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1.发明申请公开(公告)号：US20180087033A1
公开(公告)日：2018-03-29
申请号：US15705896
申请日：2017-09-15
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
CPC分类号： C12N5/0676 , A61K9/1652 , A61K9/5036 , A61K35/39 , A61K35/545 , A61K45/06 , C12N2500/05 , C12N2500/22 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/395 , C12N2501/40 , C12N2501/727 , C12N2501/91 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/45 , G01N33/507
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
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公开(公告)号：US10138466B2
公开(公告)日：2018-11-27
申请号：US15705896
申请日：2017-09-15
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
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公开(公告)号：US09828634B2
公开(公告)日：2017-11-28
申请号：US15004188
申请日：2016-01-22
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael , Guy Tagliavia
CPC分类号： C12Q1/6876 , A61K35/39 , A61K35/545 , C12N5/0676 , C12N5/0696 , C12N2500/25 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/22 , C12N2506/45 , C12N2510/00 , C12Q2600/158
摘要： Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for generating induced pluripotent cells (IPS) from human cells, differentiating the IPS into differentiated cells, and identifying differentiation specific markers.
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公开(公告)号：US10526576B2
公开(公告)日：2020-01-07
申请号：US16199681
申请日：2018-11-26
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
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5.发明授权Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells 有权将干细胞分化成包含β样细胞的细胞群的组合物和方法公开(公告)号：US09371516B2
公开(公告)日：2016-06-21
申请号：US14858465
申请日：2015-09-18
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
IPC分类号： A61K35/39 , C12N5/0735 , C12N5/071 , A61K9/16 , A61K45/06
CPC分类号： C12N5/0676 , A61K9/1652 , A61K9/5036 , A61K35/39 , A61K35/545 , A61K45/06 , C12N2500/05 , C12N2500/22 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/395 , C12N2501/40 , C12N2501/727 , C12N2501/91 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/45 , G01N33/507
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
摘要翻译： 提供了用于培养多能干细胞以产生包含β样细胞（例如胰腺谱系，葡萄糖反应性和/或产生胰岛素）的细胞群的方法，试剂盒，组合物和系统。 特别地，提供导致从人多能干细胞的起始培养产生β样细胞的培养条件。
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6.发明申请公开(公告)号：US20190093083A1
公开(公告)日：2019-03-28
申请号：US16199681
申请日：2018-11-26
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
CPC分类号： C12N5/0676 , A61K9/1652 , A61K9/5036 , A61K35/39 , A61K35/545 , A61K45/06 , C12N2500/05 , C12N2500/22 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/395 , C12N2501/40 , C12N2501/727 , C12N2501/91 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/45 , G01N33/507 , H05K999/99
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
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公开(公告)号：US09765302B2
公开(公告)日：2017-09-19
申请号：US15187345
申请日：2016-06-20
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
CPC分类号： C12N5/0676 , A61K9/1652 , A61K9/5036 , A61K35/39 , A61K35/545 , A61K45/06 , C12N2500/05 , C12N2500/22 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/395 , C12N2501/40 , C12N2501/727 , C12N2501/91 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/45 , G01N33/507
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
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公开(公告)号：US20160298088A1
公开(公告)日：2016-10-13
申请号：US15187345
申请日：2016-06-20
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
CPC分类号： C12N5/0676 , A61K9/1652 , A61K9/5036 , A61K35/39 , A61K35/545 , A61K45/06 , C12N2500/05 , C12N2500/22 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/395 , C12N2501/40 , C12N2501/727 , C12N2501/91 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/45 , G01N33/507
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
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9.发明申请COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS 有权将干细胞分化成包含BETA细胞的细胞群体的组合物和方法公开(公告)号：US20160083693A1
公开(公告)日：2016-03-24
申请号：US14858465
申请日：2015-09-18
发明人： Xiaofang Xu , Jon Odorico , Erik Forsberg , Amber A. Mael
CPC分类号： C12N5/0676 , A61K9/1652 , A61K9/5036 , A61K35/39 , A61K35/545 , A61K45/06 , C12N2500/05 , C12N2500/22 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/395 , C12N2501/40 , C12N2501/727 , C12N2501/91 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2506/45 , G01N33/507
摘要： Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
摘要翻译： 提供了用于培养多能干细胞以产生包含β样细胞（例如胰腺谱系，葡萄糖反应性和/或产生胰岛素）的细胞群的方法，试剂盒，组合物和系统。 特别地，提供导致从人多能干细胞的起始培养产生β样细胞的培养条件。
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