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1.发明申请PEPTIDYLARGININE DEIMINASE AND USES THEREOF IN THE PRODUCTION OF CITRULLINATED PROTEINS AND PEPTIDES 审中-公开肽衍生物及其在生产蛋白质和蛋白质中的用途公开(公告)号：US20090297689A1
公开(公告)日：2009-12-03
申请号：US12306469
申请日：2007-06-25
IPC分类号： A23J1/00 , C12P21/06 , C12N9/14 , C12N5/10 , C12N15/63 , C07K5/08 , C07K7/06 , C07K5/10 , C07K14/00 , C07H21/04
CPC分类号： C12N9/78 , A23L33/00 , A23L33/18 , A23L33/185 , A23L33/19 , C12Y305/03015
摘要： The present invention relates to a protein, peptide or protein hydrolysate wherein the molar ratio of citrulline and arginine residues, being part of protein or peptide, is at least 0.15, preferably at least 0.30, more preferably at least 0.5, still more preferably at least 1.0, even still more preferably 2.0 and most preferably at least 4.
摘要翻译： 本发明涉及蛋白质，肽或蛋白质水解产物，其中作为蛋白质或肽的一部分的瓜氨酸和精氨酸残基的摩尔比为至少0.15，优选至少0.30，更优选至少0.5，还更优选至少为 1.0，甚至更优选2.0，最优选至少4。
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公开(公告)号：US09011948B2
公开(公告)日：2015-04-21
申请号：US12094541
申请日：2006-11-28
申请人： Petrus Jacobus Theodorus Dekker , Luppo Edens , Maximiliaan Peter Marie De Swaaf , Albertus Alard Van Dijk
发明人： Petrus Jacobus Theodorus Dekker , Luppo Edens , Maximiliaan Peter Marie De Swaaf , Albertus Alard Van Dijk
CPC分类号： A23C9/127 , A23C9/1206 , A23C19/0328 , C12N9/16 , C12N9/2402 , C12N9/2468 , C12N9/2471 , C12N9/62 , C12Y301/06001 , C12Y302/01023 , C12Y302/01108
摘要： Process for producing a dairy product by adding a lactase to a dairy product which contains lactose, the lactase added having less than 40 units arylsulfatase activity per NLU of lactase activity.
摘要翻译： 通过向含有乳糖的乳制品中加入乳糖酶来生产乳制品的方法，所述乳糖酶加入的乳糖酶活性为每NLU少于40个芳基硫酸酯酶活性。
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公开(公告)号：US20110165306A1
公开(公告)日：2011-07-07
申请号：US12993174
申请日：2009-05-28
IPC分类号： A23L2/00 , C12N9/58 , C07H21/04 , C12N15/63 , C12N15/80 , C12N5/10 , C12N1/00 , C12P21/06 , C07K2/00 , A23J1/00 , A23K1/00
CPC分类号： C12N9/58 , A23K20/147 , A23L33/18
摘要： A polypeptide having proline-specific protease activity which comprises the amino acid sequence set out in SEQ ID NO: 3 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1 and/or SEQ ID NO: 2, or a variant thereof or a fragment of either thereof. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
摘要翻译： 具有脯氨酸特异性蛋白酶活性的多肽，其包含SEQ ID NO：3所示的氨基酸序列或由SEQ ID NO：1和/或SEQ ID NO：2的核苷酸序列编码的氨基酸序列，或变体 或其任何一个片段。 本发明还涉及在工业过程中使用该多肽的方法。 本发明还包括用适合于生产这些蛋白质的根据本发明的多核苷酸转化的细胞。
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公开(公告)号：US20080286412A1
公开(公告)日：2008-11-20
申请号：US12094541
申请日：2006-11-28
申请人： Petrus Jacobus Theodorus Dekker , Luppo Edens , Maximiliaan Peter Marie Swaaf , Albertus Alard Van Dijk
发明人： Petrus Jacobus Theodorus Dekker , Luppo Edens , Maximiliaan Peter Marie Swaaf , Albertus Alard Van Dijk
CPC分类号： A23C9/127 , A23C9/1206 , A23C19/0328 , C12N9/16 , C12N9/2402 , C12N9/2468 , C12N9/2471 , C12N9/62 , C12Y301/06001 , C12Y302/01023 , C12Y302/01108
摘要： The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
摘要翻译： 本发明描述了细胞内产生的乳糖酶，其包含每NLU乳糖酶活性少于40个芳基硫酸酯酶活性。 本发明还提供了一种方法，其包括用酶制剂处理底物，其中所述酶制剂基本上不含芳基硫酸酯酶。
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公开(公告)号：US07972808B2
公开(公告)日：2011-07-05
申请号：US12039973
申请日：2008-02-29
CPC分类号： C12N9/48
摘要： The present invention describes a protein hydrolysate which is rich in tripeptides whereby the tripeptides are rich in proline at one end of the peptide.
