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    Collagen-binding proteins from enterococcal bacteria
    3.
    发明授权
    Collagen-binding proteins from enterococcal bacteria 有权
    来自肠球菌的胶原蛋白结合蛋白

    公开(公告)号：US06908994B1

    公开(公告)日：2005-06-21

    申请号：US09568470

    申请日：2000-05-10

    申请人： Rebecca L. Rich ,  Bernd Kriekemeyer ,  Rick T. Owens ,  Magnus Hook ,  Barbara E. Murray ,  Sreedhar R. Nallapareddy ,  George M. Weinstock

    发明人： Rebecca L. Rich ,  Bernd Kriekemeyer ,  Rick T. Owens ,  Magnus Hook ,  Barbara E. Murray ,  Sreedhar R. Nallapareddy ,  George M. Weinstock

    IPC分类号： A61K39/02 ,  C07K16/12 ,  G01N33/569 ,  C07H21/04 ,  A61K39/00 ,  C07H21/02

    CPC分类号： G01N33/56938 ,  A61K39/02 ,  A61K2039/505 ,  C07K16/1271 ,  C07K16/1275 ,  G01N2333/315

    摘要： A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized in a similar manner as other collagen-binding MSCRAMMs to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, which appears to be equivalent to the minimal ligand-binding region of the collagen-binding protein Cna (Cna 151-318), and contains several 47-residue tandem repeat units, called B domain repeat units, between the collagen-binding site and cell wall-associated regions. The Ace protein of the invention can thus be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate. The Ace protein of the present invention is thus a functional collagen-binding MSCRAMM and can be utilized to treat or prevent invention in the same manner as other isolated MSCRAMMs have been utilized, namely in methods of treating or preventing infections and diseases caused by enterococcal bacteria.

    摘要翻译： 提供了一种与来自肠球菌的Ace的胶原结合的MSCRAMM，其与来自金黄色葡萄球菌的胶原结合MSCRAMM的Cna的配体结合区同源，并且可以以与其它胶原结合的MSCRAMM类似的方式用于抑制 肠球菌对细胞外基质蛋白的粘附。 Ace的N末端区域包含一个似乎等同于胶原结合蛋白Cna（Cna 151-318）的最小配体结合区域的区域（残基174-319）或A结构域，并且包含几个 在胶原结合位点和细胞壁相关区域之间的称为B结构域重复单元的47个残基串联重复单元。 因此，本发明的Ace蛋白质可用于预防和/或治疗肠球菌感染的方法，此外，针对Ace或其A结构域产生的抗体可用于有效抑制肠球菌细胞与胶原底物的粘附 。 因此，本发明的Ace蛋白是功能性胶原结合MSCRAMM，并且可以以与其它已分离的MSCRAMM相同的方式用于治疗或预防发明，即治疗或预防由肠球菌引起的感染和疾病的方法 。

    Multicomponent vaccines
    6.
    发明授权
    Multicomponent vaccines 有权
    多组分疫苗

    公开(公告)号：US08017133B2

    公开(公告)日：2011-09-13

    申请号：US12710790

    申请日：2010-02-23

    申请人： Joseph M. Patti ,  Timothy J. Foster ,  Magnus Hook

    发明人： Joseph M. Patti ,  Timothy J. Foster ,  Magnus Hook

    IPC分类号： A61K39/085

    CPC分类号： C07K16/1271 ,  A61K39/085

    摘要： Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus and other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as a capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.

