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    Method and apparatus for dermatological treatment
    4.
    发明授权
    Method and apparatus for dermatological treatment 有权
    皮肤病治疗方法和装置

    公开(公告)号：US07942153B2

    公开(公告)日：2011-05-17

    申请号：US11931232

    申请日：2007-10-31

    申请人： Dieter Manstein ,  R. Rox Anderson

    发明人： Dieter Manstein ,  R. Rox Anderson

    IPC分类号： A61B19/00

    CPC分类号： A61B18/203 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/208

    摘要： The present invention provides improved methods and apparatus for skin treatment. The apparatus includes multiple sources of optical energy or several blades that are scanned along a region of skin to form micro-line patterns of damaged tissue. The micro-lines are small in at least one dimension, having a width of less than about 1 mm, and the wounded regions promote beneficial results by stimulation of wound healing and tissue remodeling.

    摘要翻译： 本发明提供了用于皮肤治疗的改进方法和装置。 该装置包括沿着皮肤区域扫描的多个光能源或几个叶片，以形成受损组织的微线图案。 微细线在至少一个维度上是小的，具有小于约1mm的宽度，受伤的区域通过刺激伤口愈合和组织重塑来促进有益的结果。

    Localized molecular and ionic transport to and from tissues
    5.
    发明授权
    Localized molecular and ionic transport to and from tissues 失效
    局部分子和离子转运到和从组织

    公开(公告)号：US06706032B2

    公开(公告)日：2004-03-16

    申请号：US09878155

    申请日：2001-06-07

    申请人： James C. Weaver ,  R. Rox Anderson ,  Terry O Herndon ,  T. R. Gowrishankar ,  Elizabeth A. Gift ,  Salvador Gonzalez

    发明人： James C. Weaver ,  R. Rox Anderson ,  Terry O Herndon ,  T. R. Gowrishankar ,  Elizabeth A. Gift ,  Salvador Gonzalez

    IPC分类号： A61M3100

    CPC分类号： A61N1/325 ,  A61M5/427 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/044 ,  A61N1/30

    摘要： The present invention relates to methods and devices used for the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. A method is described for forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue. According to an embodiment, microparticles are accelerated by being hit with a moving, solid surface. In another embodiment, microparticles are accelerated by a flowing gas or liquid. Also described are methods and devices for using microconduits to deliver therapeutic molecules and ions into tissue, or for extraction of chemical analytes out of tissue. Also described is a method of nail piercing to accommodate jewelry.

    摘要翻译： 本发明涉及用于在组织中形成微管的方法和装置。 术语“微管道”是指通过液体流动允许材料转移并通过电泳的组织中的或通过组织的小的开口，通道或孔，在多个加速的微粒撞击时形成的微管， 组织表面。 描述了一种用于在组织中形成至少一个微管的方法，包括以下步骤：将多个微粒加速到使微粒在组织表面上碰撞时穿透组织表面区域的速度; 并将微粒引向组织表面的区域，从而使微粒穿透组织并在组织中形成微管。 根据一个实施例，通过用移动的固体表面击打微粒被加速。 在另一个实施方案中，微粒被流动的气体或液体加速。 还描述了使用微管道将治疗分子和离子递送到组织中或从组织中提取化学分析物的方法和装置。 还描述了一种钉子穿孔以适应首饰的方法。

    Apparatus for controlling laser penetration depth
    6.
    发明授权
    Apparatus for controlling laser penetration depth 有权
    用于控制激光穿透深度的装置

    公开(公告)号：US06529543B1

    公开(公告)日：2003-03-04

    申请号：US09717779

    申请日：2000-11-21

    申请人： R. Rox Anderson ,  Yacov Domankevitz

    发明人： R. Rox Anderson ,  Yacov Domankevitz

    IPC分类号： H01S308

    CPC分类号： A61B18/203 ,  A61B2018/00452 ,  A61B2018/2277

    摘要： The invention features systems and tools for controlling the optical penetration depth of laser energy, e.g., when delivering laser energy to target tissue in a patient. The systems and tools control the optical penetration depth (OPD) by controlling the incident angle at which the laser energy is delivered to the target area of the patient. Embodiments of the invention include an optical coupler that permit a user to vary the incident angle and thereby selectably control the OPD of incident laser energy. Fabricating the optical coupler to have a refractive index greater than that of the target tissue can enhance the range of selectable OPDs. The laser energy, which is delivered to the desired depth, can cause alteration of the target tissue by, e.g., heating, ablation, and/or photochemical reaction.

