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公开(公告)号：US20050208654A1
公开(公告)日：2005-09-22
申请号：US11005481
申请日：2004-12-07
申请人： Rachael Clark , Thomas Kupper
发明人： Rachael Clark , Thomas Kupper
IPC分类号： A61K35/12 , C12N5/071 , C12N5/0783 , C12N5/08
CPC分类号： C12N5/0636 , A61K2035/124 , C12N5/0698 , C12N2501/23 , C12N2501/26 , C12N2501/42 , C12N2502/094 , C12N2502/1114 , C12N2502/1323 , C12N2533/10
摘要： The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts.
摘要翻译： 本发明涉及用于产生T淋巴细胞的体外方法。 该方法包括在用角质形成细胞和成纤维细胞接种的基质上培养骨髓细胞。
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2.发明授权Diagnosis and prognosis of wound infection by measurement of a phospholipase A2 in wound fluid 有权伤口感染的诊断和预后通过测量伤口液中的磷脂酶A2公开(公告)号：US08685639B2
公开(公告)日：2014-04-01
申请号：US11608940
申请日：2005-06-09
IPC分类号： C12Q1/00
CPC分类号： G01N33/573 , G01N2333/918
摘要： The present invention relates to the diagnosis, prognosis and/or treatment of wound infection by testing wound fluid for the presence of a marker which is present in an amount which is indicative of infection. The marker may be high molecular weight phospholipase A2 (cPLA2) or a marker which is correlated with cPLA2.
摘要翻译： 本发明涉及通过测试伤口液体以存在指示感染量的标记物的存在来诊断，预后和/或治疗伤口感染。 标记物可以是高分子量磷脂酶A2（cPLA2）或与cPLA2相关的标记物。
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3.发明申请DIAGNOSIS AND PROGNOSIS OF WOUND INFECTION BY MEASUREMENT OF A PHOSPHOLIPASE A2 IN WOUND FLUID 有权通过在流体中测量磷脂酶A2来诊断和预防感染公开(公告)号：US20070231380A1
公开(公告)日：2007-10-04
申请号：US11608940
申请日：2006-12-11
申请人： Faraia Shah , Rachael Clark , Patrick Trotter , Paul Watt , Breda Cullen
发明人： Faraia Shah , Rachael Clark , Patrick Trotter , Paul Watt , Breda Cullen
CPC分类号： G01N33/573 , G01N2333/918
摘要： The present invention relates to the diagnosis, prognosis and/or treatment of wound infection by testing wound fluid for the presence of a marker which is present in an amount which is indicative of infection. The marker may be high molecular weight phospholipase A2 (cPLA2) or a marker which is correlated with cPLA2.
摘要翻译： 本发明涉及通过测试伤口液体以存在指示感染量的标记物的存在来诊断，预后和/或治疗伤口感染。 标记物可以是高分子量磷脂酶A 2（cPLA 2 2）或与cPLA 2 N相关的标记物。
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4.发明申请MEASUREMENT OF CYTOSKELETAL PROTEINS AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND THERAPY 有权细胞因子蛋白质的测定及其在诊断，预防和治疗中的应用公开(公告)号：US20070141131A1
公开(公告)日：2007-06-21
申请号：US11608906
申请日：2006-12-11
申请人： Faraia Shah , Rachael Clark , Partick Trotter , Paul Watt , Breda Cullen
发明人： Faraia Shah , Rachael Clark , Partick Trotter , Paul Watt , Breda Cullen
CPC分类号： G01N33/6893
摘要： The present invention relates to monitoring patients for an inflammatory condition or infection (preferably wound infection) by testing an extracellular fluid such as a wound fluid for an elevated level of: (i) vimentin; (ii) a vimentin breakdown product; or (iii) a marker indicative of the presence of vimentin. The present invention provides methods of diagnosis and prognosis, wound dressings, devices (e.g. biosensors) and kits for use in such methods.
摘要翻译： 本发明涉及通过测试诸如伤口液的细胞外液体升高的水平来监测患者的炎症状况或感染（优选伤口感染）：（i）波形蛋白; （ii）波形蛋白分解产物; 或（iii）指示波形蛋白存在的标志物。 本发明提供诊断和预后的方法，伤口敷料，用于这些方法的装置（例如生物传感器）和试剂盒。
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公开(公告)号：US20070053961A1
公开(公告)日：2007-03-08
申请号：US11516210
申请日：2006-09-06
申请人： Rachael Clark , Breda Cullen
发明人： Rachael Clark , Breda Cullen
IPC分类号： G01N33/567 , A61L15/00
CPC分类号： G01N33/74 , G01N33/54366 , G01N33/6893 , G01N2800/20 , G01N2800/26
摘要： The present invention relates to a method of diagnosis or prognosis of a mammalian wound infection, said method comprising the step of measuring the level of at least on angiogenic factor in a sample of wound fluid. The preferred angiogenic growth factors are angiogenin and vascular endothelial growth factor (VEGF). The present invention also provides devices (e.g. biosensors) for use in such methods, and methods and products for diagnosing and treating infected wounds.
