公开(公告)号：US07759350B2

公开(公告)日：2010-07-20

申请号：US11516549

申请日：2006-09-07

申请人： Ravikumar Tadipartiii ,  Venkatesan Parameswaran ,  Rajib Barik ,  Gaddam Om Reddy ,  Pawan Aggarwal ,  Sappanimuthu Thirunavukkarasu ,  Sriram Rajagopal

发明人： Ravikumar Tadipartiii ,  Venkatesan Parameswaran ,  Rajib Barik ,  Gaddam Om Reddy ,  Pawan Aggarwal ,  Sappanimuthu Thirunavukkarasu ,  Sriram Rajagopal

IPC分类号： C07D239/28 ,  A61K31/505

CPC分类号： C07D239/38 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04

摘要： The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly relates to novel pyrimidine carboxamides of the general formula (I). Also included is a method of prophylaxis or treatment of a pain disorder, immunological diseases, inflammation, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

摘要翻译： 本发明涉及通式（I）的新化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，它们的水合物，它们的溶剂化物，其药学上可接受的盐和组合物，其代谢物和前药。 本发明更具体地涉及通式（I）的新型嘧啶甲酰胺。 还包括预防或治疗疼痛障碍，免疫疾病，炎症，类风湿性关节炎的方法; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 恶病质 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 败血症 败血性休克 中毒性休克综合征; 发热和由于哺乳动物感染引起的肌痛，包括给予有效量的如上所述的式（I）化合物。

公开(公告)号：US20080207606A1

公开(公告)日：2008-08-28

申请号：US12068668

申请日：2008-02-08

申请人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

发明人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

IPC分类号： A61K31/541 ,  C07D239/24 ,  A61K31/505 ,  A61K31/496 ,  A61P37/00 ,  A61P35/00 ,  A61P19/02 ,  A61P29/00 ,  C07D295/00 ,  A61K31/5377

CPC分类号： C07D213/30 ,  C07D239/30 ,  C07D239/32 ,  C07D239/34 ,  C07D239/42 ,  C07D239/52 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell-damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors, and useful for treating PDE4 mediated diseases.

摘要翻译： 描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 动脉粥样硬化 癌症; 恶病质 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症 败血症 败血性休克 中毒性休克综合征和发烧。 更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

公开(公告)号：US07863446B2

公开(公告)日：2011-01-04

申请号：US12068668

申请日：2008-02-08

申请人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

发明人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran

IPC分类号： C07D239/24 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/505 ,  A61K31/506 ,  A61P11/06 ,  A61P17/04 ,  A61P19/02 ,  A61P1/00 ,  A61P25/00

CPC分类号： C07D213/30 ,  C07D239/30 ,  C07D239/32 ,  C07D239/34 ,  C07D239/42 ,  C07D239/52 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell-damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors, and useful for treating PDE4 mediated diseases.

摘要翻译： 描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可用于治疗免疫性疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 动脉粥样硬化 癌症; 恶病质 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征和发烧。 更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

公开(公告)号：US20070167413A1

公开(公告)日：2007-07-19

申请号：US11633053

申请日：2006-12-04

申请人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam

发明人： Akella Satya Surya Visweswara Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Sappanimuthu Thirunavukkarasu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narsimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam

IPC分类号： A61K31/655 ,  A61K31/506 ,  C07D403/04

CPC分类号： C07D239/42 ,  C07D213/30 ,  C07D239/32 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel hetereocycles of the general formula (I). Also included is a method of treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

摘要翻译： 本发明涉及通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和组合物，其代谢物和前药。 本发明更具体地提供了通式（I）的新颖的杂环。 还包括治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎的方法; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 缺血性心脏病; 动脉粥样硬化 癌症; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; 成人呼吸窘迫综合征（ARDS）; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 恶病质 哮喘; 骨吸收疾病; 缺血再灌注损伤; 脑外伤; 多发性硬化症 脓毒症 败血性休克 中毒性休克综合征; 发热和由于哺乳动物感染引起的肌痛，包括给予有效量的如上所述的式（I）化合物。

公开(公告)号：US08263044B2

公开(公告)日：2012-09-11

申请号：US12084430

申请日：2006-11-06

申请人： Akella Satya Surya Visweswara Srinivas ,  Urkalan Kaveri Balan ,  Narayana Swamy Punthalir ,  Rama Swamy Velmurugan ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Virendra Kachhadia

发明人： Akella Satya Surya Visweswara Srinivas ,  Urkalan Kaveri Balan ,  Narayana Swamy Punthalir ,  Rama Swamy Velmurugan ,  Sriram Rajagopal ,  Gaddam Om Reddy ,  Virendra Kachhadia

IPC分类号： A61K9/12 ,  A61K31/427 ,  A61K31/4409 ,  C07D417/04 ,  C07D213/56 ,  A61P35/00

CPC分类号： C07C259/06 ,  C07C237/22 ,  C07C323/62 ,  C07D213/56 ,  C07D277/30 ,  C07D277/46 ,  C07D277/58 ,  C07D277/82 ,  C07D307/56 ,  C07D333/24 ,  C07D333/28 ,  C07D417/06

摘要： The present invention relates to novel stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel stilbene like compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I) as described above.

