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1.发明授权Use of prebiotics, preferably glucooligosaccharide, for the prevention of the onset of type II diabetes 有权使用益生元，优选葡糖低聚糖，用于预防II型糖尿病的发病公开(公告)号：US07618951B2
公开(公告)日：2009-11-17
申请号：US10527819
申请日：2003-09-12
申请人： Pierre Monsan , Philippe Valet , Magali Remaud-Simeon , Jean-Sebastien Saulnier-Blache , Remy Burcelin
发明人： Pierre Monsan , Philippe Valet , Magali Remaud-Simeon , Jean-Sebastien Saulnier-Blache , Remy Burcelin
IPC分类号： A61K31/715 , A61K31/702 , A61K31/70 , A61K31/7016
CPC分类号： A61K31/716 , A23L29/35 , A23L33/10 , A23V2002/00 , A61K31/702 , A61K2300/00 , A23V2250/606 , A23V2250/61 , A23V2250/616 , A23V2250/628 , A23V2250/5114 , A23V2250/28
摘要： The invention relates to the use of prebiotics for the preparation of food or pharmaceutical compositions which are intended for the treatment and/or prevention of hyperglycaemic syndromes and, in particular, for the treatment of Type II diabetes and/or the prevention of the onset of Type II diabetes in patients with a predisposition to developing the type of diabetes. The invention also relates to the food and pharmaceutical compositions containing the prebiotics.
摘要翻译： 本发明涉及益生元用于制备用于治疗和/或预防高血糖综合征的食物或药物组合物的用途，特别是用于治疗II型糖尿病和/或预防 患有糖尿病发病倾向的II型糖尿病患者。 本发明还涉及含有益生元的食品和药物组合物。
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公开(公告)号：US20060100172A1
公开(公告)日：2006-05-11
申请号：US10527819
申请日：2003-09-12
IPC分类号： A61K31/715 , A61K47/00
CPC分类号： A61K31/716 , A23L29/35 , A23L33/10 , A23V2002/00 , A61K31/702 , A61K2300/00 , A23V2250/606 , A23V2250/61 , A23V2250/616 , A23V2250/628 , A23V2250/5114 , A23V2250/28
摘要： The invention relates to the use of prebiotics for the preparation of food or pharmaceutical compositions which are intended for the treatment and/or prevention of hyperglycaemic syndromes and, in particular, for the treatment of Type II diabetes and/or the prevention of the onset of Type II diabetes in patients with a predisposition to developing the type of diabetes. The invention also relates to the food and pharmaceutical compositions containing the prebiotics.
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公开(公告)号：US20060127328A1
公开(公告)日：2006-06-15
申请号：US11011702
申请日：2004-12-14
CPC分类号： C12P19/04 , C12N9/1051 , C12Y204/0114
摘要： Nucleic acid sequences of truncated or mutated alternansucrases, vectors containing these nucleic acids sequences, host cells transformed with the nucleic acid sequences encoding truncated or mutated alternansucrases are provided. Furthermore, a process to recombinantly alternansucrase with a high level of expression, while retaining the enzymatic activity is described.
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4.发明授权Fully active alternansucrases partially deleted in its carboxy-terminal and amino-terminal domains and mutants thereof 有权在其羧基末端和氨基末端结构域及其突变体中部分缺失的完全活性的交替蔗糖酶公开(公告)号：US07524645B2
公开(公告)日：2009-04-28
申请号：US11011702
申请日：2004-12-14
CPC分类号： C12P19/04 , C12N9/1051 , C12Y204/0114
摘要： Nucleic acid sequences of truncated or mutated alternansucrases, vectors containing these nucleic acids sequences, host cells transformed with the nucleic acid sequences encoding truncated or mutated alternansucrases are provided. Furthermore, a process to recombinantly alternansucrase with a high level of expression, while retaining the enzymatic activity is described.