    摘要翻译： 提供了有助于预防和治疗葡萄球菌感染的多组分疫苗，其包括某些所选择的细菌结合蛋白或其片段的组合，或对那些蛋白质或片段的抗体。 通过仔细选择蛋白质，片段或抗体，提供疫苗，其对广泛的葡萄球菌和其他细菌菌株和针对在对数生长曲线的不同阶段表达的蛋白质提供保护。 在本发明的一个实施方案中，提供了包括纤维蛋白原结合蛋白的纤维蛋白原结合结构域和诸如荚膜多糖的细菌组分的组合物，以及基于这些组分的主动和被动疫苗以及方法 使用这些组合物和疫苗治疗感染。

    Specific binding sites in collagen for integrins and use thereof
    7.
    发明申请
    Specific binding sites in collagen for integrins and use thereof 有权
    用于整联蛋白的胶原中的特异性结合位点及其用途

    公开(公告)号：US20090203627A1

    公开(公告)日：2009-08-13

    申请号：US12383746

    申请日：2009-03-26

    申请人： Magnus Hook ,  Xuejun Xu ,  Jiyeun Kim

    发明人： Magnus Hook ,  Xuejun Xu ,  Jiyeun Kim

    IPC分类号： A61K38/08 ,  C12N15/63 ,  C12N5/10 ,  G01N33/566 ,  C07K7/06 ,  C07K19/00 ,  C12N5/06

    CPC分类号： C07K14/00 ,  C07K7/06 ,  C07K14/78 ,  G01N33/566 ,  G01N33/6887 ,  G01N2333/70546 ,  G01N2333/78 ,  G01N2500/02

    摘要： The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.

    摘要翻译： 本发明鉴定了胶原结合整合蛋白I结构域中III型胶原中的高亲和力结合序列。 本文提供了用于表征序列的方法，包含该新型序列的肽以及肽在使细胞粘附中的用途。 本文还提供了鉴定特异性整联蛋白抑制剂，这些抑制剂的序列及其在抑制由于整合素 - 胶原相互作用可能引起的病理生理学病症中的用途的方法。

    Inhibitors of S. aureus SdrD protein attachment to cells and uses therefor
    8.
    发明申请
    Inhibitors of S. aureus SdrD protein attachment to cells and uses therefor 审中-公开
    金黄色葡萄球菌SdrD蛋白抑制剂附着于细胞及其用途

    公开(公告)号：US20090162379A1

    公开(公告)日：2009-06-25

    申请号：US12286586

    申请日：2008-10-01

    申请人： Magnus Hook ,  Elena M. Barbu

    发明人： Magnus Hook ,  Elena M. Barbu

    IPC分类号： A61K39/40 ,  G01N33/569 ,  G01N33/53 ,  C07K14/31 ,  A61K38/16 ,  C12N5/00 ,  C12N1/20 ,  C07K16/00 ,  A61P31/04

    CPC分类号： G01N33/5044 ,  A61K2039/505 ,  C07K16/1271 ,  G01N2333/31

    摘要： Provided herein is a method for identifying small molecule inhibitors of S. aureus SdrD protein attachment to a host cell receptor using a structural model of SdrD protein-receptor interaction. Also provided are the small molecule inhibitors so identified and synthetic small molecules effective to bind SdrD protein and/or the host cell receptor. In addition, antibodies directed against SdrD protein are provided. Further provided are methods of treating or preventing S. aureus associated lung infections and of inhibiting S. aureus adherence to a lung cell using the small molecules and antibodies described herein.

    摘要翻译： 本文提供了使用SdrD蛋白 - 受体相互作用的结构模型鉴定金黄色葡萄球菌SdrD蛋白附着于宿主细胞受体的小分子抑制剂的方法。 还提供了如此鉴定的小分子抑制剂和有效结合SdrD蛋白和/或宿主细胞受体的合成小分子。 此外，提供了针对SdrD蛋白的抗体。 还提供了使用本文所述的小分子和抗体治疗或预防金黄色葡萄球菌相关肺感染和抑制金黄色葡萄球菌粘附至肺细胞的方法。

    Method of preventing T cell-mediated responses by the use of the major histocompatibility complex class II analog protein (map protein) from Staphylococcus aureus
    9.
    发明申请
    Method of preventing T cell-mediated responses by the use of the major histocompatibility complex class II analog protein (map protein) from Staphylococcus aureus 审中-公开
    通过使用来自金黄色葡萄球菌的主要组织相容性复合物II类模拟蛋白（图蛋白）来预防T细胞介导的应答的方法