摘要翻译： 本发明涉及一种诊断或预后的哺乳动物伤口感染的方法，所述方法包括测量伤口液样品中至少血管生成因子水平的步骤。 优选的血管生成生长因子是血管生成素和血管内皮生长因子（VEGF）。 本发明还提供了用于这些方法的装置（例如生物传感器），以及用于诊断和治疗感染伤口的方法和产品。
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公开(公告)号：US20100166694A1
公开(公告)日：2010-07-01
申请号：US12450377
申请日：2008-03-31
IPC分类号： A61K31/79 , C07K16/24 , A61K31/65 , A61K31/43 , A61K31/7048 , A61K38/12 , A61K31/655 , A61K33/38 , A61P17/02 , G01N33/68 , C12Q1/02 , G01N33/53 , G01N30/00
CPC分类号： G01N33/6863 , C12Q1/04 , G01N33/54366 , G01N33/569 , G01N2800/042
摘要： The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.
摘要翻译： 本发明涉及测定受试者中伤口（特别是糖尿病性溃疡）中的微生物生物负载的方法，所述方法包括测量伤口样品中细胞因子水平的步骤，其中细胞因子水平低于 参考水平表明伤口中显着的微生物生物负载（或高于参考水平的细胞因子水平表示伤口中微生物生物负载不明显）。 本发明提供了伤口感染的诊断，预后和治疗方法，以及用于这些方法的装置和试剂盒。
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公开(公告)号：US20070053962A1
公开(公告)日：2007-03-08
申请号：US11516212
申请日：2006-09-06
申请人： Rachael Clark , Breda Cullen
发明人： Rachael Clark , Breda Cullen
IPC分类号： A61L15/00 , G01N33/567
CPC分类号： G01N33/6893 , A61L15/42 , G01N33/54366 , G01N33/566 , G01N33/6863 , G01N2800/20 , G01N2800/26
摘要： The present invention relates to a method of diagnosis or prognosis of a mammalian wound infection, said method comprising the step of measuring the level of at least one cell surface receptor in a sample of wound fluid. The preferred cell surface receptors are Intercellular adhesion molecule-1 (ICAM 1) and Tumor Necrosis Factor Receptor-2 (TNF-RII). The present invention also provides devices (e.g. biosensors) for use in such methods, and methods and products for diagnosing and treating infected wounds.
摘要翻译： 本发明涉及一种诊断或预后的哺乳动物伤口感染的方法，所述方法包括测量伤口液样品中至少一种细胞表面受体水平的步骤。 优选的细胞表面受体是细胞间粘附分子-1（ICAM1）和肿瘤坏死因子受体-2（TNF-RII）。 本发明还提供了用于这些方法的装置（例如生物传感器），以及用于诊断和治疗感染伤口的方法和产品。
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公开(公告)号：US08491852B2
公开(公告)日：2013-07-23
申请号：US11914884
申请日：2006-04-24
IPC分类号： G01N33/52
CPC分类号： G01N33/528 , C12Q1/26 , G01N33/523 , G01N33/6893
摘要： An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.
摘要翻译： 当哺乳动物伤口流体的样品的抗氧化能力超过感染伤口特征的预定最小水平时，指示装置适于产生可检测信号。 还提供了用于诊断和治疗伤口的系统，包括本发明的诊断装置和包含至少一种用于选择性应用于感染伤口的抗微生物剂的伤口敷料。 还提供了通过本发明的装置和系统进行诊断和治疗的方法。
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公开(公告)号：US20090299161A1
公开(公告)日：2009-12-03
申请号：US11914884
申请日：2006-04-24
IPC分类号： A61B5/1468 , A61F13/00 , A61M35/00
CPC分类号： G01N33/528 , C12Q1/26 , G01N33/523 , G01N33/6893
摘要： An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.
摘要翻译： 当哺乳动物伤口流体的样品的抗氧化能力超过感染伤口特征的预定最小水平时，指示装置适于产生可检测信号。 还提供了用于诊断和治疗伤口的系统，包括本发明的诊断装置和包含至少一种用于选择性应用于感染伤口的抗微生物剂的伤口敷料。 还提供了通过本发明的装置和系统进行诊断和治疗的方法。
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公开(公告)号：US20060015019A1
公开(公告)日：2006-01-19
申请号：US10519431
申请日：2003-06-25
申请人： Paul Watt , Rachael Clark
发明人： Paul Watt , Rachael Clark
IPC分类号： A61B5/00
CPC分类号： A61M1/0088 , A61M1/0025 , A61M27/00
摘要： An apparatus comprising: a distributed inlet (4) for collecting and mixing wound fluids from a plurality of locations in a wound to provide a wound fluid mixture; and a sensing or indicating device (8) in fluid communication with said distributed inlet for detecting the presence of a wound fluid marker in the wound fluid mixture.
摘要翻译： 一种装置，包括：分配入口（4），用于从伤口中的多个位置收集和混合伤口流体，以提供伤口流体混合物; 以及与所述分配的入口流体连通的感测或指示装置（8），用于检测伤口液体混合物中伤口液体标记的存在。
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