    摘要翻译： 本发明的特征在于用于控制激光能量的光学穿透深度的系统和工具，例如当将激光能量传送到患者中的目标组织时。 系统和工具通过控制激光能量输送到患者的目标区域的入射角来控制光学穿透深度（OPD）。 本发明的实施例包括允许用户改变入射角并由此可选地控制入射激光能量的OPD的光耦合器。 制造光学耦合器以具有比目标组织的折射率更大的折射率可以增强可选OPD的范围。 输送到所需深度的激光能量可以通过例如加热，消融和/或光化学反应来引起靶组织的改变。

    Method and apparatus for disruption of the epidermis
    7.
    发明授权
    Method and apparatus for disruption of the epidermis 失效
    破坏表皮的方法和装置

    公开(公告)号：US5879326A

    公开(公告)日：1999-03-09

    申请号：US845627

    申请日：1997-04-25

    申请人： Ned Allen Godshall ,  R. Rox Anderson

    发明人： Ned Allen Godshall ,  R. Rox Anderson

    IPC分类号： A61B17/00 ,  A61B17/20 ,  A61M35/00 ,  A61M37/00 ,  A61M31/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61M35/00 ,  A61B2017/00761 ,  A61M2037/0007 ,  A61M2037/0046 ,  A61M2037/0053

    摘要： A method and apparatus for mechanically disrupting a layer of skin having a known thickness without substantially disrupting underlying dermis layers below the layer of skin in question so as to facilitate the delivery of compounds across the disrupted layer. The apparatus includes a cutter having a plurality of microprotrusions having a height chosen with respect to the layer of skin that is to be disrupted and a stop for preventing the apparatus from penetrating the skin beyond a predetermined distance. In the preferred embodiment of the present invention, the microprotrusions include blades that generate cuts in the layer of skin. The cuts are generated by moving the apparatus parallel to the surface of the skin either at the time of application, during the normal movements of the individual wearing the apparatus, or both. In the preferred embodiment of the present invention, the appropriate length of blade is determined for each individual and delivery site on that individual.

    摘要翻译： 用于机械地破坏具有已知厚度的皮肤层的方法和装置，而不会基本上破坏所讨论的皮肤层下面的潜在的真皮层，以便促进化合物穿过破碎层。 该装置包括具有多个微突起的切割器，所述多个微突起具有相对于被破坏的皮肤层选择的高度，以及用于防止装置穿透皮肤超过预定距离的止挡件。 在本发明的优选实施例中，微突起物包括在皮肤层中产生切口的刀片。 切割是通过在施加时平行于皮肤表面移动装置，在佩戴装置的个体的正常运动期间或两者之间产生的。 在本发明的优选实施例中，为该个体上的每个个体和递送部位确定适当长度的叶片。

    Catheter devices for delivering laser energy
    8.
    发明授权
    Catheter devices for delivering laser energy 失效
    用于提供激光能量的导管装置

    公开(公告)号：US5649923A

    公开(公告)日：1997-07-22

    申请号：US225259

    申请日：1994-04-08

    申请人： Kenton W. Gregory ,  R. Rox Anderson

    发明人： Kenton W. Gregory ,  R. Rox Anderson

    IPC分类号： A61B18/20 ,  A61B17/00 ,  A61B17/22 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61D7/00 ,  A61F2/00 ,  G02B6/032 ,  A61B17/36

    CPC分类号： G02B6/032 ,  A61B18/24 ,  A61B18/245 ,  A61B2017/00853 ,  A61B2017/22038 ,  A61B2017/22072 ,  A61B2018/206 ,  A61B2018/2261 ,  A61B2090/3933 ,  A61F2210/0019

    摘要： A method for conducting laser energy to a site includes steps of bringing the proximal end of a flexible tube near the site, filling at least a proximal portion of the tube with a liquid by introducing the liquid into the tube, allowing a portion of the liquid to flow out from the proximal end of the tube toward the site, and directing laser energy from a laser energy source into the distal end of the tube, whereby a portion of the laser energy emerges from the proximal end of the tube at the site. Also, such a method in which the liquid is a radiographic contrast medium. Also, such a method for removing an obstruction from a blood vessel in an animal. Also, apparatus for delivering laser energy to a site includes a flexible tube, a liquid, the tube having an opening in a first end through which the liquid can pass, means for providing a flow of the liquid into the tube, and a source of laser energy operationally associated with a second end of the tube, wherein the tube and the liquid are adapted to cooperate, when the tube contains the liquid, to conduct laser energy from the source and to emit a portion of the laser energy from the first end of the liquid-containing tube.

    摘要翻译： 用于向现场进行激光能量的方法包括以下步骤：使柔性管的近端靠近现场，通过将液体引入管中来填充液体的至少近端部分，允许液体的一部分 从管的近端向现场流出，并将来自激光能量源的激光能量引导到管的远端，由此一部分激光能量从位于管的近端处出现。 此外，这种液体是射线照相造影剂的方法。 此外，这种用于从动物的血管中除去阻塞物的方法。 而且，向场地传递激光能量的装置包括柔性管，液体，该管在第一端具有液体可以通过的开口，用于提供液体流入管的装置和 激光能量与管的第二端可操作地相关联，其中管和液体适于在管包含液体时协作以从源引入激光能量并从第一端发射一部分激光能量 的含液管。