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1.发明授权公开(公告)号：US06922578B2
公开(公告)日：2005-07-26
申请号：US10671006
申请日：2003-09-25
CPC分类号： A61B5/15134 , A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150229 , A61B5/150358 , A61B5/15136 , A61B5/157 , A61B2010/008 , A61B2017/00172 , A61B2562/12 , A61K41/0047
摘要： An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.
摘要翻译： 用于生物组织的装配，从组织收获生物流体和生物流体分析的综合装置。 该装置包括具有电或光学加热的探针的组织接触层，以加热和传导热量到组织以形成至少一个开口，例如从孔开始收集生物流体的微孔，以及响应生物学的检测层 流体以提供生物流体的特征的指示，例如间质液中分析物的浓度。 在其中探针包括设计用于将光敏材料（例如染料或颜料）均匀施用于组织例如层状物的光敏组合物的实施方案中。 在一个实施方案中，光敏组合物包含与载体（例如粘合剂或油墨）组合的光敏材料，并将所得组合物施加到基材上，例如惰性聚合物基材以形成 光敏组装。 在另一个实施方案中，光敏组合物包含掺入成膜聚合物材料中的光敏材料。
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公开(公告)号：US07384396B2
公开(公告)日：2008-06-10
申请号：US10435221
申请日：2003-05-08
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/00 , A61B5/0002 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/150862 , A61B5/150969 , A61B5/150984 , A61B5/15134 , A61B5/155 , A61B5/157 , A61B10/0045 , A61B2010/008
摘要： A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.
摘要翻译： 一种用于从生物体提取生物流体并连续监测其特征的系统和方法。 该系统包括适于定位在生物体的生物膜的表面上或周围的组织界面装置以及耦合到组织界面装置的监测和控制单元。 组织接口装置包括定位在流体的流动路径中的传感器，用于在生物流体从形成在生物膜中的一个或多个人造开口流出时持续感测生物流体的特性。 传感器产生代表其的传感器信号。 监视器和控制单元以电或光学方式读取传感器，以连续的方式获得生物流体特性的浓度，例如特定分析物的浓度。
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3.发明授权Apparatus and methods for measuring characteristics of biological tissues and similar materials 失效用于测量生物组织和类似材料特性的装置和方法
公开(公告)号：US5582168A
公开(公告)日：1996-12-10
申请号：US7584
申请日：1993-01-22
CPC分类号： A61B5/1455 , A61B3/1173 , A61B5/14532
摘要： Apparatus and methods for characterizing biological tissues and other turbid media with normalization that serves to compensate for the effects of scattering, reflectance, and absorption are disclosed.
摘要翻译： 公开了用于表征用于补偿散射，反射和吸收的影响的归一化的生物组织和其他混浊介质的装置和方法。
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4.发明授权Apparatus and methods for quantitatively measuring molecular changes in the ocular lens 失效用于定量测量OCARAR镜中分子变化的方法和方法
公开(公告)号：US5203328A
公开(公告)日：1993-04-20
申请号：US731533
申请日：1991-07-17
CPC分类号： A61B5/1455 , A61B3/1173 , A61B5/14532
摘要： Apparatus and methods for noninvasively diagnosing diabetes mellitus, the prediabetic condition, and cataracts in the human (or other) body are disclosed. Diagnoses are made by illuminating ocular lens tissue with a narrow-band light source at a selected wavelength, detecting the backscattered radiation intensity at the peak of the fluorescent response, and normalizing the detected value with the intensity of its Rayleigh component. Measurements provided in this manner can be used as improved indicators of the presence or absence of certain diseases or conditions.
摘要翻译： 公开了用于非侵入性诊断糖尿病，前列腺疾病和人（或其他）身体中的白内障的装置和方法。 通过用选定波长的窄带光源照射眼透镜组织来进行诊断，检测在荧光响应的峰值处的反向散射辐射强度，并用其瑞利分量的强度归一化检测值。 以这种方式提供的测量可以用作某些疾病或病症的存在或不存在的改进指标。
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公开(公告)号：US5860421A
公开(公告)日：1999-01-19
申请号：US587949
申请日：1996-01-17
CPC分类号： A61B5/1495 , A61B5/0059 , A61B2560/0233
摘要： A disposable calibration device is used to calibrate a measurement system which transmits radiation or acoustic waves to a material or tissue in order to effect measurements. The disposable calibration device includes a structure with a window through which the radiation or acoustic waves can be transmitted, as well as a removable calibration target arranged on the window and capable of returning a portion of the radiation or acoustic waves for calibrating the measurement system. The removable calibration target can be peeled from window to allow a measurement to be made on the material or tissue. Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the measuring system.
