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公开(公告)号：US07045683B2
公开(公告)日：2006-05-16
申请号：US10120637
申请日：2002-04-11
申请人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
发明人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
CPC分类号： C12N9/0083 , A23D9/00 , A23K20/158 , A23L7/126 , A23L9/12 , A61K38/00 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “Δ4-desaturase”). In particular, Δ4-desaturase may be utilized, for example, in the conversion of adrenic acid to ω6-docosapentaenoic acid and in the conversion of ω3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译： 本发明涉及鉴定涉及碳4处多不饱和脂肪酸去饱和的基因（即“Δ4-去饱和酶”）。 特别地，可以使用Δ4-去饱和酶，例如，将肾上腺酸转化为ω6-二十二碳五烯酸，并将ω3-二十二碳五烯酸转化成二十二碳六烯酸。 通过使用酶产生的多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。
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公开(公告)号：US06677145B2
公开(公告)日：2004-01-13
申请号：US09903456
申请日：2001-07-11
IPC分类号： C12N910
CPC分类号： C12N9/1029 , A01K2217/05 , A23D9/00 , A23K20/158 , A61K8/361 , A61K8/606 , A61K8/64 , A61K31/202 , A61K38/00 , A61K2800/86 , A61Q19/00 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to &ohgr;3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, &ohgr;6-docosapentaenoic acid or &ohgr;3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译： 本发明涉及鉴定涉及多不饱和酸延伸的几种基因（即“延伸酶”）及其应用。 这些基因中至少有两个也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将γ-亚麻酸（GLA）转化为二亚麻酸（DGLA）和将AA转化为肾上腺素（ADA）或二十碳五烯酸（EPA）转化为ω-二十二碳五烯酸（DPA） 。 DGLA可用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω6-二十二碳五烯酸或ω3-二十二碳五烯酸，其可加入到药物组合物中，营养组合物 ，动物饲料，以及化妆品等其他产品。
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公开(公告)号：US07968692B2
公开(公告)日：2011-06-28
申请号：US12046857
申请日：2008-03-12
IPC分类号： C07H21/04
CPC分类号： A23D9/00 , A01K2217/05 , A23K20/158 , A61K8/361 , A61K8/606 , A61K8/64 , A61K31/202 , A61K38/00 , A61K2800/86 , A61Q19/00 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ω3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译： 本发明涉及多参与多不饱和脂肪酸（即“延伸酶”）延伸的几个基因的鉴定及其应用。 这些基因中至少有两个也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将亚麻酸（GLA）转化为二亚麻酸（DGLA）和将AA转化为肾上腺素（ADA）或二十碳五烯酸（EPA）转化为ω3-二十二碳五烯酸（DPA） 。 DGLA可用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω6-二十二碳五烯酸或ω3-二十二碳五烯酸，其可加入到药物组合物中，营养组合物 ，动物饲料，以及化妆品等其他产品。
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公开(公告)号：US20080176944A1
公开(公告)日：2008-07-24
申请号：US12046857
申请日：2008-03-12
IPC分类号： A61K31/201 , C12N15/54 , C07K14/00 , C12N5/10 , A01H5/00 , A01K67/027 , C12P7/64
CPC分类号： A23D9/00 , A01K2217/05 , A23K20/158 , A61K8/361 , A61K8/606 , A61K8/64 , A61K31/202 , A61K38/00 , A61K2800/86 , A61Q19/00 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ω3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译： 本发明涉及多参与多不饱和脂肪酸（即“延伸酶”）延伸的几个基因的鉴定及其应用。 这些基因中至少有两个也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将γ-亚麻酸（GLA）转化为二亚麻酸（DGLA）和将AA转化为肾上腺素（ADA）或二十碳五烯酸（EPA）转化为ω-二十二碳五烯酸（DPA） 。 DGLA可用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω6-二十二碳五烯酸或ω3-二十二碳五烯酸，其可加入到药物组合物中，营养组合物 ，动物饲料，以及化妆品等其他产品。
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公开(公告)号：US07205134B2
公开(公告)日：2007-04-17
申请号：US10913779
申请日：2004-08-06
申请人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
发明人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
CPC分类号： C12N9/0083 , A23D9/00 , A23K20/158 , A23L7/126 , A23L9/12 , A61K38/00 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “Δ4-desaturase”). In particular, Δ4-desaturase may be utilized, for example, in the conversion of adrenic acid to ω6-docosapentaenoic acid and in the conversion of ω3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