摘要翻译： 本发明描述了一种富含三肽的蛋白质水解产物，其中三肽在肽的一端富含脯氨酸。
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6.发明授权Protein hydrolysates enriched in peptides having a carboxy terminal proline residue 有权富含具有羧基末端脯氨酸残基的肽的蛋白质水解产物公开(公告)号：US07309595B2
公开(公告)日：2007-12-18
申请号：US10450185
申请日：2001-12-06
申请人： Petrus Jacobus Theodorus Dekker , Luppo Edens , Robertus Antonius Mijndert Van Der Hoeven , Linda De Lange
发明人： Petrus Jacobus Theodorus Dekker , Luppo Edens , Robertus Antonius Mijndert Van Der Hoeven , Linda De Lange
IPC分类号： C12N9/48
CPC分类号： G01N33/573 , A23J3/16 , A23J3/343 , A23J3/344 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C12H1/003 , C12Q1/37 , G01N33/56961 , G01N2333/38
摘要： The present invention provides An isolated polypeptide which has proline specific endoprotease activity, selected from the group consisting of:(a) a polypeptide which has an amino acid sequence which has at least 40% amino acid sequence identity with amino acids 1 to 526 of SEQ ID NO:2 or a fragment thereof;(b) a polypeptide which is encoded by a polynucleotide which hybridizes under low stringency conditions with (i) the nucleic acid sequence of SEQ ID NO:1 or a fragment thereof which is at least 80% or 90% identical over 60, preferably over 100 nucleotides, more preferably at least 90% identical over 200 nucleotides, or (ii) a nucleic acid sequence complementary to the nucleic acid sequence of SEQ ID NO:1.
摘要翻译： 本发明提供了具有脯氨酸特异性内切蛋白酶活性的分离多肽，其选自：（a）多肽，其具有与SEQ ID NO：1至526的氨基酸至少具有40％氨基酸序列同一性的氨基酸序列 或其片段;（b）由在低严格条件下与（i）SEQ ID NO：1的核酸序列或其片段至少80％的杂交的多核苷酸编码的多肽， 或超过200个核苷酸的90％以上，优选超过100个核苷酸，更优选至少90％相同，或（ii）与SEQ ID NO：1的核酸序列互补的核酸序列。
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7.发明授权公开(公告)号：US08802088B2
公开(公告)日：2014-08-12
申请号：US12989869
申请日：2009-04-27
IPC分类号： A61K38/48 , C12Q1/34 , C12Q1/37 , A61K38/01 , A61K38/05 , A61K38/06 , A61K38/00 , C07K14/00 , C07K16/02 , A61K47/34 , C12Q1/06 , G01N33/68 , A61K38/47 , A61K38/02 , A61P25/00
CPC分类号： A61K38/47 , A23J3/341 , A23L33/18 , A61K31/405 , C12P21/06 , C12Y302/01017
摘要： The present invention relates to a composition which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.
