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    Process for making carbapenem compounds
    1.
    发明授权
    Process for making carbapenem compounds 有权
    制备碳青霉烯类化合物的方法

    公开(公告)号：US07022841B2

    公开(公告)日：2006-04-04

    申请号：US10485134

    申请日：2002-09-20

    申请人： Raymond Cvetovich ,  Robert Wenslow ,  John M. Williams ,  Daniel Sidler ,  Louis Crocker ,  Hsien-Hsin Tung ,  Brian K. Johnson ,  Joseph Kukura, II ,  Ulf Dolling

    发明人： Raymond Cvetovich ,  Robert Wenslow ,  John M. Williams ,  Daniel Sidler ,  Louis Crocker ,  Hsien-Hsin Tung ,  Brian K. Johnson ,  Joseph Kukura, II ,  Ulf Dolling

    IPC分类号： C07D477/20

    CPC分类号： C07D477/20 ,  C07D477/02

    摘要： The present invention relates to a process for reducing the levels of organic solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula I: or a salt thereof, wherein R1 and R2, are the same or different, and are selected from H, alkyl, aryl, and heteroaryl, comprising washing a carbapenem solid containing organic solvent with an organic solvent containing water; and using vacuum and/or inert gas (hydrated or dry) at low temperature to produce a compound of formula I containing pharmaceutically acceptable levels of organic solvents, wherein the water content of the crystalline carbapenem solid, correcting for organic solvents, is maintained at about 13% to about 25% during the process.

    摘要翻译： 本发明涉及一种将由式I表示的热不稳定结晶碳青霉烯固体中的有机溶剂水平降低到可药用水平的方法：或其盐，其中R 1和R 2 包括相同或不同的选自H，烷基，芳基和杂芳基，包括用含水的有机溶剂洗涤含有有机溶剂的碳青霉烯固体; 并在低温下使用真空和/或惰性气体（水合或干燥）以产生含有药学上可接受水平的有机溶剂的式I化合物，其中将有机溶剂校正的结晶碳青霉烯固体的水含量保持在约 13％至25％。

    Wind resistant tile roofing system
    4.
    发明授权
    Wind resistant tile roofing system 有权
    防风瓦屋面系统

    公开(公告)号：US08661760B2

    公开(公告)日：2014-03-04

    申请号：US13742187

    申请日：2013-01-15

    申请人： John M. Williams ,  Albert L. Galloup

    发明人： John M. Williams ,  Albert L. Galloup

    IPC分类号： E04D1/34

    CPC分类号： E04D1/34 ,  E04D2001/3411 ,  E04D2001/3458 ,  E04D2001/3494

    摘要： An integral strip and fastener installation system is provided for light weight slate and tile roofing systems installed with a single overlap between each row or course of tile. A specialized fastener hook is formed with one or more lateral projections or wings installed underneath one or more slate tiles to anchor the fastener to the roof at least in part by the weight of the overlying tiles. This anchoring supports and reinforces the open mouth of the hook against deflection from high winds and thereby enables the hook to hold a tile securely under high wind loads.

    摘要翻译： 提供一体的条带和紧固件安装系统，用于在每行或每个瓦片之间安装有单个重叠的轻质板岩和瓦面屋顶系统。 一种专门的紧固钩形成有一个或多个横向突起或翼，其安装在一个或多个板岩砖下面，至少部分地通过重叠的瓦片的重量将紧固件锚定到屋顶。 这种锚定支撑并加强了钩子的敞开的口部，防止了从大风中的偏转，从而使得钩子能够在高风荷载下牢固地固定瓦片。

    Wind Resistant Tile Roofing System
    6.
    发明申请
    Wind Resistant Tile Roofing System 有权
    防风瓦屋面系统

    公开(公告)号：US20130180201A1

    公开(公告)日：2013-07-18

    申请号：US13742187

    申请日：2013-01-15

    申请人： John M. Williams ,  Albert L. Galloup

    发明人： John M. Williams ,  Albert L. Galloup

    IPC分类号： E04D1/34

    CPC分类号： E04D1/34 ,  E04D2001/3411 ,  E04D2001/3458 ,  E04D2001/3494

    摘要： An integral strip and fastener installation system is provided for light weight slate and tile roofing systems installed with a single overlap between each row or course of tile. A specialized fastener hook is formed with one or more lateral projections or wings installed underneath one or more slate tiles to anchor the fastener to the roof at least in part by the weight of the overlying tiles. This anchoring supports and reinforces the open mouth of the hook against deflection from high winds and thereby enables the hook to hold a tile securely under high wind loads.