摘要翻译： 一次性校准装置用于校准将辐射或声波传输到材料或组织以测量的测量系统。 一次性校准装置包括具有透射辐射或声波的窗口的结构以及布置在窗口上并且能够返回一部分辐射或声波以便校准测量系统的可移除校准目标。 可移除的校准目标可以从窗口剥离，以便在材料或组织上进行测量。 一旦测量完成，可以丢弃一次性校准装置，并且可以在测量系统上插入新的校准装置。
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公开(公告)号：US06882873B2
公开(公告)日：2005-04-19
申请号：US10303832
申请日：2002-11-26
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B2560/0233 , A61B2562/247
摘要： A system and method embodying the invention can be used to detect a characteristic or condition of a patient. A method embodying the invention may include the steps of illuminating a portion of a skin of the patient with light, detecting a frequency spectrum of light scattered from the skin, determining, from first and second portions of the spectrum, a first parameter indicative of a blood content of the skin and a second parameter indicative of a melanin content of the skin, determining, from a third portion of the spectrum, a third parameter indicative of an uncorrected bilirubin concentration, and calculating a corrected bilirubin concentration based on the first, second and third parameters.
摘要翻译： 体现本发明的系统和方法可用于检测患者的特征或状况。 体现本发明的方法可以包括以下步骤：用光照射患者皮肤的一部分，检测从皮肤散射的光的频谱，从频谱的第一和第二部分确定指示一个 皮肤的血液含量和指示皮肤黑色素含量的第二参数，从光谱的第三部分确定指示未校正的胆红素浓度的第三参数，以及基于第一，第二 和第三个参数。
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公开(公告)号：US06226541B1
公开(公告)日：2001-05-01
申请号：US08992576
申请日：1997-12-17
IPC分类号： A61B500
CPC分类号： A61B5/0059 , A61B5/0075 , A61B5/1495 , A61B2560/0233 , G01J5/02 , G01J5/021 , G01J5/04 , G01J5/048 , G01J5/522 , G01N21/278
摘要： A disposable calibration device is used to calibrate a measurement system which transmits radiation or acoustic waves to a material or tissue in order to effect measurements. The disposable calibration device includes a structure with a window through which the radiation or acoustic waves can be transmitted, as well as a removable calibration target arranged on the window and capable of returning a portion of the radiation or acoustic waves for calibrating the measurement system. The removable calibration target can be peeled from a window to allow a measurement to be made on the material or tissue. Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the measuring system.
摘要翻译： 一次性校准装置用于校准将辐射或声波传输到材料或组织以测量的测量系统。 一次性校准装置包括具有透射辐射或声波的窗口的结构以及布置在窗口上并且能够返回一部分辐射或声波以便校准测量系统的可移除校准目标。 可移除的校准目标可以从窗口剥离，以允许在材料或组织上进行测量。 一旦测量完成，可以丢弃一次性校准装置，并且可以在测量系统上插入新的校准装置。
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公开(公告)号：US5792049A
公开(公告)日：1998-08-11
申请号：US906969
申请日：1997-08-06
CPC分类号： G01N21/278 , A61B5/0059 , A61B5/1495 , G01J5/02 , G01J5/021 , G01J5/04 , G01J5/048 , G01J5/522 , A61B2560/0233
摘要： A disposable calibration device is used to calibrate a spectroscopic measurement system which transmits radiation to a material or tissue in order to effect measurements such as bilirubin measurements. The disposable calibration device includes a structure with a window through which radiation can be transmitted, as well as a removable calibration target arranged on the window and capable of returning a portion of the radiation for calibrating the spectrometer system. The removable calibration target can be peeled of the window to allow a measurement to be made on the material or tissue. Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the spectroscopic system.
