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    CHARGED NUTRITIVE PROTEINS AND METHODS
    1.
    发明申请
    CHARGED NUTRITIVE PROTEINS AND METHODS 有权
    充足的营养蛋白和方法

    公开(公告)号：US20130296231A1

    公开(公告)日：2013-11-07

    申请号：US13836855

    申请日：2013-03-15

    申请人： Pronutria, Inc.

    发明人： David Arthur Berry ,  Brett Adam Boghigian ,  Nathaniel W. Silver ,  Geoffrey von Maltzahn

    IPC分类号： A23L1/305

    CPC分类号： C07K14/001 ,  A23J3/04 ,  A23L33/17 ,  A23L33/18 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/198 ,  A61K38/00 ,  A61K38/16 ,  C07K14/415 ,  C12N15/8251 ,  Y02A50/473 ,  A23V2200/316 ,  A23V2250/55 ,  A61K2300/00

    摘要： Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

    摘要翻译： 提供带电的营养蛋白质。 在一些实施方案中，营养蛋白质在pH7下的水溶解度至少为12.5g / L。在一些实施方案中，营养蛋白质在pH7下具有至少50g / L的水溶解度。在一些实施方案中，营养蛋白质的水溶解度为 在一些实施方案中，营养蛋白质包含以下中的至少一种：a）支链氨基酸残基与存在于营养蛋白中的总氨基酸残基的比例等于或大于 支链氨基酸残基与基准蛋白中存在的总氨基酸残基的比例; b）营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例等于或大于存在于基准蛋白中的亮氨酸残基与总氨基酸残基的比例; 和c）营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例等于或大于基本蛋白质中存在的必需氨基酸残基与总氨基酸残基的比例。 还提供编码蛋白质的核酸，制备蛋白质的重组微生物，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法等。

    Charged Nutritive Proteins and Methods
    5.
    发明申请
    Charged Nutritive Proteins and Methods 有权
    充电营养蛋白和方法

    公开(公告)号：US20140342978A1

    公开(公告)日：2014-11-20

    申请号：US14337563

    申请日：2014-07-22

    申请人： Pronutria, Inc.

    发明人： David Arthur Berry ,  Brett Adam Boghigian ,  Nathaniel W. Silver ,  Geoffrey von Maltzahn ,  Michael Hamill ,  Rajeev Chillakuru ,  John F. Kramarczyk

    IPC分类号： C07K14/00 ,  A23L1/305 ,  A61K38/16

    CPC分类号： C07K14/001 ,  A23J3/04 ,  A23L33/17 ,  A23L33/18 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/198 ,  A61K38/00 ,  A61K38/16 ,  C07K14/415 ,  C12N15/8251 ,  Y02A50/473 ,  A23V2200/316 ,  A23V2250/55 ,  A61K2300/00

    摘要： Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.

    摘要翻译： 提供带电的营养蛋白质。 在一些实施方案中，营养蛋白质在pH7下的水溶解度至少为12.5g / L。在一些实施方案中，营养蛋白质在pH7下具有至少50g / L的水溶解度。在一些实施方案中，营养蛋白质的水溶解度为 在一些实施方案中，营养蛋白质包含以下中的至少一种：a）支链氨基酸残基与存在于营养蛋白中的总氨基酸残基的比例等于或大于 支链氨基酸残基与基准蛋白中存在的总氨基酸残基的比例; b）营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例等于或大于存在于基准蛋白中的亮氨酸残基与总氨基酸残基的比例; 和c）营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例等于或大于基本蛋白质中存在的必需氨基酸残基与总氨基酸残基的比例。 还提供编码蛋白质的核酸，制备蛋白质的重组微生物，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法等。

    Nutritive fragments, proteins and methods
    7.
    发明授权
    Nutritive fragments, proteins and methods 有权

    公开(公告)号：US09598474B2

    公开(公告)日：2017-03-21

    申请号：US14374127

    申请日：2013-03-15

    申请人： Pronutria, Inc.

    发明人： David Arthur Berry ,  Brett Adam Boghigian ,  Nathaniel W. Silver ,  Geoffrey von Maltzahn ,  Rajeev Chillakuru ,  Michael Hamill ,  John F. Kramarczyk

    IPC分类号： A23J3/04 ,  C07K14/435 ,  A23L1/305 ,  A61K38/17

    CPC分类号： C07K14/435 ,  A23L33/17 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/1709 ,  A23V2200/332 ,  A23V2250/54

    摘要： Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein. In some embodiments, the fragment comprises at least one of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein, that is equal to or greater than the corresponding ratio present in a benchmark protein such as whey, egg or soy protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.