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    Acylaminothiazole derivatives, their preparation and their therapeutic use
    1.
    发明授权
    Acylaminothiazole derivatives, their preparation and their therapeutic use 失效
    酰氨基噻唑衍生物，其制备及其治疗用途

    公开(公告)号：US07563903B2

    公开(公告)日：2009-07-21

    申请号：US11186507

    申请日：2005-07-21

    申请人： Pierre Despeyroux ,  Daniel Frehel ,  Bruno Schoentjes ,  Viviane Van Dorsselaer

    发明人： Pierre Despeyroux ,  Daniel Frehel ,  Bruno Schoentjes ,  Viviane Van Dorsselaer

    IPC分类号： A61K31/426 ,  C07D277/46

    CPC分类号： C07D417/12 ,  C07D277/46

    摘要： Compound corresponding to the general formula (I): in which, X represents an oxygen or sulphur atom; R1 represents a C1-10 alkyl group optionally substituted, a C3-7 cycloalkyl, thienyl, pyridinyl or pyrimidinyl group; the thienyl groups being optionally substituted; the phenyl group being optionally substituted; R2 represents a C1-6 alkyl group optionally substituted, a C3-7 cycloalkyl, piperidinyl, phenyl or pyridinyl group; the C3-7 cycloalkyl and piperidinyl groups being optionally substituted; the phenyl and pyridinyl groups being optionally substituted; R3 represents a hydrogen atom or a C1-6 alkyl group optionally substituted with a C3-7 cycloalkyl group; R4 represents a hydrogen atom or a C1-6 alkyl group; R5 and R5′ represent, independently of each other, a hydrogen or halogen atom, a hydroxyl or C1-3 alkyl group; or R5 and R5′ form together an oxo or oxime group such as: where R7 represents a hydrogen atom or a C1-3 alkyl; n represents an integer ranging from 0 to 3; and R6 represents, independently of each other when n=2 or 3, a hydrogen or halogen atom, a hydroxyl, C1-3 alkyl, C1-3 alkoxy, C1-3 fluoroalkyl or C1-3 fluoroalkoxy group; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. therapeutic application.

    摘要翻译： 对应于通式（I）的化合物：其中X表示氧或硫原子; R 1表示任选取代的C 1-10烷基，C 3-7环烷基，噻吩基，吡啶基或嘧啶基; 噻吩基任选被取代; 苯基任选被取代; R 2表示任选取代的C 1-6烷基，C 3-7环烷基，哌啶基，苯基或吡啶基; C3-7环烷基和哌啶基任选被取代; 苯基和吡啶基任选被取代; R3表示氢原子或任选被C 3-7环烷基取代的C 1-6烷基; R4表示氢原子或C1-6烷基; R5和R5'彼此独立地表示氢或卤素原子，羟基或C1-3烷基; 或R 5和R 5'一起形成氧基或肟基，例如：其中R 7表示氢原子或C 1-3烷基; n表示0〜3的整数， 当n = 2或3时，R 6表示独立地为氢或卤原子，羟基，C 1-3烷基，C 1-3烷氧基，C 1-3氟烷基或C 1-3氟烷氧基; 以碱的形式，与酸的加成盐，水合物或溶剂合物的治疗应用。

    Acylaminothiazole derivatives, their preparation and their therapeutic use
    2.
    发明申请
    Acylaminothiazole derivatives, their preparation and their therapeutic use 失效
    酰氨基噻唑衍生物，其制备及其治疗用途

    公开(公告)号：US20060052426A1

    公开(公告)日：2006-03-09

    申请号：US11186507

    申请日：2005-07-21

    申请人： Pierre Despeyroux ,  Daniel Frehel ,  Bruno Schoentjes ,  Viviane Van Dorsselaer

    发明人： Pierre Despeyroux ,  Daniel Frehel ,  Bruno Schoentjes ,  Viviane Van Dorsselaer