摘要翻译： 本发明涉及一种组合物，其包含色氨酸，由此存在色氨酸的10至90％，优选20至80％的游离色氨酸或肽结合的色氨酸，并且存在10至90％，优选20至80％的色氨酸存在 作为多肽结合的色氨酸。
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公开(公告)号：US20080113896A1
公开(公告)日：2008-05-15
申请号：US11793390
申请日：2005-12-21
CPC分类号： C12P21/06 , A23J3/344 , A23L33/11 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/00 , A23V2200/3262 , A23V2200/332 , A23V2200/326 , A23V2250/54246 , A23V2250/2136 , A23V2250/7052 , A23V2250/706 , A23V2250/7056
摘要： A process to produce IPP and VPP from a protein source that comprises the -I-P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P- sequence present in the protein source is converted into the peptide VPP, which comprises the use of a proline specific endoprotease and an amino-peptidase preferably in a single enzymatic step.
摘要翻译： 从其蛋白质序列中包含-IPP-和-VPP-序列的蛋白质源产生IPP和VPP的过程，并且其中存在于蛋白质源中的-IPP-序列的至少40％被转化为肽IPP，并且在 存在于蛋白质源中的-VPP序列的至少40％被转化为肽VPP，其包括优选在单个酶促步骤中使用脯氨酸特异性内切蛋白酶和氨基肽酶。
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公开(公告)号：US07323327B2
公开(公告)日：2008-01-29
申请号：US10469204
申请日：2002-02-22
申请人： Luppo Edens , Albertus Van Dijk , Philipp Krubasik , Kaj Albermann , Alexander Stock , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Wilk Von Gustedt , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
发明人： Luppo Edens , Albertus Van Dijk , Philipp Krubasik , Kaj Albermann , Alexander Stock , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Wilk Von Gustedt , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
CPC分类号： A23J3/16 , A23J3/343 , A23J3/344 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C07K2319/00 , C12H1/003 , C12N9/62 , C12Q1/37 , G01N33/56961 , G01N33/573 , G01N2333/38
摘要： The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.
摘要翻译： 本发明涉及新鉴定的编码从黑曲霉获得的新型蛋白酶的基因序列。 本发明的特征在于新基因的全长基因序列，其cDNA序列以及全长功能蛋白及其片段。 本发明还涉及在工业过程中使用这些酶的方法和诊断真菌感染的方法。 本发明还包括用根据本发明的DNA转化的细胞和其中根据本发明的蛋白酶被遗传修饰以增强或降低其活性和/或表达水平的细胞。
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公开(公告)号：US20050064403A1
公开(公告)日：2005-03-24
申请号：US10469204
申请日：2002-02-22
申请人： Luppo Edens , Dijk Alard , Philipp Krubasik , Kaj Albermann , Stock Alexander , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Gustedt Wilk , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
发明人： Luppo Edens , Dijk Alard , Philipp Krubasik , Kaj Albermann , Stock Alexander , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Gustedt Wilk , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
IPC分类号： A23J3/16 , A23J3/34 , A23L1/29 , A23L1/305 , A23L2/02 , A23L2/84 , C07K16/40 , C12H1/00 , C12N9/62 , C12N15/57 , C12N15/63 , C12Q1/37 , G01N33/569 , G01N33/573 , C12Q1/68 , C07H21/04 , C12N9/64
CPC分类号： A23J3/16 , A23J3/343 , A23J3/344 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C07K2319/00 , C12H1/003 , C12N9/62 , C12Q1/37 , G01N33/56961 , G01N33/573 , G01N2333/38
摘要： The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.
摘要翻译： 本发明涉及新鉴定的编码从黑曲霉获得的新型蛋白酶的基因序列。 本发明的特征在于新基因的全长基因序列，其cDNA序列以及全长功能蛋白及其片段。 本发明还涉及在工业过程中使用这些酶的方法和诊断真菌感染的方法。 本发明还包括用根据本发明的DNA转化的细胞和其中根据本发明的蛋白酶被遗传修饰以增强或降低其活性和/或表达水平的细胞。
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