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    Titanuim Dioxide Pigments, Process For The Production Thereof,And Resin Compostions Containing The Pigments
    1.
    发明申请
    Titanuim Dioxide Pigments, Process For The Production Thereof,And Resin Compostions Containing The Pigments 有权
    钛酸二甲酯颜料，其制备方法和含有颜料的树脂组合物

    公开(公告)号：US20070295244A1

    公开(公告)日：2007-12-27

    申请号：US11629990

    申请日：2005-06-23

    申请人： Ralf Himmelreich ,  Sabine Werner ,  Claudia Fritz ,  Hideo Takahashi ,  Masaki Shimojoh ,  Toshihiko Akamatsu ,  Keisuke Iriyama

    发明人： Ralf Himmelreich ,  Sabine Werner ,  Claudia Fritz ,  Hideo Takahashi ,  Masaki Shimojoh ,  Toshihiko Akamatsu ,  Keisuke Iriyama

    IPC分类号： C08K9/00 ,  C09C1/36 ,  C09C3/06

    CPC分类号： C09C1/3692 ,  C01P2006/12 ,  C08K9/06 ,  C09C1/3661 ,  C09C1/3669 ,  C09C1/3684 ,  Y10T428/2993 ,  Y10T428/2995

    摘要： The invention provides titanium dioxide pigments for plastics resin compositions which are excellent in dispersibility, light resistance, and weather resistance and little cause surface imperfection. In particular, the invention provides a titanium dioxide pigment suitable for general-purpose plastics resin compositions which can attain excellent dispersion and lacing resistance even when blended in a high concentration; a titanium dioxide pigment suitable for engineering plastics resin compositions which can attain dispersion properties, silver streaking resistance, inhibition of reduction in molecular weight, and thermal discoloration resistance at high levels; a process for the production of the pigments; and resin compositions containing the pigments. A titanium dioxide pigment for plastics resin compositions, characterized in that each titanium dioxide particle has a dense hydrous silica coat covering its surface and an organic compound coat formed on the silica coat not through an interlayer.

    摘要翻译： 本发明提供了分散性，耐光性和耐候性优异且表面不完美的塑料树脂组合物用二氧化钛颜料。 特别地，本发明提供了适用于通用塑料树脂组合物的二氧化钛颜料，即使以高浓度混合也能获得优异的分散性和耐蕾曲性; 适用于工程塑料树脂组合物的二氧化钛颜料，其可以获得分散性能，银耐划伤性，抑制分子量降低和高水平的耐热变色性; 一种生产颜料的方法; 和含有颜料的树脂组合物。 一种用于塑料树脂组合物的二氧化钛颜料，其特征在于，每个二氧化钛颗粒具有覆盖其表面的致密含水二氧化硅涂层和在二氧化硅涂层上形成的有机复合涂层，而不是通过中间层。

    Rapid and Low Cost Method for Isolating Nucleic Acid
    2.
    发明申请
    Rapid and Low Cost Method for Isolating Nucleic Acid 审中-公开
    快速低成本的分离核酸的方法

    公开(公告)号：US20080166703A1

    公开(公告)日：2008-07-10

    申请号：US10577721

    申请日：2004-10-20

    申请人： Ralf Himmelreich ,  Sabine Werner ,  Claudia Fritz

    发明人： Ralf Himmelreich ,  Sabine Werner ,  Claudia Fritz

    IPC分类号： C12Q1/68 ,  C07H1/00

    CPC分类号： C12N15/1017 ,  C07H1/08

    摘要： The invention relates to a rapid method for isolating nucleic acid from a nucleic acid source, wherein the nucleic acid source is lysed in the absence of a chaotropic salt and in the absence of an alcohol. The lysate is subsequently filtered through a porous matrix consisting of a material based on silica or of a silica coated material, which binds the nucleic acid in the absence of a chaotropic salt and in the absence of an alcohol. Finally, the nucleic acid is eluted from the porous matrix by an aqueous buffer solution. Furthermore, this invention relates to a test kit in order to isolate the nucleic acid.

    摘要翻译： 本发明涉及从核酸源分离核酸的快速方法，其中核酸源在不存在离液序列盐的情况下裂解，并且在不存在醇的情况下裂解。 裂解物随后通过由基于二氧化硅或二氧化硅涂覆的材料的材料组成的多孔基质过滤，所述材料在不存在离液序列盐的情况下结合核酸，并且在不存在醇的情况下。 最后，通过缓冲液水溶液从多孔基质中洗脱核酸。 此外，本发明涉及用于分离核酸的测试试剂盒。

    Method For Facilitating an Automated Isolation of a Biopolymer Using Magnetic Particles
    4.
    发明申请
    Method For Facilitating an Automated Isolation of a Biopolymer Using Magnetic Particles 有权
    促进使用磁性颗粒自动分离生物聚合物的方法

    公开(公告)号：US20080132694A1

    公开(公告)日：2008-06-05

    申请号：US10567351

    申请日：2004-08-16

    申请人： Ralf Himmelreich ,  Sabine Werner

    发明人： Ralf Himmelreich ,  Sabine Werner

    IPC分类号： C07H21/04

    CPC分类号： C12N15/1013

    摘要： The present invention provides a method for isolating biopolymers, particularly nucleic acids, such as DNA or RNA or hybrid molecules of DNA and RNA, from an aqueous solution utilizing magnetic particles, particularly silica magnetic particles. The method of the present invention involves forming a complex of the magnetic particles and the biopolymer in a mixture of said particles and said aqueous solution, comprising a salt and an additive; separating the complex from the mixture by a magnetic force, and eluting the biopolymer from the complex, wherein advantageously no substantial clustering of said magnetic particles occurs during the performance of the method. In a preferred embodiment the method of the invention is performed as an automated process.