    公开(公告)号：US20070092533A1

    公开(公告)日：2007-04-26

    申请号：US11643714

    申请日：2006-12-22

    申请人： Eric Brown ,  Lawrence Lee ,  Magnus Hook

    发明人： Eric Brown ,  Lawrence Lee ,  Magnus Hook

    IPC分类号： A61K39/02

    CPC分类号： C07K14/31 ,  A61K38/00

    摘要： A method of immunomodulating the T cell response in Staphylococcal bacteria is provided wherein an effective amount of the Map protein from Staphylococcus aureus is administered to a host to prevent or suppress the T cell response. The present method may be utilized with either the Map protein or an effective subdomain or fragment thereof such as the Map19 protein. The present invention is advantageous in that suppression or prevention of the T cell response in a host can prevent or ameliorate a wide variety of the pathogenic conditions such as toxic shock syndrome and other diseases associated with the T cell-mediated response caused by staphylococcal infection, and is particularly useful in cases where patients have had chronic or recurrent infections from S. aureus or other staphylococcal bacteria.

    摘要翻译： 提供了一种在葡萄球菌中免疫调节T细胞应答的方法，其中向宿主施用有效量的来自金黄色葡萄球菌的Map蛋白以预防或抑制T细胞应答。 本方法可以与Map蛋白或有效亚结构域或其片段（如Map19蛋白）一起使用。 本发明的优点在于，抑制或预防宿主中的T细胞应答可以预防或改善各种各样的致病性病症如毒性休克综合征和与由葡萄球菌感染引起的T细胞介导的应答相关的其它疾病， 并且在患者具有来自金黄色葡萄球菌或其它葡萄球菌的慢性或反复感染的情况下特别有用。

    Compositions for inhibiting thrombin-induced coagulation and methods of use
    10.
    发明申请
    Compositions for inhibiting thrombin-induced coagulation and methods of use 审中-公开
    用于抑制凝血酶诱导的凝血的组合物及其使用方法

    公开(公告)号：US20060110380A1

    公开(公告)日：2006-05-25

    申请号：US11010406

    申请日：2004-12-14

    申请人： Stacey Davis ,  Magnus Hook

    发明人： Stacey Davis ,  Magnus Hook

    IPC分类号： A61K38/48

    CPC分类号： C07K14/31 ,  A61K38/164 ,  A61K38/482 ,  A61K2300/00

    摘要： A method of achieving safe and effective treatment or prevention of potentially harmful blood clots, or in inhibiting the coagulation of blood when so desired such as during a wide array of disease conditions including stroke, myocardial infarction, sickle-cell crisis and venous thrombosis, is provided by the administration of a fibrinogen-binding protein capable of binding at the N-terminal Bβ chain of fibrinogen, such as SdrG or Fbe, or their respective binding regions such as the A domain. In addition, compositions comprising effective amounts of the fibrinogen-binding proteins are also provided. The present anti-coagulation compositions have been shown to inhibit thrombin-induced fibrin clot formation by interfering with the release of fibrinopeptide B and the resulting anti-coagulation effects can be achieved without potential for causing or exacerbating unwanted side effects such as thrombocytopenia associated with prior art anticoagulants such as heparin.

    摘要翻译： 一种实现安全有效的治疗或预防潜在有害的血块，或在需要时抑制血液凝固的方法，例如在包括中风，心肌梗死，镰状细胞危象和静脉血栓形成在内的各种疾病状况下，是一种方法 通过施用能够在纤维蛋白原的N-末端Bbeta链（例如SdrG或Fbe）或其各自的结合区域如A结构域结合的纤维蛋白原结合蛋白提供。 此外，还提供了包含有效量的纤维蛋白原结合蛋白的组合物。 已经显示本发明的抗凝组合物通过干扰纤维蛋白肽B的释放来抑制凝血酶诱导的纤维蛋白凝块形成，并且可以实现所得的抗凝血作用，而不会引起或加剧不期望的副作用，例如与先前相关的血小板减少症 艺术抗凝剂如肝素。