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公开(公告)号：US07067285B2
公开(公告)日：2006-06-27
申请号：US10054534
申请日：2002-01-22
申请人： Pradip Mukerji , Yung-Sheng Huang , Tapas Das , Jennifer Thurmond , Amanda Eun-Yeong Leonard , Suzette L. Pereira
发明人： Pradip Mukerji , Yung-Sheng Huang , Tapas Das , Jennifer Thurmond , Amanda Eun-Yeong Leonard , Suzette L. Pereira
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
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公开(公告)号：US07375205B2
公开(公告)日：2008-05-20
申请号：US10912446
申请日：2004-08-05
CPC分类号： A23D9/00 , A01K2217/05 , A23K20/158 , A61K8/361 , A61K8/606 , A61K8/64 , A61K31/202 , A61K38/00 , A61K2800/86 , A61Q19/00 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ω3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译： 本发明涉及多参与多不饱和脂肪酸（即“延伸酶”）延伸的几个基因的鉴定及其应用。 这些基因中至少有两个也参与单不饱和脂肪酸的延伸。 特别地，延长酶用于将γ-亚麻酸（GLA）转化为二亚麻酸（DGLA）和将AA转化为肾上腺素（ADA）或二十碳五烯酸（EPA）转化为ω-二十二碳五烯酸（DPA） 。 DGLA可用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω6-二十二碳五烯酸或ω3-二十二碳五烯酸，其可加入到药物组合物中，营养组合物 ，动物饲料，以及化妆品等其他产品。
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公开(公告)号：US07220897B2
公开(公告)日：2007-05-22
申请号：US10913271
申请日：2004-08-06
申请人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
发明人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
CPC分类号： C12N9/0083 , A23D9/00 , A23K20/158 , A23L7/126 , A23L9/12 , A61K38/00 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “Δ4-desaturase”). In particular, Δ4-desaturase may be utilized, for example, in the conversion of adrenic acid to ω6-docosapentaenoic acid and in the conversion of ω3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
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公开(公告)号：US07208297B2
公开(公告)日：2007-04-24
申请号：US10913226
申请日：2004-08-06
申请人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
发明人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Eun-Yeong Leonard , Suzette L. Pereira
CPC分类号： C12N9/0083 , A23D9/00 , A23K20/158 , A23L7/126 , A23L9/12 , A61K38/00 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “Δ4-desaturase”). In particular, Δ4-desaturase may be utilized, for example, in the conversion of adrenic acid to ω6-docosapentaenoic acid and in the conversion of ω3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译： 本发明涉及鉴定涉及碳4处多不饱和脂肪酸去饱和的基因（即“Δ4-去饱和酶”）。 特别地，可以使用Δ4-去饱和酶，例如，将肾上腺酸转化为ω6-二十二碳五烯酸，并将ω3-二十二碳五烯酸转化成二十二碳六烯酸。 通过使用酶产生的多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。
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公开(公告)号：US06432684B1
公开(公告)日：2002-08-13
申请号：US09227613
申请日：1999-01-08
IPC分类号： C12P740
CPC分类号： A61K8/361 , A01K2217/05 , A23D9/00 , A23K20/158 , A23L7/126 , A23L9/10 , A23L33/10 , A23L33/12 , A23L33/13 , A23L33/17 , A23L33/40 , A23V2002/00 , A61K8/67 , A61K31/202 , A61K38/00 , A61Q19/00 , C12N9/0083 , C12N15/81 , C12N15/8247 , C12P7/6427 , C12P7/6472 , A23V2250/19 , A23V2250/1882 , A23V2250/1862
摘要： The subject invention relates to the identification of a gene involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “human &Dgr;5-desaturase”) and to uses thereof. In particular, human &Dgr;5-desaturase may be utilized, for example, in the conversion of dihomo-&ggr;-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译： 本发明涉及鉴定参与碳5多不饱和脂肪酸（即“人类DELTA5-去饱和酶”）去饱和的基因及其用途。 特别地，人类DELTA5-去饱和酶可用于例如将dihomo-γ-亚麻酸（DGLA）转化为花生四烯酸（AA）和将20：4n-3转化成二十碳五烯酸（EPA）的方法。 由其制备的AA或多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。
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