    摘要翻译： 本发明提供一种利用磁性颗粒，特别是二氧化硅磁性颗粒从水溶液中分离生物聚合物，特别是核酸，如DNA或RNA或DNA和RNA的混合分子的方法。 本发明的方法包括在所述颗粒和所述水溶液的混合物中形成磁性颗粒和生物聚合物的复合物，其包含盐和添加剂; 通过磁力将复合物与混合物分离，并从复合物中洗脱生物聚合物，其中在实施该方法期间有利地不发生所述磁性颗粒的基本聚集。 在优选实施例中，本发明的方法作为自动化过程进行。

    Method for isolating and purifying nucleic acids
    7.
    发明授权
    Method for isolating and purifying nucleic acids 失效
    分离和纯化核酸的方法

    公开(公告)号：US08624020B2

    公开(公告)日：2014-01-07

    申请号：US13061928

    申请日：2009-09-02

    申请人： Ralf Himmelreich ,  Sabine Werner

    发明人： Ralf Himmelreich ,  Sabine Werner

    IPC分类号： C07H21/00

    CPC分类号： C12N15/1006

    摘要： The present invention relates to a method for the isolation and purification of nucleic acids by elution of nucleic acids from nucleic acid-containing samples, and biological materials, using a wash buffer comprising an alcohol having 1 to 3 carbon atoms and at least one further solvent selected from the group consisting of alkane diols and alkane triols having 2 to 6 carbon atoms, monocarboxylic acid esters and dicarboxylic acid diesters having 2 to 6 carbon atoms in the acidic component and 1 to 4 carbon atoms in the alcoholic component; (poly)ethylene glycols and ether derivatives and ester derivatives thereof, and poly(4-styrene sulfonic acid-co-maleic acid) sodium salt solution. The present invention further relates to a kit for carrying out the method of the invention.

    摘要翻译： 本发明涉及通过使用含有1至3个碳原子的醇和至少一种其它溶剂的洗涤缓冲液从核酸样品和生物材料中洗脱核酸来分离和纯化核酸的方法 选自烷烃二醇和具有2至6个碳原子的烷烃三醇，在酸性组分中具有2至6个碳原子的二羧酸二酯和醇组分中的1至4个碳原子的单羧酸酯和二羧酸二酯; （聚）乙二醇及其醚衍生物及其酯衍生物，以及聚（4-苯乙烯磺酸 - 共 - 马来酸）钠盐溶液。 本发明还涉及用于实施本发明方法的试剂盒。

    Method for facilitating an automated isolation of a biopolymer using magnetic particles
    8.
    发明授权
    Method for facilitating an automated isolation of a biopolymer using magnetic particles 有权
    促进使用磁性颗粒自动分离生物聚合物的方法

    公开(公告)号：US08729252B2

    公开(公告)日：2014-05-20

    申请号：US10567351

    申请日：2004-08-16

    申请人： Ralf Himmelreich ,  Sabine Werner

    发明人： Ralf Himmelreich ,  Sabine Werner

    IPC分类号： C07H21/00

    CPC分类号： C12N15/1013

    摘要： A method for isolating polynucleotides, such as DNA, RNA and hybrids thereof from an aqueous solution containing polynucleotides by reversibly binding the polynucleotides to silica-coated magnetic particles in the presence of a salt and non-ionic hydratable additive is disclosed. The salt and non-ionic hydratable additive concentrations are adjusted to levels that result in adhesion of the nucleic acid to the particles without degradation or precipitation of the nucleic acid.

    摘要翻译： 公开了一种从含有多核苷酸的水溶液中分离多核苷酸（如DNA，RNA及其杂合物）的方法，通过在盐和非离子可氢化添加剂的存在下将多核苷酸可逆地结合二氧化硅包被的磁性颗粒。 将盐和非离子可氢化添加剂浓度调节至导致核酸与颗粒粘附而不降解或沉淀核酸的水平。

    Test cassette for measuring capstan azimuth angles
    10.
    发明授权
    Test cassette for measuring capstan azimuth angles 失效
    用于测量主导方位角的测试盒

    公开(公告)号：US4743990A

    公开(公告)日：1988-05-10

    申请号：US944300

    申请日：1986-12-18

    申请人： Sabine Werner

    发明人： Sabine Werner

    IPC分类号： G01B7/31 ,  G11B15/28 ,  G11B15/60 ,  G11B23/00 ,  G11B23/04 ,  G11B5/02

    CPC分类号： G01B7/31 ,  G11B15/28 ,  G11B15/60 ,  G11B23/049

    摘要： Azimuth angle of the capstan of a magnetic-tape-cassette apparatus is measured using a cassette having a reference sensor which engages the cassette, and at least one measurement sensor which engages the cassette at a location spaced axially from the reference sensor. The measurement sensor includes an electrical measuring element such as a strain gauge which provides an indication of the position of the element with respect to the reference sensor. The azimuth angle can readily be computed using the known axial spacing between the sensors and the electrical value transmitted from the measurement sensor.

    摘要翻译： 使用具有与该盒接合的基准传感器的盒以及至少一个测量传感器来测量磁带盒装置的绞盘的方位角，以及至少一个测量传感器，该测量传感器在与参考传感器轴向间隔开的位置处接合盒。 测量传感器包括电测量元件，例如应变仪，其提供元件相对于参考传感器的位置的指示。 可以使用传感器之间的已知轴向距离和从测量传感器传输的电气值容易地计算方位角。