    IPC分类号： C07D277/18 ,  A61K31/426

    CPC分类号： C07D417/12 ,  C07D277/46

    摘要： Compound corresponding to the general formula (I): in which, X represents an oxygen or sulphur atom; R1 represents a C1-10 alkyl group optionally substituted, a C3-7 cycloalkyl, thienyl, pyridinyl or pyrimidinyl group; the thienyl groups being optionally substituted; the phenyl group being optionally substituted; R2 represents a C1-6 alkyl group optionally substituted, a C3-7 cycloalkyl, piperidinyl, phenyl or pyridinyl group; the C3-7 cycloalkyl and piperidinyl groups being optionally substituted; the phenyl and pyridinyl groups being optionally substituted; R3 represents a hydrogen atom or a C1-6 alkyl group optionally substituted with a C3-7 cycloalkyl group; R4 represents a hydrogen atom or a C1-6 alkyl group; R5 and R5′ represent, independently of each other, a hydrogen or halogen atom, a hydroxyl or C1-3 alkyl group; or R5 and R5′ form together an oxo or oxime group such as: where R7 represents a hydrogen atom or a C1-3 alkyl; n represents an integer ranging from 0 to 3; and R6 represents, independently of each other when n=2 or 3, a hydrogen or halogen atom, a hydroxyl, C1-3 alkyl, C1-3 alkoxy, C1-3 fluoroalkyl or C1-3 fluoroalkoxy group; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. therapeutic application.

    摘要翻译： 对应于通式（I）的化合物：

    Acylaminothiazole derivatives, their preparation and therapeutic use
    7.
    发明授权
    Acylaminothiazole derivatives, their preparation and therapeutic use 有权
    酰氨基噻唑衍生物，其制备和治疗用途

    公开(公告)号：US07288659B2

    公开(公告)日：2007-10-30

    申请号：US10485837

    申请日：2002-08-05

    申请人： Paul De Cointet ,  Pierre Despeyroux ,  Daniel Frehel ,  Chantal Guenet ,  Corinne Heckel ,  Jean-Pierre Maffrand ,  Rebecca Pruss

    发明人： Paul De Cointet ,  Pierre Despeyroux ,  Daniel Frehel ,  Chantal Guenet ,  Corinne Heckel ,  Jean-Pierre Maffrand ,  Rebecca Pruss

    IPC分类号： C07D277/46

    CPC分类号： C07D417/12 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46

    摘要： The invention concerns a compound of general formula (I), wherein: X represents an oxygen or sulphur atom; R1 represents, independently of each other when n=2 or 3, a halogen atom, a hydroxy, a C1-C3 alkyl, a C1-C3 alkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy; R2 represents a C1-C6 alkyl group optionally substituted, a C3-C7 cycloalkyl, piperidinyl or phenyl group, the C3-C7 cycloalkyl, piperidinyl or phenyl groups being optionally substituted; R3 represents a hydrogen atom or a C1-C6 alkyl group optionally substituted; R4 represents a hydrogen atom or a C1-C4 alkyl group; and R5 and R5′ represent, independently of each other, a hydrogen atom, a hydroxy, a halogen atom, a C1-C3 alkyl group, or R5 and R5′ form together an oxo group; R6 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl, a C1-C3 alkoxy, a trifluoromethyl, or a trifluoromethoxy; in the form of a base, addition to an acid, hydrate or solvate. The invention is applicable in therapy

    摘要翻译： 本发明涉及通式（I）的化合物，其中：X表示氧或硫原子; R 1表示n = 2或3时彼此独立地表示卤素原子，羟基，C 1 -C 3烷基 C 1 -C 3烷氧基，三氟甲基，三氟甲氧基或亚甲二氧基; R 2表示任选取代的C 1 -C 6烷基，C 3 -C 6烷基， 7个环烷基，哌啶基或苯基，C 3 -C 7环烷基，哌啶基或苯基任选被取代; R 3表示任选取代的氢原子或C 1 -C 6 -C 6烷基; R 4表示氢原子或C 1 -C 4烷基; R 5和R 5'彼此独立地表示氢原子，羟基，卤素原子，C 1〜 C 3烷基或R 5和R 5'一起形成氧代基; R 6表示氢原子，卤素原子，C 1 -C 3烷基，C 1〜 -C 3烷氧基，三氟甲基或三氟甲氧基; 以碱的形式加入酸，水合物或溶剂化物。 本发明适用于治疗