50）具有构造和布置成发射至少一个光束（20）的光源（16,51），以及构成并构造的透镜组件（17,19,56） 布置成将至少一束光聚焦在表面上。 该装置被构造和布置成将至少一束光顺序地引导到表面上的至少两个间隔开的位置（21,21'）。 透镜组件包括准直透镜（17）和间隔开的聚焦透镜（19）。

    Integrated poration, harvesting and analysis device, and method therefor
    10.
    发明授权
    Integrated poration, harvesting and analysis device, and method therefor 失效
    综合栽培，收获和分析装置及其方法

    公开(公告)号：US06922578B2

    公开(公告)日：2005-07-26

    申请号：US10671006

    申请日：2003-09-25

    申请人： Jonathan A. Eppstein ,  Mark A. Samuels ,  Michael R. Hatch

    发明人： Jonathan A. Eppstein ,  Mark A. Samuels ,  Michael R. Hatch

    IPC分类号： A61M37/00 ,  A61B5/00 ,  A61B10/00 ,  A61B17/00 ,  A61K41/00 ,  A61K45/00 ,  A61B5/05

    CPC分类号： A61B5/15134 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/15136 ,  A61B5/157 ,  A61B2010/008 ,  A61B2017/00172 ,  A61B2562/12 ,  A61K41/0047

    摘要： An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.

    摘要翻译： 用于生物组织的装配，从组织收获生物流体和生物流体分析的综合装置。 该装置包括具有电或光学加热的探针的组织​​接触层，以加热和传导热量到组织以形成至少一个开口，例如从孔开始收集生物流体的微孔，以及响应生物学的检测层 流体以提供生物流体的特征的指示，例如间质液中分析物的浓度。 在其中探针包括设计用于将光敏材料（例如染料或颜料）均匀施用于组织例如层状物的光敏组合物的实施方案中。 在一个实施方案中，光敏组合物包含与载体（例如粘合剂或油墨）组合的光敏材料，并将所得组合物施加到基材上，例如惰性聚合物基材以形成 光敏组装。 在另一个实施方案中，光敏组合物包含掺入成膜聚合物材料中的光敏材料。