摘要翻译： 提供了截短或突变的交替蔗糖酶的核酸序列，含有这些核酸序列的载体，用编码截短或突变的交替蔗糖酶的核酸序列转化的宿主细胞。 此外，描述了具有高水平表达的重组交替蔗糖酶同时保留酶活性的方法。
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5.发明申请MUTANTS OF GLYCOSIDE HYDROLASES AND USES THEREOF FOR SYNTHESIZING COMPLEX OLIGOSACCHARIDES AND DISACCHARIDE INTERMEDIATES 审中-公开甘油三酯水解物及其用于合成复合寡糖和不对称中间体的用途公开(公告)号：US20110086767A1
公开(公告)日：2011-04-14
申请号：US12922108
申请日：2009-03-12
申请人： Laurence Mulard , Isabelle Andre , Elise Champion , Claire Moulis , Sandrine Morel , Pierre Monsan , Magali Remaud-Simeon , Karine Descroix
发明人： Laurence Mulard , Isabelle Andre , Elise Champion , Claire Moulis , Sandrine Morel , Pierre Monsan , Magali Remaud-Simeon , Karine Descroix
CPC分类号： C07H15/10 , C12N9/1051 , C12P19/16 , C12P19/18 , C12P19/26 , C12Y204/01004
摘要： Method for preparing the disaccharide α-D-glucopyranosyl-(1→4)-2-N-acetyl-2-deoxy-α-D-glucopyranoside, comprising the step of using a mutant of a wild type glycoside hydrolase.
摘要翻译： 制备二糖α-D-吡喃葡萄糖基 - （1→4）-2-N-乙酰基-2-脱氧-α-D-吡喃葡萄糖苷的方法，包括使用野生型糖苷水解酶突变体的步骤。
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6.发明申请MUTANTS OF GLYCOSIDE HYDROLASES AND USES THEREOF FOR SYNTHESIZING COMPLEX OLIGOSACCHARIDES AND DISACCHARIDE INTERMEDIATES 审中-公开甘油三酯水解物及其用于合成复合寡糖和不对称中间体的用途公开(公告)号：US20110144317A1
公开(公告)日：2011-06-16
申请号：US12922113
申请日：2009-03-12
申请人： Laurence Mulard , Isabelle Andre , Elise Champion , Claire Moulis , Sandrine Morel , Pierre Monsan , Magali Remaud-Simeon , Julien Boutet
发明人： Laurence Mulard , Isabelle Andre , Elise Champion , Claire Moulis , Sandrine Morel , Pierre Monsan , Magali Remaud-Simeon , Julien Boutet
IPC分类号： C12P19/12 , C12N9/10 , C12N9/24 , C07H21/00 , C12N15/63 , C12P19/26 , C07H15/04 , C07H13/02 , C07H9/04
CPC分类号： C12P19/16 , C12N9/1051 , C12N9/2402 , C12P19/18 , C12Y204/01004 , C12Y302/01048
摘要： Method for preparing the disaccharide [α-D-Gldp(1→3)]-α-L-Rhap-YR wherein Y is selected from —O— and —S— and R is selected from the group consisting of: C1-C6 alkyl, C1-C6 alkenyl, aryl, allyl, —CO-alkyl (C1-C6), —CO-alkenyl (C1-C6), —CO-aryl comprising the step of using a mutant of a wild type glycoside hydrolase.
摘要翻译： 制备二糖[α-D-Gldp（1→3）] -a-L-Rhap-YR的方法，其中Y选自-O-和-S-，R选自：C 1 -C 6 烷基，C 1 -C 6烯基，芳基，烯丙基，-CO-烷基（C 1 -C 6），-CO-烯基（C 1 -C 6），-CO-芳基，包括使用野生型糖苷水解酶突变体的步骤。
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7.发明申请Nucleic acid molecules coding for a dextran-saccharase catalysing the synthesis of dextran with alpha 1,2 osidic sidechains 有权编码葡聚糖糖基化酶的核酸分子，其催化葡聚糖与α1,2巯基侧链的合成公开(公告)号：US20060210510A1
公开(公告)日：2006-09-21
申请号：US10509024
申请日：2002-03-18
CPC分类号： C12N9/1051 , A61K38/00 , C12Y204/01005
摘要： The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with α(1→2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same.
摘要翻译： 本发明涉及具有糖基转移酶酶活性的分离多肽，其用于用α（1→2）侧链生产葡聚糖，其包含至少一个用于结合葡聚糖的区域和位于结合葡聚糖的区域之外的催化活性区域。 本发明还涉及编码所述酶的多核苷酸和含有其的载体。
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公开(公告)号：US20130273623A1
公开(公告)日：2013-10-17
申请号：US13882372
申请日：2011-10-27
申请人： Thomas Walther , Hélène Cordier , Christopher Topham , Isabelle Andre , Magali Remaud-Simeon , Robert Huet , Jean-Marie Francois
发明人： Thomas Walther , Hélène Cordier , Christopher Topham , Isabelle Andre , Magali Remaud-Simeon , Robert Huet , Jean-Marie Francois
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , C07F9/096 , C12N9/0006 , C12N9/0008 , C12N9/1217 , C12N15/70 , C12P7/40 , C12P9/00 , C12Y101/01 , C12Y102/01011 , C12Y102/01018 , C12Y207/02004
摘要： The present invention deals with a method of producing 2,4-dihydroxybutyric acid (2,4-DHB) by a synthetic pathway comprising the transformation of malate in 4-phospho-malate using a malate kinase, said 4-phospho-malate being transformed in malate-4-semialdehyde using a malate semialdehyde dehydrogenase and said malate-4-semialdehyde being transformed in 2,4-DHB using a DHB dehydrogenase.