摘要翻译： 一次性校准装置用于校准将辐射传输到材料或组织的光谱测量系统，以便进行诸如胆红素测量的测量。 一次性校准装置包括具有可以透射辐射的窗口的结构以及布置在窗口上并且能够返回一部分辐射以用于校准光谱仪系统的可移除校准目标。 可拆卸的校准目标物可以从窗户上剥离，以便对材料或组织进行测量。 一旦测量完成，可以丢弃一次性校准装置，并且可以在光谱系统上插入新的校准装置。
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公开(公告)号：US6045502A
公开(公告)日：2000-04-04
申请号：US904766
申请日：1997-08-01
CPC分类号： A61B5/0059 , A61B5/0075 , A61B5/1495 , G01J5/02 , G01J5/021 , G01J5/04 , G01J5/048 , G01J5/522 , G01N21/278 , A61B2560/0233
摘要： A system and method for calibrating a measurement instrument prior to making a measurement on a material or tissue includes utilizing a removable calibration device to calibrate the instrument, then removing a target portion of the calibration device so that a measurement may be performed. The calibration device may include an index matching agent, such as a gel, that is to be interposed between the patient's skin and an output end of the measuring instrument. A method embodying the invention may include making a bilirubin concentration measurement on a skin of a patient by measuring the amplitude of light reflected from the patient's skin at first and second wavelengths indicative of a blood content of the patient's skin, and measuring the amplitude of reflected light at a third wavelength indicative of an uncorrected bilirubin concentration, then calculating a corrected bilirubin concentration based on the three measurements. The method may also include taking measurements at fourth and fifth wavelengths indicative of a melanin content of the patient's skin, and calculating the bilirubin concentration based on the fourth and fifth measurements.
摘要翻译： 用于在对材料或组织进行测量之前校准测量仪器的系统和方法包括利用可移除的校准装置校准所述仪器，然后移除所述校准装置的目标部分，使得可以执行测量。 校准装置可以包括要置于患者皮肤和测量仪器的输出端之间的折射率匹配剂，例如凝胶。 体现本发明的方法可以包括通过测量从患者皮肤反射的光的幅度来指示患者皮肤的血液含量的第一和第二波长来测量患者皮肤上的胆红素浓度，并测量反射的 指示未校正的胆红素浓度的第三波长的光，然后基于三次测量计算校正的胆红素浓度。 该方法还可以包括在指示患者皮肤的黑色素含量的第四和第五波长处进行测量，以及基于第四和第五测量来计算胆红素浓度。
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10.发明授权Integrated alignment devices, system, and methods for efficient fluid extraction, substance delivery and other applications 有权用于高效流体萃取，物质输送和其他应用的集成对齐装置，系统和方法公开(公告)号：US06925317B1
公开(公告)日：2005-08-02
申请号：US10018001
申请日：2000-06-12
申请人： Mark A. Samuels , Krishna S. Kumar , Garrett T. Robinson , J. David Farquhar , Allison Minton , Diedre Williams , Michael R. Hatch , Alan M. Smith , Teresa Woods , Mark Vreeke
发明人： Mark A. Samuels , Krishna S. Kumar , Garrett T. Robinson , J. David Farquhar , Allison Minton , Diedre Williams , Michael R. Hatch , Alan M. Smith , Teresa Woods , Mark Vreeke
CPC分类号： A61B5/6833 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150343 , A61B5/150748 , A61B5/150961 , A61B5/150969 , A61B5/15111 , A61B5/15134 , A61B5/157 , A61B10/0045 , A61B2017/00477 , A61B2017/00482
摘要： An alignment device and related systems and methods for aligning at least one apparatus with respect to a surface of a tissue. The alignment device comprises a tissue interface member suitable for positioning on the surface of the tissue and mating with the apparatus to maintain alignment of the apparatus during an operation of the apparatus. The alignment device is useful to align various apparatus that are part of a continuous analyte monitoring system.
摘要翻译： 对准装置以及用于相对于组织表面对准至少一个装置的相关系统和方法。 对准装置包括适于定位在组织的表面上并与装置配合的组织接口构件，以在装置的操作期间保持设备的对准。 对准装置可用于对准作为连续分析物监测系统的一部分的各种装置。
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