公开(公告)号：US10080841B2

公开(公告)日：2018-09-25

申请号：US15591329

申请日：2017-05-10

Applicant: President and Fellows of Harvard College

Inventor： Andy H. Levine ,  Christoph Matthias Kanzler ,  Daniel Leo Miranda ,  Joseph Mooney ,  Huy Lam ,  John Osborne ,  Mustafa Karabas ,  Alan Dunne ,  James Niemi ,  Benjamin Matthews ,  Donald E. Ingber ,  Olivier Henry ,  Premananda Pai Indic

IPC: A61B5/08 ,  A61M5/172 ,  A61M5/20 ,  A61M5/142 ,  A61M37/00 ,  A61K31/137 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/113 ,  A61B5/00

CPC classification number: A61M5/1723 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0452 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/0826 ,  A61B5/113 ,  A61B5/1135 ,  A61B5/145 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/7264 ,  A61B5/7278 ,  A61K31/137 ,  A61M5/00 ,  A61M5/14248 ,  A61M5/20 ,  A61M5/2053 ,  A61M37/00 ,  A61M37/0015 ,  A61M2005/1726 ,  A61M2005/206 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/30 ,  A61M2230/50 ,  A61M2230/63 ,  A61M2230/65

Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.

公开(公告)号：US20180361062A1

公开(公告)日：2018-12-20

申请号：US16109517

申请日：2018-08-22

Applicant: President and Fellows of Harvard College

Inventor： Andy H. Levine ,  Christoph Matthias Kanzler ,  Aymeric Guy ,  Daniel Leo Miranda ,  Joseph Mooney ,  Adam Zapotok ,  Samuel Berry ,  Huy Lam ,  Jonathan Sabaté del Río ,  John Osborne ,  Mustafa Karabas ,  Alan Dunne ,  James Niemi ,  Benjamin Matthews ,  Donald E. Ingber ,  Olivier Henry ,  Premananda Pai Indic

IPC: A61M5/172 ,  A61M5/142 ,  A61B5/02 ,  A61B5/08 ,  A61B5/145 ,  A61B5/00 ,  A61K31/137 ,  A61M5/00 ,  A61M5/20 ,  A61M37/00 ,  A61B5/0452 ,  A61B5/113 ,  A61B5/1486

Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.

公开(公告)号：US20180333533A1

公开(公告)日：2018-11-22

申请号：US15971915

申请日：2018-05-04

Applicant: President and Fellows of Harvard College ,  The Children's Medical Center Corporation ,  University of Massachusetts Medical School

Inventor： Andy H. Levine ,  Cristoph Matthias Kanzler ,  Aymeric Guy ,  Daniel Leo Miranda ,  Joseph Mooney ,  Adam Zapotok ,  Samuel Berry ,  Huy Lam ,  Jonathan Sabaté del Río ,  John Osborne ,  Mustafa Karabas ,  Alan Dunne ,  James Niemi ,  Benjamin Matthews ,  Donald E. Ingber ,  Olivier Henry ,  Premananda Pai Indic

IPC: A61M5/158 ,  A61M5/142 ,  A61M5/145 ,  A61M5/172

CPC classification number: A61M5/158 ,  A61M5/14248 ,  A61M5/1454 ,  A61M5/1723 ,  A61M2005/14252 ,  A61M2005/1581 ,  A61M2005/1585 ,  A61M2205/0266 ,  A61M2205/3303

Abstract: An injector module includes a housing, a reservoir, a superelastic needle, and an actuator. The reservoir is positioned in the housing and stores epinephrine therein. The superelastic needle is positioned within the housing in a retracted position and is fluidly coupled with the reservoir. The superelastic needle has a gauge between eighteen and twenty-five. The actuator is configured to apply an actuator force on the superelastic needle such that the superelastic needle is moved from the retracted position to an injecting position where a tip of the superelastic needle protrudes from the housing between about fifteen millimeters and about thirty-five millimeters.

公开(公告)号：US20170239418A1

公开(公告)日：2017-08-24

申请号：US15591329

申请日：2017-05-10

Applicant: President and Fellows of Harvard College

Inventor： Andy H. Levine ,  Christoph Matthias Kanzler ,  Aymeric Guy ,  Daniel Leo Miranda ,  Joseph Mooney ,  Adam Zapotok ,  Samuel Berry ,  Huy Lam ,  Jonathan Sabaté del Río ,  John Osborne ,  Mustafa Karabas ,  Alan Dunne ,  James Niemi ,  Benjamin Matthews ,  Donald E. Ingber ,  Olivier Henry ,  Premananda Pai Indic

IPC: A61M5/172 ,  A61K31/137 ,  A61M37/00 ,  A61M5/20 ,  A61M5/142

CPC classification number: A61M5/1723 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0452 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/0826 ,  A61B5/113 ,  A61B5/1135 ,  A61B5/145 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/7264 ,  A61B5/7278 ,  A61K31/137 ,  A61M5/00 ,  A61M5/14248 ,  A61M5/20 ,  A61M5/2053 ,  A61M37/00 ,  A61M37/0015 ,  A61M2005/1726 ,  A61M2005/206 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/30 ,  A61M2230/50 ,  A61M2230/63 ,  A61M2230/65

Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.