摘要翻译： 本发明涉及一种通过合成途径生产2,4-二羟基丁酸（2,4-DHB）的方法，该方法包括使用苹果酸激酶在4-磷酸苹果酸中转化苹果酸，所述4-磷酸苹果酸酯被转化 在苹果酸4-半醛中使用苹果酸半醛脱氢酶，并且使用DHB脱氢酶在2,4-DHB中转化所述苹果酸4-半醛。
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9.发明授权Construction of new variants of dextransucrase DSR-S by genetic engineering 有权通过基因工程构建葡聚糖蔗糖酯酶DSR-S的新变体公开(公告)号：US07897373B2
公开(公告)日：2011-03-01
申请号：US12223744
申请日：2007-02-08
CPC分类号： C12N9/1051 , C07H3/06 , C07K2319/35 , C08B37/0021 , C12P19/04 , C12P19/08 , C12P19/12 , C12P19/18 , C12Y204/01005 , Y02P20/52
摘要： The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or their specificity in the synthesis of the α-1,6 bonds. The present invention relates to nucleic acid sequences of truncated or mutated dextransucrases, vectors containing the nucleic acid sequences and host cells transformed by sequences encoding truncated or mutated dextransucrases. In another aspect, the invention concerns a method for producing, in a recombinant manner, truncated or mutated dextransucrases which conserve their enzymatic activity or which conserve their specificity in the synthesis of α-1,6 bonds and can produce, from saccharose, dextrans with high molar mass and modified rheological properties compared with the properties of dextran obtained with the native enzyme and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and isomalto-oligosaccharides of the invention can be used namely as texturing agents or as prebiotics.
摘要翻译： 本发明涉及一种在保护酶活性或其合成α-1,6键的特异性的同时生产截短或突变的葡聚糖蔗糖酶的重组方法。 本发明涉及截短或突变的葡聚糖蔗糖酶的核酸序列，含有核酸序列的载体和由编码截短或突变的葡聚糖蔗糖酶的序列转化的宿主细胞。 另一方面，本发明涉及一种以重组方式生产截短或突变的葡聚糖蔗糖酯的方法，其保留其酶活性或在合成α-1,6键时保护其特异性，并可从蔗糖，葡萄糖， 与用天然酶和具有受控摩尔质量的异麦芽低聚糖和葡聚糖获得的葡聚糖的性质相比，具有高的摩尔质量和改进的流变学性质。 本发明的葡聚糖和异麦芽低聚糖可以用作变形剂或益生元。
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公开(公告)号：US09238829B2
公开(公告)日：2016-01-19
申请号：US13882372
申请日：2011-10-27
申请人： Thomas Walther , Helene Cordier , Christopher Topham , Isabelle Andre , Magali Remaud-Simeon , Robert Huet , Jean-Marie Francois
发明人： Thomas Walther , Helene Cordier , Christopher Topham , Isabelle Andre , Magali Remaud-Simeon , Robert Huet , Jean-Marie Francois
CPC分类号： C12P7/42 , C07F9/096 , C12N9/0006 , C12N9/0008 , C12N9/1217 , C12N15/70 , C12P7/40 , C12P9/00 , C12Y101/01 , C12Y102/01011 , C12Y102/01018 , C12Y207/02004
摘要： A method of producing 2,4-dihydroxybutyric acid (2,4-DHB) by a synthetic pathway that includes the transforming malate in 4-phospho-malate using a malate kinase, said 4-phospho-malate being transformed in malate-4-semialdehyde using a malate semialdehyde dehydrogenase and said malate-4-semialdehyde being transformed in 2,4-DHB using a DHB dehydrogenase.
摘要翻译： 一种通过合成途径生产2,4-二羟基丁酸（2,4-DHB）的方法，该方法包括使用苹果酸激酶在4-磷酸苹果酸中转化苹果酸，所述4-磷酸苹果酸酯转化为苹果酸4- 使用苹果酸半醛脱氢酶的半醛，并使用DHB脱氢酶在2,4-DHB中转化所述苹果酸4-半醛。
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