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31 条记录 (耗时 0.034 秒)

    Sensor with layered electrodes
    6.
    发明申请
    Sensor with layered electrodes 有权
    带层状电极的传感器

    公开(公告)号：US20070173711A1

    公开(公告)日：2007-07-26

    申请号：US11234523

    申请日：2005-09-23

    申请人： Rajiv Shah ,  Rebecca Gottlieb

    发明人： Rajiv Shah ,  Rebecca Gottlieb

    IPC分类号： A61B5/05

    CPC分类号： A61B5/14865 ,  A61B5/0004 ,  A61B5/0017 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849 ,  C12Q1/006 ,  C23C14/20 ,  C23C14/3414 ,  G01N27/307 ,  G01N27/3273 ,  G01N27/4166 ,  Y10T29/49002 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49155

    摘要： A thin film sensor, such as a glucose sensor, is provided for transcutaneous placement at a selected site within the body of a patient. The sensor includes several sensor layers that include conductive layers and includes a proximal segment defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment with sensor electrodes for transcutaneous placement. The sensor electrode layers are disposed generally above each other, for example with the reference electrode above the working electrode and the working electrode above the counter electrode. The electrode layers are separated by dielectric layer.

    摘要翻译： 提供薄膜传感器，例如葡萄糖传感器，用于经皮放置在患者体内的选定部位。 传感器包括几个传感器层，其包括导电层，并且包括限定适于与合适的监视器电连接的导电触点的近端段，以及具有用于经皮放置的传感器电极的远端段。 传感器电极层大致彼此上下设置，例如，在工作电极上方的参考电极和对置电极上方的工作电极。 电极层由电介质层分离。

    Method and apparatus for enhancing the integrity of an implantable sensor device
    7.
    发明授权
    Method and apparatus for enhancing the integrity of an implantable sensor device 有权
    用于增强可植入传感器装置完整性的方法和装置

    公开(公告)号：US07162289B2

    公开(公告)日：2007-01-09

    申请号：US10335574

    申请日：2002-12-31

    申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

    发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

    IPC分类号： A61B5/00 ,  A61B5/05 ,  C12M1/00 ,  C12Q1/00

    CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

    摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

    摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

    System and method for restenosis mitigation
    8.
    发明申请
    System and method for restenosis mitigation 审中-公开
    减轻再狭窄的系统和方法

    公开(公告)号：US20050033263A1

    公开(公告)日：2005-02-10

    申请号：US10638215

    申请日：2003-08-07

    申请人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

    发明人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

    IPC分类号： A61F2/90 ,  A61M31/00

    CPC分类号： A61F2/90 ,  A61F2230/0054 ,  A61M2025/105

    摘要： A system and method for restenosis mitigation at a trauma site within the vasculature. The system may include a catheter capable of delivering a restenosis mitigating drug and a sensor extending through a lumen in the catheter. The catheter may be positioned adjacent the trauma site and the restenosis mitigating drug may be delivered to the trauma site through the catheter. The restenosis mitigating drug or some other parameter may be sensed by the sensor.

    摘要翻译： 在脉管系统内的创伤部位减轻再狭窄的系统和方法。 该系统可以包括能够递送再狭窄缓解药物的导管和延伸穿过导管内腔的传感器。 导管可以定位在创伤部位附近，并且再狭窄缓解药物可以通过导管输送到创伤部位。 再狭窄缓解药物或某些其他参数可由传感器检测。

    MULTILUMEN CATHETER
    9.
    发明申请
    MULTILUMEN CATHETER 有权
    多层导管

    公开(公告)号：US20080221509A1

    公开(公告)日：2008-09-11

    申请号：US12121647

    申请日：2008-05-15

    申请人： Rebecca Gottlieb ,  Rajiv Shah ,  Mary M. Morris ,  Victor Giron ,  Michael E. Miller ,  Bradley J. Enegren

    发明人： Rebecca Gottlieb ,  Rajiv Shah ,  Mary M. Morris ,  Victor Giron ,  Michael E. Miller ,  Bradley J. Enegren

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0032 ,  A61B5/028 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/415 ,  A61M5/14244 ,  A61M5/1723 ,  A61M25/0017 ,  A61M25/0023 ,  A61M2025/0003 ,  A61M2025/0046 ,  A61M2230/201 ,  Y10T29/49826

    摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.

    摘要翻译： 一种多管导管，其具有延伸到导管内腔内的管道。 流明可用于血液，药物或其他药物。 流明也可用于传感器。 患者外部的连接元件将管道连接到管腔。 也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。 具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。 传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。 另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。 第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。 在其他版本中，中心线导管可以具有另外的流明用于其他目的。 此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。