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公开(公告)号：US20170267803A1
公开(公告)日：2017-09-21
申请号：US15611426
申请日：2017-06-01
IPC分类号： C08G18/32 , C08G18/66 , C07C69/40 , C07C69/60 , C07C69/675 , C08L75/04 , C08G18/42 , C08G18/77 , A61L31/06 , C08G18/73 , A61L27/18 , C08G18/10
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula.(I)
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公开(公告)号：US09695268B2
公开(公告)日：2017-07-04
申请号：US14573733
申请日：2014-12-17
IPC分类号： C08G18/32 , C08G18/66 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/42 , C08G18/77 , C08G18/73
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula (I)
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公开(公告)号：US20150105530A1
公开(公告)日：2015-04-16
申请号：US14573733
申请日：2014-12-17
CPC分类号： C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要： The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula (I)
摘要翻译： 本发明涉及扩链剂，其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲（例如支架，用于组织工程的支架）中的用途。 扩链剂包括式（I）化合物，
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公开(公告)号：US09084827B2
公开(公告)日：2015-07-21
申请号：US14098831
申请日：2013-12-06
IPC分类号： A61K31/74 , A61K47/48 , A61L27/18 , A61L27/58 , C08G18/32 , C08G18/80 , A61L27/38 , A61L27/50 , A61F2/30
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
摘要翻译： 本发明涉及生物相容的，可生物降解的聚氨酯/尿素聚合物组合物，其能够在低发热下体内固化以形成适用于组织工程应用如骨和软骨修复中的支架的材料。 聚合物理想地是可流动和可注射的，并且可以支持活的生物组分以帮助愈合过程。 它们可以用于侵入性外科手术修复方法离体固化，或者替代地用于相对非侵入性的手术修复方法，例如通过关节镜。 本发明还涉及可用于制备聚合物组合物的预聚物，以及使用本发明的聚合物处理受损组织的方法。
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公开(公告)号：US20140099277A1
公开(公告)日：2014-04-10
申请号：US14098831
申请日：2013-12-06
IPC分类号： A61K47/48
CPC分类号： A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要： The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
摘要翻译： 本发明涉及生物相容的，可生物降解的聚氨酯/尿素聚合物组合物，其能够在低发热下体内固化以形成适用于组织工程应用如骨和软骨修复中的支架的材料。 聚合物理想地是可流动和可注射的，并且可以支持活的生物组分以帮助愈合过程。 它们可以用于侵入性外科手术修复方法离体固化，或者替代地用于相对非侵入性的手术修复方法，例如通过关节镜。 本发明还涉及可用于制备聚合物组合物的预聚物，以及使用本发明的聚合物处理受损组织的方法。
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公开(公告)号：US09540478B2
公开(公告)日：2017-01-10
申请号：US14685837
申请日：2015-04-14
IPC分类号： A61L27/18 , C08G18/34 , A61K31/785 , A61L31/10 , C08G18/32 , C08G18/42 , C08G18/66 , C08G18/77 , A61L27/38 , A61L27/54 , C09D175/06
CPC分类号： C08G18/348 , A61K31/785 , A61L27/18 , A61L27/3804 , A61L27/54 , A61L31/10 , A61L2300/412 , A61L2300/414 , C08G18/3206 , C08G18/3221 , C08G18/4277 , C08G18/6607 , C08G18/771 , C08G2230/00 , C09D175/06 , C08L75/04
摘要： This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.
摘要翻译： 本发明涉及包含异氰酸酯，多元醇和具有可水解连接基团的常规扩链剂和/或扩链剂的生物相容性，可生物降解的热塑性聚氨酯或聚氨酯/脲，以及其在组织工程和修复应用中的用途，特别是作为支架和支架涂层。
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