    摘要翻译： 提供一体的条带和紧固件安装系统，用于在每行或每个瓦片之间安装有单个重叠的轻质板岩和瓦面屋顶系统。 一种专门的紧固钩形成有一个或多个横向突起或翼，其安装在一个或多个板岩砖下面，至少部分地通过重叠的瓦片的重量将紧固件锚定到屋顶。 这种锚定支撑并加强了钩子的敞开的口部，防止了从大风中的偏转，从而使得钩子能够在高风荷载下牢固地固定瓦片。

    Double sided polypropylene knit loop fabric
    7.
    发明授权
    Double sided polypropylene knit loop fabric 有权
    双面聚丙烯编织圈布

    公开(公告)号：US07926307B1

    公开(公告)日：2011-04-19

    申请号：US11416343

    申请日：2006-05-02

    申请人： John M. Williams

    发明人： John M. Williams

    IPC分类号： D04B7/12

    CPC分类号： D04B1/02

    摘要： A double sided polypropylene knit loop fabric comprises at least one and preferably both of the inner and outer loops comprised of polypropylene yarn forming cantilevered loops from a knit fabric. Polypropylene has many different characteristics than those of cotton or cotton blends. Accordingly, by making at least one of the loops, if not both of the loops, and the tie yarn out at least substantially, if not principally, polypropylene, a fabric can be produced which has different characteristics than a cotton fabric of similar construction.

    摘要翻译： 双面聚丙烯编织圈织物包括由针织织物形成悬臂环的聚丙烯纱线组成的至少一个，优选两个内圈和外圈。 聚丙烯具有许多不同于棉或棉混纺的特性。 因此，通过使至少一个环（如果不是两个环）和连接纱至少基本上（即使不是主要地）聚丙烯，也可以生产出具有与类似结构的棉织物不同的特性的织物。

    Decarboxylation process for synthesizing carbapenem antibiotics
    8.
    发明授权
    Decarboxylation process for synthesizing carbapenem antibiotics 有权
    合成碳青霉烯类抗生素的方法

    公开(公告)号：US06504027B1

    公开(公告)日：2003-01-07

    申请号：US09487044

    申请日：2000-01-19

    申请人： John M. Williams ,  Karel M. J. Brands ,  Renato T. Skerlj ,  Peter Houghton

    发明人： John M. Williams ,  Karel M. J. Brands ,  Renato T. Skerlj ,  Peter Houghton

    IPC分类号： C07D47720

    CPC分类号： C07D477/20 ,  C07D477/02

    摘要： A process for the direct crystallization of a compound of the formula I: or a pharmaceutically acceptable salt thereof, is disclosed, wherein R1 and R2 represent H, C1-10 alkyl, aryl or heteroaryl, or substituted C1-10 alkyl, aryl or heteroaryl and X+ represents a charge balancing group, comprising extracting a solution containing a crude compound of formula I or Ia: or a pharmaceutically acceptable salt thereof, wherein each X+ is a charge balancing group, and R1 and R2 are as described above with a C4-10 alcohol, collecting and crystallizing the resulting aqueous phase to produce a crystalline compound of formula I.

    摘要翻译： 公开了用于直接结晶式I化合物或其药学上可接受的盐的方法，其中R 1和R 2表示H，C 1-10烷基，芳基或杂芳基或取代的C 1-10烷基，芳基或杂芳基 并且X +表示电荷平衡基团，其包括提取含有式I或Ia的粗化合物或其药学上可接受的盐的溶液，其中每个X +是电荷平衡基团，并且R 1和R 2如上所述与C 4- 10酒精，收集和结晶所得水相以产生式I的结晶化合物。

    Implantable electrophysiology lead and method of making
    10.
    发明授权
    Implantable electrophysiology lead and method of making 失效
    植入式电生理学导论和制作方法

    公开(公告)号：US5358516A

    公开(公告)日：1994-10-25

    申请号：US988998

    申请日：1992-12-11

    申请人： David J. Myers ,  John M. Williams

    发明人： David J. Myers ,  John M. Williams

    IPC分类号： A61N1/05 ,  H01B3/44 ,  H01B7/282 ,  A61N5/04

    CPC分类号： A61N1/05 ,  H01B3/445 ,  H01B7/2825

    摘要： An implantable lead in the form of an electrical conductor wire having an insulating layer of impervious plastic surrounding the surface of the electrical conductor wire and further having an exterior surface covering of porous PTFE. The impervious plastic insulating layer is preferably a thermoplastic and most preferably a thermoplastic fluoropolymer such as ETFE, FEP or PFA. The exterior surface covering of porous PTFE offers improved flexibility and biocompatibility in comparison to conventional lead wires having silicone exterior surfaces, while the impervious plastic insulating layer prevents loss of insulating integrity resulting from wetting out of the porous PTFE exterior surface by body fluids. Methods of making the implantable lead are also described.

    摘要翻译： 电导体线形式的可植入引线，其具有围绕电导体线表面的不透水塑料的绝缘层，并且还具有覆盖多孔PTFE的外表面。 不透水的塑料绝缘层优选为热塑性，最优选热塑性含氟聚合物，例如ETFE，FEP或PFA。 与具有硅氧烷外表面的常规引线相比，多孔PTFE的外表面覆盖物提供了改进的柔性和生物相容性，而不透水塑料绝缘层防止了由体液润湿多孔PTFE外表面导致的绝缘完整性损失。 还描述了制造可植入引线的方法。