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公开(公告)号：US20090074778A1
公开(公告)日：2009-03-19
申请号：US11962282
申请日：2007-12-21
申请人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
发明人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
IPC分类号： A61K39/395 , C07H21/00 , C12N15/63 , C12N5/00 , A61K38/16 , A61P5/00 , C12Q1/68 , C12P21/00 , C07K14/575 , C07K16/00
CPC分类号： C07H21/04 , C07K14/475 , Y10S530/866
摘要： The present invention relates to a novel connective tissue growth factor-3 protein which is a member of the growth factor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human connective tissue growth factor-3 protein. Connective tissue growth factor-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods for detecting and treating connective tissue related disorders.
摘要翻译： 本发明涉及作为生长因子超家族成员的新型结缔组织生长因子-3蛋白质。 特别地，提供编码人结缔组织生长因子-3蛋白的分离的核酸分子。 还提供结缔组织生长因子-3多肽，载体，宿主细胞和用于制备它们的重组方法。 还提供了用于检测和治疗结缔组织相关疾病的诊断和治疗方法。
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公开(公告)号：US20100196383A1
公开(公告)日：2010-08-05
申请号：US12761083
申请日：2010-04-15
申请人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
发明人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
IPC分类号： A61K38/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C07K14/475 , C07K16/22 , A61K39/395 , C12Q1/68 , A61P43/00
CPC分类号： C07H21/04 , C07K14/475 , Y10S530/866
摘要： The present invention relates to a novel connective tissue growth factor-3 protein which is a member of the growth factor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human connective tissue growth factor-3 protein. Connective tissue growth factor-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods for detecting and treating connective tissue related disorders.
摘要翻译： 本发明涉及作为生长因子超家族成员的新型结缔组织生长因子-3蛋白质。 特别地，提供编码人结缔组织生长因子-3蛋白的分离的核酸分子。 还提供结缔组织生长因子-3多肽，载体，宿主细胞和用于制备它们的重组方法。 还提供了用于检测和治疗结缔组织相关疾病的诊断和治疗方法。
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公开(公告)号：US20110256145A1
公开(公告)日：2011-10-20
申请号：US13172664
申请日：2011-06-29
申请人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
发明人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , C12P21/06 , A61P19/04 , C07K7/08 , C07K16/22 , A61K38/18 , C12Q1/68 , C07H21/04 , C07K14/475
CPC分类号： C07H21/04 , C07K14/475 , Y10S530/866
摘要： The present invention relates to a novel connective tissue growth factor-3 protein which is a member of the growth factor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human connective tissue growth factor-3 protein. Connective tissue growth factor-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods for detecting and treating connective tissue related disorders.
摘要翻译： 本发明涉及作为生长因子超家族成员的新型结缔组织生长因子-3蛋白质。 特别地，提供编码人结缔组织生长因子-3蛋白的分离的核酸分子。 还提供结缔组织生长因子-3多肽，载体，宿主细胞和用于制备它们的重组方法。 还提供了用于检测和治疗结缔组织相关疾病的诊断和治疗方法。
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公开(公告)号：US07994284B2
公开(公告)日：2011-08-09
申请号：US12761083
申请日：2010-04-15
申请人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
发明人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
IPC分类号： C07K14/475 , C07K19/00
CPC分类号： C07H21/04 , C07K14/475 , Y10S530/866
摘要： The present invention relates to a novel connective tissue growth factor-3 protein which is a member of the growth factor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human connective tissue growth factor-3 protein. Connective tissue growth factor-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods for detecting and treating connective tissue related disorders.
摘要翻译： 本发明涉及作为生长因子超家族成员的新型结缔组织生长因子-3蛋白质。 特别地，提供编码人结缔组织生长因子-3蛋白的分离的核酸分子。 还提供结缔组织生长因子-3多肽，载体，宿主细胞和用于制备它们的重组方法。 还提供了用于检测和治疗结缔组织相关疾病的诊断和治疗方法。
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公开(公告)号：US07737257B2
公开(公告)日：2010-06-15
申请号：US11962282
申请日：2007-12-21
申请人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
发明人： Reinhard Ebner , Arvind Chopra , Steven M. Ruben
CPC分类号： C07H21/04 , C07K14/475 , Y10S530/866
摘要： The present invention relates to a novel connective tissue growth factor-3 protein which is a member of the growth factor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human connective tissue growth factor-3 protein. Connective tissue growth factor-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods for detecting and treating connective tissue related disorders.
摘要翻译： 本发明涉及作为生长因子超家族成员的新型结缔组织生长因子-3蛋白质。 特别地，提供编码人结缔组织生长因子-3蛋白的分离的核酸分子。 还提供结缔组织生长因子-3多肽，载体，宿主细胞和用于制备它们的重组方法。 还提供了用于检测和治疗结缔组织相关疾病的诊断和治疗方法。
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公开(公告)号：US20090247482A1
公开(公告)日：2009-10-01
申请号：US12275899
申请日：2008-11-21
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20090226456A1
公开(公告)日：2009-09-10
申请号：US12463301
申请日：2009-05-08
申请人： Reiner L. Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
发明人： Reiner L. Gentz , Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben , Jian Ni , Ping Feng
IPC分类号： A61K39/395 , C12N15/12 , C07K14/705 , C07K16/28 , C12N15/85 , C12N5/10 , C12P21/02 , A61K31/7088 , C12N5/16 , G01N33/566
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20080146505A1
公开(公告)日：2008-06-19
申请号：US11832009
申请日：2007-08-01
申请人： Steven M. Ruben , Reinhard Ebner , Craig A. Rosen , Gregory A. Endress , Daniel R. Soppet , Jian Ni , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Henrik S. Olsen , Kimberly A. Florence
发明人： Steven M. Ruben , Reinhard Ebner , Craig A. Rosen , Gregory A. Endress , Daniel R. Soppet , Jian Ni , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Henrik S. Olsen , Kimberly A. Florence
IPC分类号： A61K38/16 , C07H21/00 , C12N15/63 , C12N5/00 , A61K31/7052 , C07K14/00 , C12P21/00 , G01N33/68 , C07K16/00 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US07247442B1
公开(公告)日：2007-07-24
申请号：US10849979
申请日：2004-05-21
申请人： Steven M. Ruben , Kimberly A. Florence , Jian Ni , Craig A. Rosen , Kenneth C. Carter , Paul A. Moore , Henrik S. Olsen , Yanggu Shi , Paul E. Young , Ying-Fei Wei , Laurie A. Brewer , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , Charles E. Birse
发明人： Steven M. Ruben , Kimberly A. Florence , Jian Ni , Craig A. Rosen , Kenneth C. Carter , Paul A. Moore , Henrik S. Olsen , Yanggu Shi , Paul E. Young , Ying-Fei Wei , Laurie A. Brewer , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , Charles E. Birse
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US06815534B2
公开(公告)日：2004-11-09
申请号：US10057951
申请日：2002-01-29
申请人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
发明人： Paul A. Moore , Steven M. Ruben , Reinhard Ebner
IPC分类号： C07K1640
CPC分类号： C12N9/6456 , A61K38/00 , C07K2319/00 , C12N9/6421 , C12N2799/026 , Y10S530/827 , Y10S530/828
摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。
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