摘要翻译： 本发明涉及通式（I）的新颖的二苯乙烯类化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药。 本发明更具体地提供了通式（I）的新颖的二苯乙烯类化合物。 还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括给予有效量的如上所述的新的式（I）化合物。

公开(公告)号：US07786142B2

公开(公告)日：2010-08-31

申请号：US11546299

申请日：2006-10-12

申请人： Siripragada Mahender Rao ,  Akella Satya Surya Visweswara Srinvas ,  Shikha Rani ,  Gaddam Om Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Savaraiah Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

发明人： Siripragada Mahender Rao ,  Akella Satya Surya Visweswara Srinvas ,  Shikha Rani ,  Gaddam Om Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Savaraiah Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

IPC分类号： A61K31/4468 ,  A61K31/403 ,  C07D405/14 ,  C07D209/88

CPC分类号： C07D209/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12

摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above

摘要翻译： 本发明涉及通式（I）的新型杂环化合物，作为IL-6抑制剂，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其水合物，其溶剂合物，其药学上可接受的盐和组合物 ，它们的代谢物和前药。 本发明更具体地提供了通式（I）的新型杂环化合物。 还包括在哺乳动物中治疗癌症，癌症恶病质和炎性疾病的方法，包括免疫疾病，特别是通过pSTAT3抑制的细胞因子如IL-6介导的疾病，包括给予有效量的式（I）化合物， 如上所述

公开(公告)号：US07335656B2

公开(公告)日：2008-02-26

申请号：US11512863

申请日：2006-08-30

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： A61M31/00 ,  A61F2/86 ,  C07D251/70 ,  C07D251/52 ,  C07D251/30 ,  A61P35/00

CPC分类号： A61K31/53 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.

摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法，化合物和组合物，并且涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明还涉及抑制平滑肌增殖的化合物，例如通过调节HSPG如Perlecan。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。 本发明还涉及包括设置在医疗装置上或内部的本发明的化合物或组合物的医疗装置，例如支架。

公开(公告)号：US07112587B2

公开(公告)日：2006-09-26

申请号：US10400134

申请日：2003-03-26

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi ,  Potlapally Rajendar Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi ,  Potlapally Rajendar Kumar ,  Gaddam Om Reddy

IPC分类号： C07D251/30 ,  C07D251/46 ,  C07D251/48 ,  A61K31/53 ,  A61P35/00

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：US07335770B2

公开(公告)日：2008-02-26

申请号：US10808210

申请日：2004-03-24

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Velagala Venkata Rama Murali Krishna Reddy ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Koteswar Rao Yeleswarapu ,  Gaddam Om Reddy ,  Potlapally Rajender Kumar

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Velagala Venkata Rama Murali Krishna Reddy ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Koteswar Rao Yeleswarapu ,  Gaddam Om Reddy ,  Potlapally Rajender Kumar

IPC分类号： C07D251/54 ,  C07D251/48 ,  C07D251/18 ,  C07D251/42 ,  A61K31/53 ,  A61P35/00

CPC分类号： C07D251/46

摘要： The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.

摘要翻译： 本发明涉及三嗪化合物及其类似物和衍生物，以及包含这些化合物的方法和组合物。 本发明的化合物和组合物尤其可用于治疗由炎症反应引起的病理生理学病症，抑制或阻断糖基化蛋白产生内皮细胞中信号传导相关炎症反应的诱导，抑制平滑肌增生，治疗血管闭塞症状 其特征在于平滑肌增生如再狭窄和动脉粥样硬化等。

公开(公告)号：US07169785B2

公开(公告)日：2007-01-30

申请号：US10400169

申请日：2003-03-26

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishma Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishma Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： C07D251/42 ,  C07D251/48 ,  C07D251/54 ,  C07D239/24 ,  C07D213/02 ,  A61K31/53 ,  A61K31/506 ,  A61K35/00 ,  A61K31/424 ,  A61K31/427 ,  A61K31/4427

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/54 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.