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    Preparation of regenerative tissue scaffolds
    2.
    发明授权
    Preparation of regenerative tissue scaffolds 有权
    再生组织支架的制备

    公开(公告)号：US08784499B2

    公开(公告)日：2014-07-22

    申请号：US13070891

    申请日：2011-03-24

    申请人： Rick Owens ,  Wendell Sun ,  Mike Liu ,  Yong Mao

    发明人： Rick Owens ,  Wendell Sun ,  Mike Liu ,  Yong Mao

    IPC分类号： A61F2/28

    CPC分类号： A61F2/0063 ,  A61L27/3633 ,  A61L27/48

    摘要： Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.

    摘要翻译： 提供了用于治疗或修复组织或器官缺损或损伤的装置和方法。 该装置可以包括由无细胞组织基质和聚合物产生的组织支架，其具有稳定的三维形状并且引起有限的免疫学或炎症反应。

    Acellular tissue matrix preservation solution
    3.
    发明授权
    Acellular tissue matrix preservation solution 有权
    无细胞组织基质保存液

    公开(公告)号：US08735054B1

    公开(公告)日：2014-05-27

    申请号：US12348188

    申请日：2009-01-02

    申请人： Wendell Sun ,  Jerome Connor ,  Qing-Qing Qiu ,  Rick Owens ,  Mark Hayzlett

    发明人： Wendell Sun ,  Jerome Connor ,  Qing-Qing Qiu ,  Rick Owens ,  Mark Hayzlett

    IPC分类号： A01N1/00

    CPC分类号： A01N1/0294 ,  A01N1/00 ,  A01N1/0215

    摘要： The present disclosure provides a variety of methods and compositions (e.g., solutions) useful for making, sterilizing, and preserving tissues (e.g., acellular tissue matrices). The disclosure also features the acellular tissue matrices made by the methods, which matrices can be used for a variety of applications such as, but not limited to, treating an injury to, or repairing, a large number of tissues and/or organs (e.g., e.g., fascia, bones, and/or cartilage) in a mammal (e.g., a human).

    摘要翻译： 本公开提供了可用于制备，消毒和保存组织（例如，无细胞组织基质）的各种方法和组合物（例如，溶液）。 本公开还具有通过该方法制备的无细胞组织基质，该基质可用于多种应用，例如但不限于治疗大量组织和/或器官的损伤或修复（例如， 例如筋膜，骨骼和/或软骨）在哺乳动物（例如人）中。

    FUNCTIONALIZED TISSUE MATRICES
    4.
    发明申请
    FUNCTIONALIZED TISSUE MATRICES 有权
    功能组织矩阵

    公开(公告)号：US20130280223A1

    公开(公告)日：2013-10-24

    申请号：US13865629

    申请日：2013-04-18

    申请人： Rick Owens ,  Zhigang Liu

    发明人： Rick Owens ,  Zhigang Liu

    IPC分类号： A61K35/12 ,  A61K45/06 ,  A61K38/16 ,  A61K31/7088 ,  A61K38/50 ,  A61K38/48

    CPC分类号： A61K35/12 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/4886 ,  A61K38/50 ,  A61K45/06 ,  A61L27/362 ,  A61L27/3687

    摘要： Disclosed herein are tissue treatment products that have been bound to at least one chelating agent. Also disclosed are tissue treatment products that have been functionalized with at least one metal and/or at least one metal-binding protein. The tissue treatment products can have antimicrobial properties and/or factors that promote or enhance native cell migration, proliferation, and/or revascularization after implantation into a subject. Also disclosed are methods of making and using the tissue treatment products. The tissue treatment products can be implanted into a tissue in need of repair, regeneration, healing, treatment, and/or alteration and can promote or enhance native cell migration, proliferation, and/or revascularization.

    摘要翻译： 本文公开了已结合至少一种螯合剂的组织处理产品。 还公开了已经用至少一种金属和/或至少一种金属结合蛋白官能化的组织处理产品。 组织处理产品可具有在植入受试者之后促进或增强天然细胞迁移，增殖和/或血运重建的抗微生物特性和/或因素。 还公开了制备和使用组织处理产品的方法。 组织处理产品可以植入需要修复，再生，愈合，治疗和/或改变的组织中，并可以促进或增强天然细胞迁移，增殖和/或血运重建。

    Regenerative Tissue Scaffolds
    7.
    发明申请
    Regenerative Tissue Scaffolds 审中-公开
    再生组织支架

    公开(公告)号：US20120040013A1

    公开(公告)日：2012-02-16

    申请号：US13205899

    申请日：2011-08-09

    申请人： Rick Owens ,  Laura Elmo ,  Mike Liu ,  Yong Mao

    发明人： Rick Owens ,  Laura Elmo ,  Mike Liu ,  Yong Mao

    IPC分类号： A61K35/32 ,  A61P43/00 ,  A61K35/12

    摘要： Methods, mixtures, and kits related to treating tissue are provided. The methods, mixtures, and kits can include an acellular tissue matrix, a polymer, and a solvent and may be capable of producing tissue scaffolds. The tissue scaffolds may be able to form a stable, three-dimensional shape in situ and elicit a limited immunologic or inflammatory response.

    摘要翻译： 提供了与治疗组织相关的方法，混合物和试剂盒。 方法，混合物和试剂盒可以包括无细胞组织基质，聚合物和溶剂，并且可以能够产生组织支架。 组织支架可能能够原位形成稳定的三维形状并引起有限的免疫学或炎症反应。